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| 1 | Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes显示文摘AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response. | Andreína Fernandes Adriana Pesci-Feltri Isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti | 2018 | World Journal of Clinical Oncology2018，9，7： | 5 |
| 2 | The chicken Il-I receptor:differential evolution of the cytoplasmic and extracellular domains显示文摘 | GUIDA S HEGUY A MELLI M | 1992 | Gene1992，111，： | 1 |
| 3 | Parametric study of a SPH high velocity impact analysis-A birdstrike windshield application显示文摘 | Grimaldi A Sollo A Guida M Marulo F | | 0，，： | 1 |
| 4 | Independent role of left ventricular global longitudinal strain in predicting prognosis of chronic heart failure patients 显示文摘 | lacoviello M Puzzovivo A Guida P | 2013 | Echoeardiography2013，30，7： | 1 |
| 5 | Tyrosinase gene expression in the Kupffer cells of Rana esculenta L显示文摘 | Guida G Gallone A Maida I | | 0，，06： | 1 |
| 6 | Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery : a prospective, randomized, controlled study 显示文摘 | Guida M Acunzo G Di Spiezio Sardo A | 2004 | Hum Reprod2004，19，6： | 1 |
| 7 | Compost from organic solid waste: Quality assessment and European regulations for its sustainable use显示文摘 | Cesaro A Belgiorno V Guida M | 2015 | Resources Conservation and Recycling2015，94，： | 1 |
| 8 | Body mass index and bioelec?trical vector distribution in 8-year-old children显示文摘 | Guida B Pietrobelli A Trio R | 2008 | Nutr Metab Car?diovasc Dis2008，18，： | 1 |
| 9 | Effectiveness of auto-erosslinked hyaluronie acid gel in the prevention of intrauterine adhesions after hysteroseopie surgery: a prospective, randomized, eontrolled study显示文摘 | Guida M Aeunzo G Di Spiezio Sardo A | 2004 | Hum Reprod2004，19，6： | 1 |
| 10 | Prevention of venous thromboembolism in medical patients with thrombocytopenia or with platelet dysfunction:a review of the literature显示文摘 | Tufano A Guida A Minno MN | 2011 | Semin Thromb Hemost2011，37，3： | 1 |
| 11 | Ifosfamine plus mitoxantrone as salvage treatment in non-Hodgkin's lymphomas显示文摘 | Loruaso V Paradiso A Guida M | 1991 | Am J Clin Oncol1991，14，6： | 1 |
| 12 | Efficient simulation of hybrid stripmap spotlight SAR raw signals from extended scenes 显示文摘 | FRANCESCHETTI G GUIDA R IODICE A | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，11： | 1 |
| 13 | Mechanism of Action of Sodium Hypochlorite an Fits Effects on Dentin显示文摘 | Guida A | 2006 | Minerva Stomatol2006，55，9： | 1 |
| 14 | Ifosfamide plus mitoxantrone as salvage treatment in non-Hodgkin's lymphomas显示文摘 | Lorubbo V Paradiso A Guida M | 1991 | Am J Clin Oncol1991，14，6： | 1 |
| 15 | T lymphocyte activation is associated with viral replication in chronic hepatitis B virus infection of childhood显示文摘 | Vegnente A Guida S Lobo-yeo A | 1991 | Clin Exp Immunol1991，84，2： | 1 |
| 16 | Correlation between biofilm formation and the hypoxic response in Candida parapsilosis显示文摘 | Rossignol T Ding C Guida A | 2009 | Eukaryot Cell2009，8，55： | 1 |
| 17 | Biweekly oxalipla- tin, raltitrexed, 5 - fluorouracil and folinic acid combination chem- otherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I - II study 显示文摘 | AVALLONE A DELRIO P GUIDA C | 2006 | Br J Cancer2006，94，12： | 1 |
| 18 | A Haptic-based Approach to Virtual Training for Aerospace Industry 显示文摘 | Abate A F Guida M Leoncini P | 2009 | Journal of Visual Languages and Computing (S 1045-926X)2009，20，5： | 1 |
| 19 | Reliability of DHPLC in mutational screening of hereditary hearing loss alleles显示文摘 | COLOSIMO A GUIDA V DE LUCA A | 2002 | Hum Mutat2002，19，： | 1 |
| 20 | Vaginoscopic versus traditional office hysteroscopy:a randomized controlled study显示文摘 | Guida M Di Spiezio Sardo A Aeunzo G | | 0，，12： | 1 |
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