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| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | Carbon/carbon supercapacitors显示文摘Supercapacitors, or electrochemical capacitors, are a power storage system applied for harvesting energy and delivering pulses during short periods of time. The commercially available technology is based on charging an electrical double-layer (EDL), and using high surface area carbon electrodes in an organic electrolyte. This review first presents the state-of-the-art on EDL capacitors, with the objective to better understand their operating principles and to improve their performance. In particular, it is shown that capacitance might be enhanced for carbons having subnanometric pores where ions of the electrolyte are distorted and partly desolvated. Then, strategies for using environment friendly aqueous electrolytes are presented. In this case, the capacitance can be enhanced through pseudo-faradaic contributions involving i) surface functional groups on carbons, ii) hydrogen electrosorption, and iii) redox reactions at the electrode/electrolyte interface. The most promising system is based on the use of aqueous alkali sulfate as electrolyte allowing voltages as high as 2 V to be reached, due to the high overpotential for di-hydrogen evolution at the negative electrode. | Elzbieta Frackowiak Qamar Abbas Franois Bguin | 2013 | Journal of Energy Chemistry2013，22，2： | 10 |
| 3 | Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy显示文摘遇见 c 的 proto-oncogenes 和 RON 的产品属于受体酷氨酸 kinases 的一个亚科显著地作出贡献到 tumorigenic 前进。在主要肿瘤,改变了调整被房间移植和矩阵侵略描绘的侵略生长的 c-MET/RON 表达式 transduces 信号。这些病原的特征为在癌症治疗指向 c-MET/RON 提供基础。在最后十年,各种各样的途径被调查了压制 c-MET/RON-transduced oncogenesis。在开发的治疗学之中, monoclonal 抗体(mAbs ) 和小分子的禁止者(SMI ) 作为有希望的候选人出现了。这些治疗学的候选人的机制是为幸存的 c-MET/RON 信号上的肿瘤相关性的混乱。对 hepatocyte 生长因素(AMG102 ) 特定、遇见 c 的 mAbs (MetMAb ) 是人性化并且能堵住遇见 c 的发信号,在异种皮移植在肿瘤生长的 vitro 和抑制导致肿瘤房间增长的抑制当模特儿。mAb AMG102 抵销 hepatocyte 生长因素并且在 vivo 提高各种各样的 chemotherapeutics 的 cytotoxicity 到肿瘤。AMG102 当前在为有先进稳固的肿瘤的病人的阶段 II 临床的试用。IMC-41A40 和 Zt/f2 是 RON 特定的 mAbs 那下面调整 RON 表情并且禁止导致 ligand 的 phosphorylation。两 mAbs 在老鼠禁止肿瘤生长由冒号和胰腺的癌症细胞调停了。对特定的 SMI 遇见 c (ARQ107 和 PF-02341066 ) 在临床的试用的各种各样的阶段。治疗学的功效也与象化合物那样的双禁止者被观察了我,它对 c-MET/RON 特定。然而,一个潜在的问题是到这些禁止者的获得的抵抗的出现。清楚地, c-MET/RON 治疗学的开发为以后与癌症作斗争提供机会和挑战。 | Ming-Hai WANG Snehal S PADHYE Sunny GUIN Qi MA Yong-qing ZHOU | 2010 | Acta Pharmacologica Sinica2010，31，9： | 10 |
| 4 | Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model显示文摘OBJECTIVE: To investigate the antidepressant-likeeffect of active fraction of Polyrhachis vicina Roger(AFPR) in a rat depression model, and to elucidate the underlying mechanism.METHODS: AFPR was extracted with ethanol followed by petroleum ether. Its antidepressant-like effect was investigated in mice by tail suspension test(TST), forced swimming test(FST) and open field test(OPT). A repeated dose of reserpine(0.5 mg/kg, daily for 14 d) was used to establish a rat depression model. Fluoxetine was used as positive control agent. The effect of AFPR on reserpine-induced ptosis, hypothermia and akinesia, the levels of monoamines and their metabolites, and the activity of monoamine oxidase(MAO) in hippocampus and prefrontal cortex were determined.RESULTS: Administration of AFPR by gavage at 160 and 320 mg/kg significantly reduced the duration of immobility in the FST and TST, and did not affect locomotor activity in the OPT. In the reserpine-induced depression model, AFPR attenuated anhedonia, demonstrated by reversing hypothermia, akinesia and sucrose consumption. AFPR significantly increased the concentration of monoamines, including