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| 1 | Techniques for staining the agent of digestive gland disease of fiat oysters,Ostrea edulis L显示文摘 | Gutiié rrez M | 1977 | Investigacion Pesquera(Barcelona)1977，41，： | 1 |
| 2 | Stability of total selenium and selenium species in lyophilised oysters and in their enzy- matic extracts 显示文摘 | MORENO P QUIJANO M A GUTII~RREZ A M | 2002 | Analytical Bioanalytical Chemistry2002，374，3： | 1 |
| 3 | Nuevos registros de macrohongos (Basidiomycota) para Colombia procedentes de un bosque seco tropical显示文摘 | PALACIO M GUTII~RREZ Y FRANCO-MOLANO AIE | 2014 | Actual Biol2014，37，102： | 1 |
| 4 | Bioac- tive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile显示文摘 | GUTII~RREZ M THEODULOZ C RODR~QUEZ J | 2005 | J Agric Food Chem2005，53，20： | 1 |
| 5 | Nano - emulsions : New applications and optimization of their preparation 显示文摘 | GUTII~RREZ J M GONZ~LEZ C MAESTRO A | 2008 | Current Opinion in Colloid & Interface Science2008，13，： | 1 |
| 6 | Nano-emulsions: New Applications and Optimization of Their Preparation 显示文摘 | GUTII~RREZ J M GONZ~LEZ C MAESTRO A et ol | 2008 | Current Opinion in Colloid & Interface Science2008，13，4： | 1 |
| 7 | Effect of repeated administration of lipopo- lysaccharide on inflammatory and stress markers in sa- liva of growing pigs 显示文摘 | ESCRIBANO D CAMPOS P H R F GUTII~RREZ A M | | The Veterinary Journal0，200，3： | 1 |
| 8 | Interaction of tocopherols and phenolic compounds with membrane lipid components: evaluation of theirantioxidant activity in a liposomal model system 显示文摘 | GUTII~RREZ M E GARCIA A F AFRICA De MADARIAGA M | 2003 | Life Sci2003，72，21： | 1 |
| 9 | Apratoxin D,a potent cytotoxic cyclodepsipeptide from Papua New Guinea collections of the ma- rine cyanobacteria Lyngbya majuscula and Lyngbya sordida 显示文摘 | GUTII~RREZ M SUYAMA T L ENGENE N | 2008 | Nat Prod2008，71，6： | 1 |
| 10 | Development of the digestive tract, trypsin activity andgene expression in eggs and larvae of the bullseyepuffer fish Sphoeroides annulatus 显示文摘 | Garcia-Gasca A Galaviz M A Gutie rrez J N | 2006 | Aquaculture2006，251，214： | 1 |
| 11 | Giannini prosthesis for flatfoot显示文摘 | Gutiérrez PR Herrera M | | 0，，： | 1 |
| 12 | Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis显示文摘AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis.METHODS:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats.The mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis induction.The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were evaluated.Peritoneal and alveolar macrophages were obtained and the expression of tumor necrosis factor α was determined.Myeloperoxidase activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory process.Finally,the effect of plasma on cultured mast cells or macrophages was evaluated in vitro.RESULTS:The mast cell stabilizer signif icantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal macrophages.Mast cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the lung.Plasma from rats with pancreatitis could activate alveolar macrophages but did not induce degranulation of mast cells in vitro.CONCLUSION:Pancreatic mast cells play an important role in triggering the local and systemic inflammatory response in the early stages of acute pancreatitis.In contrast,lung mast cells are not directly involved in the inflammatory response related to pancreatic damage. | Inmaculada Lopez-Font Sabrina Gea-Sorlí Enrique de-Madaria Luis M Gutiérrez Miguel Pérez-Mateo Daniel Closa | 2010 | World Journal of Gastroenterology2010，16，27： | 10 |
| 13 | Gut epithelial barrier dysfunction in humanimmunodeficiency virus-hepatitis C virus coinfectedpatients:Influence on innate and acquired immunity显示文摘Even in cases where viral replication has been controlled by antiretroviral therapy for long periods of time, human immunodeficiency virus(HIV)-infected patients have several non-acquired immunodeficiency syndrome(AIDS) related co-morbidities, including liver disease, cardiovascular disease and neurocognitive decline, which have a clear impact on survival. It has been considered that persistent innate and acquired immune activation contributes to the pathogenesis of these non-AIDS related diseases. Immune activation has been related with several conditions, remarkably with the bacterial translocation related with the intestinal barrier damage by the HIV or by hepatitis C virus(HCV)-related liver cirrhosis. Consequently, increased morbidity and mortality must be expected in HIV-HCV coinfected patients. Disrupted gut barrier lead to an increased passage of microbial products and to an activation of the mucosal immune system and secretion of inflammatory mediators, which in turn might increase barrier dysfunction. In the present review, the intestinal barrier structure, measures of intestinal barrier dysfunction and the modifications of them in HIV monoinfection and in HIV-HCV coinfection will be considered. Both pathogenesis and the consequences for the progression of liver disease secondary to gut microbial fragment leakage and immune activation will be assessed. | Mercedes Márquez Clotilde Fernández Gutiérrez delÁlamo JoséAntonio Girón-González | 2016 | World Journal of Gastroenterology2016，22，4： | 7 |
| 14 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 15 | Alcohol liver disease: A review of current therapeutic approaches to achieve long-term abstinence显示文摘Harmful alcohol drinking may lead to significant damage on any organ or system of the body.Alcoholic liver disease(ALD) is the most prevalent cause of advanced liver disease in Europe.In ALD,only alcohol abstinence was associated with a better long-term survival.Therefore,current effective therapeutic strategy should be oriented towards achieving alcohol abstinence or a significant reduction in alcohol consumption.Screening all primary care patients to detect those cases with alcohol abuse has been proposed as population-wide preventive intervention in primary care.It has been suggested that in patients with mild alcohol use disorder the best approach is brief intervention in the primary care setting with the ultimate goal being abstinence,whereas patients with moderate-to-severe alcohol use disorder must be referred to specialized care where detoxification and medical treatment of alcohol dependence must be undertaken. | María Luisa Gutiérrez García Sara Blasco-Algora Conrado M Fernández-Rodríguez | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 16 | Surface textures of heavy-mineral grainst a new contribution to provenance studies显示文摘 | Cardona J P M Gutie'rrez Mas J M Bello'n A S | 2005 | Sedimentary Geology2005，174，： | 1 |
| 17 | A comparative study of sensor array and GC-MS:application to Madrid wines characterization显示文摘 | Santos JP Arroyo T Aleixandre M Lozano J Sayago I García M Femández MJ Arésa L Gutiérrez J Cabellos JM Gil M Horrillo MC | | 0，，02： | 1 |
| 18 | Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper(Terciopelo) snake venom, on mouse capillary blood vessels显示文摘 | Moreira L Borkow G Ovadia M Gutiérrez JM | 1994 | Toxicon1994，32，8： | 1 |
| 19 | I,mprovingout comes of elderly patients with community acquired pneumonia显示文摘 | Guti é rrez F Masi á M | 2008 | DrugsAging2008，25，7： | 1 |
| 20 | Interfacial properties and foam stability effect of novel gemini-type surfactants in aqueous solutions显示文摘 | Durga P Acharya José M Gutiérrez | 2005 | Journal of Colloid and Interface Science2005，291，： | 1 |
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