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| 1 | Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment显示文摘Background:Early neurologic deterioration(END)may occur in patients with anterior circulation ischemic stroke(ACIS)after receiving endovascular treatment(EVT).Hemodynamic insufficiency,re-occlusion,and post-re-canalization hyper-perfusion are likely to play a critical role in END.We hypothesized that hemodynamic changes can predict END in patients with ACIS postsuccessful EVT using trans-cranial Doppler(TCD).Methods:We utilized a prospectively maintained database of ACIS patients treated with EVT between September 2016 and June 2018 in the Xuanwu Hospital,Capital Medical University.TCD parameters including peak systolic velocity(PSV),bilateral mean flow velocity(MFV),and pulse index(PI)were determined via the middle cerebral arteries within 72 h post-EVT.A logistic regression model was applied to detect independent predictors for END.Results:Totally,112 EVT patients were included in this study and 80/112 patients experienced successful re-canalization with<50%residual stenosis,while 17/80(21.3%)patients suffered END,for which vasogenic cerebral edema(11/17)was considered as a leading role and followed by symptomatic intra-cranial hemorrhage(4/17)and ischemia progression(2/17).For the 80 patients,the PSV(median:127 cm/s vs.116 cm/s,P=0.039),the ratio of ipsilateral-MFV/contra-lateral-MFV(iMFV/cMFV)(median:1.29 vs.1.02,P=0.036)and iMFV/mean blood pressure(MBP)(median:0.97 vs.0.79,P=0.008)in END patients were higher than those of non-END.Using the receiver-operating characteristic curve to obtain cut-off values for PSV,PI,iMFV/cMFV,and iMFV/MBP for END,we found that PI≥0.85(odds ratio:11.03,95%confidence interval:1.92–63.46,P=0.007)and iMFV/MBP≥0.84(odds ratio:9.20,95%confidence interval:2.07–40.84,P=0.004)were independent predictors of END in a multivariate logistic regression model,with a sensitivity of 82.4%and 76.5%and a specificity of 42.9%and 66.7%,respectively,and had the positive predictive values of 29.0%and 38.2%,and negative predictive values of 90.0%and 91.3%,with an area under the receiveroperating characteristic curve of 0.57 and 0.71,respectively.Conclusion:TCD examination of EVT patients may be used as a real-time tool to detect END predictors,such as the higher PI and iMFV/MBP,allowing for better post-thrombectomy management in ACIS patients. | Yan-Bo He Ying-Ying Su Gary BRajah Ying-Bo Zhang Un-Lin Fan Gang Liu Hong-Bo Chen | 2020 | Chinese Medical Journal2020，，14： | 6 |
| 2 | Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection显示文摘Dear Editor,The 2015–2016 outbreak of Zika virus(ZIKV)fever,first reported in Brazil during early 2015(Zanluca et al.,2015),has infected millions of people and is a global public health concern.ZIKV infections are associated with fetal microcephaly,as well as neurological | gary wong shihua he vinayakumar siragam yuhai bi majambu mbikay michel chretien xiangguo qiu | 2017 | Virologica Sinica2017，32，6： | 5 |
| 3 | Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds,2014–2015显示文摘A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015.Based on the genetic and phylogenetic analyses,the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA,a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin.The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain(A/Alberta/01/2014).Further analysis showed that similar viruses have been circulating in wild birds in China,Russia,Dubai(Western Asia),Bulgaria and Romania(Europe),as well as domestic poultry in some regions of Africa.The affected areas include the Central Asian,East Asian-Australasian,West Asian-East African,and Black Sea/Mediterranean flyways.These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds,thus posing a serious threat to wild birds and potentially humans. | Yuhai Bi Jianjun Chen Zhenjie Zhang Mingxin Li Tianlong Cai Kirill Sharshov Ivan Susloparov Alexander Shestopalov Gary Wong Yubang He Zhi Xing Jianqing Sun Di Liu Yingxia Liu Lei Liu Wenjun Liu Fumin Lei Weifeng Shi George F. Gao | 2016 | Virologica Sinica2016，31，4： | 5 |