dopamine, serotonin, noradrenaline and acetylcholine.CONCLUSION: AFPR normalized the metabolism rates of noradrenaline, serotonin and dopamine,and the activity of MAO, which were altered by chronic reserpine exposure. The findings suggest that modulation of the monoaminergic neurotransmitter system likely underlies the antidepressant-like effect of AFPR. | Wei Guining Chu Shifeng Su Qibiao Su Hua Lin Meiyu He Fei Lu Wenjie Lu Guoshou Huang Zhoufeng Tan Xiao Lin Xiao Zeng Xianbiao Wei Baowei Chen Naihong | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 4 |
| 5 | Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis(DISH)显示文摘Diffuse idiopathic skeletal hyperostosis(DISH) is a prevalent noninflammatory spondyloarthropathy characterized by ectopic mineral formation along the anterolateral aspect of the vertebral column, yet little is known about its underlying pathogenesis. Our objective was to evaluate the histopathological features and composition of ectopic mineral within spinal tissues affected by DISH in humans. Thoracic spine segments from six embalmed cadaveric donors(one female and five males;median age 82 years)meeting the radiographic diagnostic criteria for DISH were evaluated using radiological, histological, and physical analyses. Overall,the histological features of ectopic mineralization at individual motion segments were heterogeneous, including regions of heterotopic ossification and dystrophic calcification. Heterotopic ossifications were characterized by woven and lamellar bone,multifocal areas of metaplastic cartilage, and bony bridges along the anterior aspect of the intervertebral disc space. Dystrophic calcifications were characterized by an amorphous appearance, a high content of calcium and phosphorus, an X-ray diffraction pattern matching that of hydroxyapatite, and radiodensities exceeding that of cortical bone. Dystrophic calcifications were found within the anterior longitudinal ligament and annulus fibrosus in motion segments both meeting and not meeting the radiographic criteria for DISH. In summary, our findings indicate that in DISH, ectopic mineral forms along the anterior aspect of the spine by both heterotopic ossification and dystrophic calcification of fibrocartilaginous tissues. Although both types of ectopic mineralization are captured by current radiographic criteria for DISH, dystrophic calcification may reflect a distinct disease process or an early stage in the pathogenesis of DISH. | Dale E.Fournier Patti K.Kiser Ryan J.Beach S.Jeffrey Dixon Cheryle A.Séguin | 2020 | Bone Research2020，8，2： | 4 |
| 6 | Degradation of 2,2′,4,4′-tetrabromodiphenyl ether by Pycnoporus sanguineus in the presence of copper ions显示文摘The degradation of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) by Pycnoporus sanguineus was investigated in order to explore the impact of the heavy metal Cu2+ on BDE-47 decomposition and the subsequent formation of metabolites, as well as to further elucidate the degradation mechanism of BDE-47. An increase in degradation rate from 18.63% to49.76% in the first four days and its stabilization at(51.26 ± 0.08)% in the following days of BDE-47 incubation were observed. The presence of Cu2+ at 1 and 2 mg/L was found to promote the degradation rate to 56.41% and 60.79%, respectively, whereas higher level of Cu2+(≥ 5 mg/L) inhibited the removal of BDE-47. The similar concentration effects of Cu2+ was also found on contents of fungal protein and amounts of metabolites. Both intracellular and extracellular enzymes played certain roles in BDE-47 transportation with the best degradation rate at 27.90% and 27.67% on the fourth and third day, individually. During the degradation of BDE-47, four types of hydroxylated polybrominated diphenyl ethers(OH-PBDEs), i.e., 6′-OH-BDE-47, 5′-OH-BDE-47, 4′-OH-BDE-17, 2′-OH-BDE-28, and two bromophenols, i.e., 2,4-DBP and 4-BP were detected and considered as degradation products. These metabolites were further removed by P. sanguineus at rates of 22.42%,23.01%, 27.04%, 27.96%, 64.21%, and 40.62%, respectively. | Meiqian Wang Hua Yin Hui Peng Mi Feng Guining Lu Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，9： | 4 |
