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| 1 | Rectal cancer: An evidence-based update for primary care providers显示文摘Rectal adenocarcinoma is an important cause of cancer-related deaths worldwide, and key anatomic differences between the rectum and the colon have significant implications for management of rectal cancer. Many advances have been made in the diagnosis and management of rectal cancer. These include clinical staging with imaging studies such as endorectal ultrasound and pelvic magnetic resonance imaging, operative approaches such as transanal endoscopic microsurgery and laparoscopic and robotic assisted proctectomy, as well as refined neoadjuvant and adjuvant therapies. For stage Ⅱ and Ⅲ rectal cancers, combined chemoradiotherapy offers the lowest rates of local and distant relapse, and is delivered neoadjuvantly to improve tolerability and optimize surgical outcomes, particularly when sphincter-sparing surgery is an endpoint. The goal in rectal cancer treatment is to optimize diseasefree and overall survival while minimizing the risk of local recurrence and toxicity from both radiation and systemic therapy. Optimal patient outcomes depend on multidisciplinary involvement for tailored therapy. The successful management of rectal cancer requires a multidisciplinary approach, with the involvement of enterostomal nurses, gastroenterologists, medical and radiation oncologists, radiologists, pathologists and surgeons. The identification of patients who are candidates for combined modality treatment is particularly useful to optimize outcomes. This article provides an overview of the diagnosis, staging and multimodal therapy of patients with rectal cancer for primary care providers. | Wolfgang B Gaertner Mary R Kwaan Robert D Madoff Genevieve B Melton | 2015 | World Journal of Gastroenterology2015，21，25： | 13 |
| 2 | Multidisciplinary and evidence-based management of fistulizing perianal Crohn's disease显示文摘Perianal symptoms are common in patients with Crohn's disease and cause considerable morbidity. The etiology of these symptoms include skin tags, ulcers, fissures, abscesses, fistulas or stenoses. Fistula is the most common perianal manifestation. Multiple treatment options exist although very few are evidence-based. The phases of treatment include: drainage of infection, assessment of Crohn's disease status and fistula tracts, medical therapy, and selective operative management. The impact of biological therapy on perianal Crohn's disease is uncertain given that outcomes are conflicting. Operative treatment to eradicate the fistula tract can be attempted once infection has resolved and Crohn's disease activity is controlled. The operative approach should be tailored according to the anatomy of the fistula tract. Definitive treatment is challenging with medical and operative treatment rarely leading to true healing with frequent complications and recurrence. Treatment success must be weighed against the risk of complications, specially anal sphincter injury. A full understanding of the etiology and all potential therapeutic options is critical for success. Multidisciplinary management of fistulizing perianal Crohn's disease is crucial toimprove outcomes. | Ricardo Sordo-Mejia Wolfgang B Gaertner | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 5 |
| 3 | Load-related bonemodelling at the interface of orthodontic micro-implants显示文摘 | Büchter A Wiechmann D Gaertner C | 2006 | ClinOral Implants Res2006，17，6： | 1 |
| 4 | De novo desmin?mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy显示文摘 | Klauke B Kossmann S Gaertner A | 2010 | Hum Mol Genet2010，19，23： | 1 |
| 5 | Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case显示文摘 | Krus-Lsler B Gaertner C BUrger H | 2006 | Oral Surg Oral Med Oral Pathol Oral Radio Endod2006，102，2： | 1 |
| 6 | Block of the brachial plexus branches by the humeral route: A prospective study of 503 ambulatory patients-proposal of a nerve blocing sequence 显示文摘 | Kern O Mahoudeau G Freys G Golfetto T Calon B | 1999 | Acta Anaesthesiol Scand1999，43，： | 1 |
| 7 | Intergroup Threat and Outgroup Attitudes:A Meta-Analytic Review显示文摘 | RIEK B M MANIA E W GAERTNER S L | 2006 | Personality and Social Psychology Review2006，10，4： | 1 |
| 8 | Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case显示文摘 | Birgit Kruse-L?sler Christoph Gaertner Horst Bürger László Seper Ulrich Joos Johannes Kleinheinz | 2006 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2006，，2： | 1 |
| 9 | Central giant cell granuloma of the jaws:a clinical,radiologic,and histopathologic study of 26 cases显示文摘 | Kruse-Losler B Diallo R Gaertner C | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，101，3： | 1 |
| 10 | Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis显示文摘 | Gaertner S de Graaf KL Greve B | 2004 | Neurology2004，63，12： | 1 |
| 11 | De novo desmin- mutation Nll6S is associated with arrhythmogenic right ventricular cardiomyopathy显示文摘 | Klauke B Kossmann S Gaertner A | 2010 | Hum Mol Genet2010，19，23： | 1 |
| 12 | Melanotic neuroectodermal tumor of infancy: Systematic review of the literature and presentation of a case显示文摘 | Kruse- Lsler B Gaertner C Bttrger H | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，2： | 1 |
| 13 | Kidney function and white matter disease in young stroke patients : analysis of the stroke in young fabry patients study population 显示文摘 | Steinicke R Gaertner B Grittner U | 2012 | Stroke2012，43，9： | 1 |
| 14 | Real-time DNA sequencing from single polymerase molecules显示文摘 | Eid J Fehr A Gray J Luong K Lyle J Otto G Peluso P Rank D Baybayan P Bettman B Bibillo A Bjornson K Chaudhuri B Christians F Cicero R Clark S Dalal R Dewinter A Dixon J Foquet M Gaertner A Hardenbol P Heiner C Hester K Holden D Kearns G Kong X Kuse R Lacr | | 0，，5910： | 1 |
| 15 | Reducing intergroup conflict:From superordinate goals to decategorization,recategorization,and mutual differentiation 显示文摘 | D0vidio J F Banker B S Houlette M Johnson K M McGlynn E A | 2000 | Group Dynamics2000，4，： | 1 |
| 16 | Targeting of tumor blood vessels: a phage-displayed tumor-homing peptide specifically binds to matrix metalloproteinase-2-processed collagen Ⅳ and blocks angiogenesis in vivo显示文摘 | Mueller J Gaertner FC Blechert B | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 17 | Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis显示文摘 | Gaertner S de Graaf KL Greve B | 2004 | Neurology2004，63，12： | 1 |
| 18 | Antibodies against glyco- sylated native MOG are elevated in patients with multiple sclerosis 显示文摘 | Gaertner S de Graaf K L Greve B et aI | 2004 | Neurology2004，63，12： | 1 |
| 19 | Extending the Benefits of Re- categorization: Evaluations, Self- Disclosure, and Helping 显示文摘 | Dovidio J F Gaertner S L Validzic A Matoka A Johnson B Frazier S | 1997 | Journal of Experimental Social Psychol- ogy1997，，33： | 1 |
| 20 | Meal replacement reduces insulin requirement, HbAlc and weight long-term in type 2 diabetes patients with > 100 U insulin per day显示文摘 | Kempf K Schloot NC Gaertner B | 2014 | J Hum Nutr Diet2014，27，2： | 1 |
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