| 4 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 5 | Low power 3.1–10.6 GHz IR-UWB transmitter for Gbps wireless communications显示文摘This paper reviews and discusses the design of a low-power single-full-band (3.1-10.6 GHz) non- carrier impulse-radio ultra wideband (UWB) transmitter featuring 5th-order Gaussian derivative pulse shaping, integrated BPSK modulation, and 2.5 kV whole-chip ESD (electrostatic discharge) protection. The UWB transmitter design has been implemented in a commercial 0.18 μm CMOS technology with a very small die size of 0.25 mm2. The fabricated chips have demonstrated full functionality, extremely low power consumption of 0.14 pJ/p-mV, and an ultra short pulse width of 394 ps. This ESD-protected UWB transmitter has the potential to support wireless streaming to gigabit per second (Gbps). | WANG Xin LIN Lin TANG He ZHAO Hui FANG Qiang LIU Jian FAN SiQiang WANG Albert ZHAO Bin YANG LiWu ZHANG Gary | 2011 | Science China(Information Sciences)2011，54，5： | 2 |
| 6 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 7 | Duration of poliovirus excretion and its implications for acuteflaccid paralysis surveillance:areview of the literature 显示文摘 | Alexander JP Gary HE Pallansch MA | 1997 | J Infect Dis1997，175，1： | 1 |
| 8 | Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study显示文摘 | Bryan T. Mott Ran He Xiaochun Chen Jennifer M. Fox Curt I. Civin Ravit Arav-Boger Gary H. Posner | 2013 | Bioorganic & Medicinal Chemistry2013，，： | 1 |
| 9 | Poliovirus detection in wastewater and stools following an immunization campaign in Havana,Cuba显示文摘 | Mas LP Gary HE Jr Perez LS | 2003 | Int J Epidemiol2003，32，5： | 1 |
| 10 | Duration of poliovirus excretion and its implications for acute flaccid paralysis surveil- lance: a review of the literature 显示文摘 | Alexander JP Gary HE Pallansch MA | 1997 | J Infect Dis1997，175，1： | 1 |
| 11 | Initial CT findings in 753 patients with severe head injury: a report from the NIH Traumatic Coma Data Bank显示文摘 | Eisenberg HM Gary HE Aldrich EF | 1990 | Neurosurgery1990，73，： | 1 |
| 12 | A Novel Thermal Model for the Lattice Boltzmann Method in Incompressible Limit显示文摘 | Xiaoyi He Shiyi Chen Gary D. Doolen | 1998 | Journal of Computational Physics1998，，1： | 1 |
| 13 | MicroRNA-181b regulates NF-[kappa]B-mediated vascular inflammation显示文摘 | Sun Xinghui Icli Basak Wara Akm Khyrul Belkin Nathan He Shaolin Kobzik Lester Hunninghake Gary M Vera Miguel Pinilla Blackwell Timothy S Baron Rebecca M Feinberg Mark W | 2012 | EN2012，，： | 1 |
| 14 | Application of ICA in removing artefacts from the ECG显示文摘 | HE Taigang GARI C LIONEL T | 2004 | Neural Processing Letters2004，10，1： | 1 |
| 15 | Poliovirus detection in wastewater and stools following an immunization campaign in Havana, Cuba 显示文摘 | Mas Lp Gary HE Jr Perez LS | 2003 | int J Epidemiol2003，32，5： | 1 |
| 16 | Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin显示文摘 | TaiHao Quan TianYuan He Yuan Shao Lin Lin Sewon Kang John J. Voorhees Gary J. Fisher | 2006 | The American Journal of Pathology2006，，2： | 1 |
| 17 | Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults显示文摘 | Doweli SF Anderson LJ Gary HE | 1996 | J Infect Dis1996，174，： | 1 |
| 18 | Can post-eradication laboratory containment of wild polioviruses be achieved显示文摘 | Dowdle WR Gary HE Sanders R | 2001 | Bull World Health Organ2001，80，4： | 1 |
| 19 | Characterization of a trypsin-dependent avian influenza H5N1-pseudotyped HIV vector system for high throughput screening of inhibitory molecules显示文摘 | Zhujun Ao Ami Patel Kaylie Tran Xinying He Keith Fowke Kevin Coombs Darwyn Kobasa Gary Kobinger Xiaojian Yao | 2008 | Antiviral Research2008，，1： | 1 |
| 20 | Poliovirus detection inwastewater and stools following an immunization campaign in Ha-vana, Cuba显示文摘 | Mas Lp Gary HE Jr Perez LS | 2003 | Int J Epidemiol2003，32，5： | 1 |
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