| 7 | Co-metabolic and biochar-promoted biodegradation of mixed PAHs by highly efficient microbial consortium QY1显示文摘Polycyclic aromatic hydrocarbons(PAHs), typical representatives of the persistent organic pollutants(POPs), have become ubiquitous in the environment.In this study, a novel microbial consortium QY1 that performed outstanding PAHs-degrading capacity has been enriched.The degradation characteristics of single and mixed PAHs treated with QY1 were studied, and the effect of biochar on biodegradation of mixed PAHs and the potential of biochar in PAHs-heavy metal combined pollution bioremediation were also investigated.Results showed that, in single substrate system, QY1 degraded 94.5% of 500 mg/L phenanthrene(PHE) and 17.8% of 10 mg/L pyrene(PYR) after 7 days, while in PHE-PYR mixture system, the biodegradation efficiencies of PHE(500 mg/L) and PYR(10 mg/L) reached 94.0%and 96.2%, respectively, since PHE served as co-metabolic substrate to have significantly improved PYR biodegradation.Notably, with the cooperation of biochar, the biodegradations of PHE and PYR were greatly accelerated.Further, biochar could reduce the adverse impact of heavy metals(Cd^(2+), Cu^(2+), Cr_(2)O_(7)^(2-)) on PYR biodegradation remarkably.The sequencing analysis revealed that Methylobacterium, Burkholderia and Stenotrophomonas were the dominant genera of QY1 in almost all treatments, indicating that these genera might play key roles in PAHs biodegradation.Overall, this study provided new insights into the efficient bioremediation of PAHs-contaminated site. | Min Li Hua Yin Minghan Zhu Yuanyuan Yu Guining Lu Zhi Dang | 2021 | Journal of Environmental Sciences2021，33，9： | 4 |
| 8 | 使用微型模块SIP中的集成无源器件显示文摘简介集成无源器件在我们的行业中并不是什么新事物——它们由来已久且众所周知。关键在于,当芯片组将独立的分立无源器件或者是集成无源网络作为其一部分包含在内时,需要对走线寄生效应、器件兼容性和电路板组装等考虑因素进行仔细的设计管理。虽然集成无源器件继续在业界占据重要地位,但只有当它们被集成到系统级封装应用中时才能实现其最重要的价值。 | Mark Murphy Pat Mc Guinness | 2019 | 中国集成电路2019，0，3： | 3 |
| 9 | Effect of accelerated ageing on the performance of high voltage carbon/carbon electrochemical capacitors in salt aqueous electrolyte显示文摘 | Paula Ratajczak Krzysztof Jurewicz Piotr Skowron Qamar Abbas Francois Béguin | 2014 | Electrochimica Acta2014，，： | 3 |
| 10 | Existence of spatiotemporal patterns in the reaction-diffusion predator-prey model incorporating prey refuge显示文摘 | Lakshmi Narayan Guin Benukar Mondal Santabrata Chakravarty | 2016 | International Journal of Biomathematics2016，9，6： | 3 |
| 11 | Thiocyanate-induced labilization of schwertmannite: Impacts and mechanisms显示文摘Schwertmannite is an amorphous iron(III)-oxyhydroxysulfate that forms in acid mine drainage(AMD) environments. The characteristic of high heavy metal adsorption capability makes schwertmannite a potentially useful, environmentally friendly material in wastewater treatment. Unstable schwertmannite is prone to recrystallization.Understanding the mechanisms that induce schwertmannite labilization and affect its capacity to remove heavy metals are of great environmental and geochemical significance.Thiocyanate(SCNˉ) is a hazardous pseudohalide that is also normally found in AMD.However, little is known about the impact of Fe(III)-binding ligand SCNˉ on schwertmannite stability and its subsequent capacity to bind trace elements. Here, we investigated the adsorption of SCNˉ on schwertmannite and subsequent mineral transformation to characterize this little-known process. The appearance of Fe2+indicated that the interactions between schwertmannite and SCNˉ may involve complexation and reduction reactions. Results showed that the majority of the adsorbed-SCNˉ was immobilized on schwertmannite during the 60-days transformation. The transformation rates of schwertmannite increased with increasing concentrations of SCNˉ. Goethite was detected as the dominant transformation product with or without SCNˉ. The mechanisms of SCNˉ-promoted dissolution of schwertmannite can be described as follows:(1) formation of Fe(III)–NCS complexes on the schwertmannite surface and in solution, a process which increases the reactivity of solid phase Fe(III);(2) the extraction of Fe(III) from schwertmannite by SCNˉ and subsequent schwertmannite dissolution; and(3) the formation of secondary minerals from extracted Fe(III). These findings may improve AMD treatment strategies and provide insight into the use and potential reuse of schwertmannite as a trace element sorbent. | Cong Fan Chuling Guo Junhui Zhang Cui Ding Xiaofei Li John R.Reinfelder Guining Lu Zhenqing Shi Zhi Dang | 2019 | Journal of Environmental Sciences2019，31，6： | 3 |
| 12 | Supercapacitors based on conducting polymers/nanotubes composites显示文摘 | E. Frackowiak V. Khomenko K. Jurewicz K. Lota F. Béguin | 2005 | Journal of Power Sources2005，，2： | 2 |
| 13 | Prospective Quality Initiative to Maximize Dysphagia Screening Reduces Hospital-Acquired Pneumonia Prevalence in Patients With Stroke显示文摘 | W. Lee Titsworth Justine Abram Amy Fullerton Jeannette Hester Peggy Guin Michael F. Waters J Mocco | 2013 | Stroke2013，，11： | 2 |
| 14 | The RAS-RAL axis in cancer: evidence for mutationspecific selectivity in non-small cell lung cancer显示文摘激活的地岬变化在人的肿瘤是普通的。这些变化经常是为到治疗和随后的差的预后的抵抗的标记。到目前为止,指向地岬下游地表明小径的 RAF-MEK-ERK 和 PI3K-AKT 是唯一的在怀有地岬变化的癌症病人的治疗答应途径。RAL GTPase,地岬的另一个下游的受动器,也为地岬异种癌症的治疗被看作一种治疗学的选择。RAL GTPase 家庭包括 RALA 和 RALB,它能在不同肿瘤模型有分叉或类似的功能。非小的房间肺癌症(NSCLC ) 上的最近的研究证明了不同地岬变化有选择地激活特定的受动器小径。这观察在另外的肿瘤组织类型要求更宽广的确认,但是如果真,将由根据地岬的类型指向特定的下游的地岬受动器提供一条新途径给地岬异种癌症病人的治疗变化。它也建议 RAL GTPase 抑制将是为怀有地岬 glycine 到半胱氨酸(G12C ) 或 glycien 到缬氨酸(G12V ) 的肿瘤的重要治疗策略变化,它通常在 NSCLC 和胰腺的癌症被发现。 | Sunny GUIN | 2015 | Acta Pharmacologica Sinica2015，36，3： | 2 |
| 15 | State of hydrogen electrochemically stored using nanoporous carbons as negative electrode materials in an aqueous medium显示文摘 | F. Béguin M. Friebe K. Jurewicz C. Vix-Guterl J. Dentzer E. Frackowiak | 2006 | Carbon2006，，12： | 2 |
| 16 | Laboratory standardization of a large international clinical trial:the DAIS experience显示文摘 | Guinness C Seccombe DW Frohlich J | 2000 | Clin Biochem2000，33，： | 1 |
| 17 | Carbon materials for the electrochemical storage of energy in capacitors显示文摘 | Frackowiak E Béguin F | 2001 | Carbon2001，39，： | 1 |
| 18 | Magnetically separable Pd catalyst for highly selective epoxide hydrogenolysis under mild conditions 显示文摘 | Guin D Baruwati B Manorama S V | 2007 | Org Let2007，9，7： | 1 |
| 19 | Great expectation: dominance, breeding success and offspring sex ratio in red deer 显示文摘 | Clutton-Back T H Albon S D Guinness F E | 1986 | Anim Behav1986，34，： | 1 |
| 20 | D-penicillamine-induced autoimmunity in the brown Norway rat:role for both T and non-T splenocytes in adoptive transfer of tolerance显示文摘 | Séguin B Masson MJ Uetrecht J | 2004 | Chem Res Toxicol2004，17，10： | 1 |
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