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| 1 | Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination显示文摘髓鞘形成是一个包括协同性的胞吐、内吞、mRNA转运和细胞骨架的动态变化的复杂过程。尽管髓鞘的异常在溶酶体贮积症中很常见,但对溶酶体在髓鞘形成和维持中所扮演的角色仍不清楚。本文发现Schwann细胞中的晚期内涵体/溶酶体包含大量的髓鞘蛋白P0,含量占超过一半的外周神经系统中的致密髓鞘的总蛋白并且在不同的刺激下表现出Ca2+依赖性的胞吐作用。Rab27a(一种将分泌溶酶体运输至细胞膜的小GTP酶)下调,极大地阻碍了Schwann细胞中的溶酶体胞吐作用,减少了再生坐骨神经的髓鞘形成。这些发现强调了Schwann细胞中溶酶体的新角色,提示调节Schwann细胞中的溶酶体胞吐作用在外周神经系统中有很重要的生理和病理意义。 | GANG CHEN ZHIJUN ZHANG ZHONGYA WEI QIONG CHENG XIA LI WEI LI SHUMIN DUAN AND XIAOSONG GU | 2012 | 神经损伤与功能重建2012，7，3： | 3 |
| 2 | Improvement of the chirality near avoided resonance crossing in optical microcavity显示文摘Chirality is one of the important phenomena at the vicinity of exceptional point(EP). The conventional understanding is that the chirality is determined by asymmetrical scattering efficiency(?), which reaches to zero only when the resonance approaches EP. Here we study the possibility to enhance the chirality in open systems with a more robust mechanism. By combining chirality with avoided resonance crossing, we show that the chirality and ? can be dramatically modified. Taking a spiral shaped annular cavity as an example, we show that the chirality of optical resonances can be significantly improved when two sets of chiral states approach each other. The imbalance between counterclockwise(CCW) components and clockwise(CW) components has been enhanced by more than an order of magnitude. Our research provides a new route to tailor and control the chirality in open systems. | SONG QingHai GU ZhiYuan ZHANG Nan WANG KaiYang YI Ning Bo XIAO ShuMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 1 |
| 3 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 4 | Analysis of a diverse global Pisum sp. collection and comparison to a Chinese local P. sativum collection with microsatellite markers显示文摘 | Xuxiao Zong Robert J. Redden Qingchang Liu Shumin Wang Jianping Guan Jin Liu Yanhong Xu Xiuju Liu Jing Gu Long Yan Peter Ades Rebecca Ford | 2009 | Theoretical and Applied Genetics2009，，2： | 1 |
| 5 | Suggestion on further strengthening ultra-low emission standards for PM emission from coal-fired power plants in China显示文摘China has established the largest clean coal-fired power generation system in the world by accomplishing the technological transformation of coal-fired power plants(CFPPs)to achieve ultra-low emission.The potential for further particulate matter(PM)emission reduction to achieve near-zero emission for CFPPs has become a hotspot issue.In this study,PM emission from some ultra-low emission CFPPs adopting advanced air pollutant control technologies in China was reviewed.The results revealed that the average filterable particulate matter(FPM)concentration,measured as the total particulate matter(TPM)according to the current national monitoring standard,was(1.67±0.86)mg/m^(3),which could fully achieve the ultra-low emission standard for key regions(5 mg/m^(3)),but that achieving the near-zero emission standard was difficult(1 mg/m^(3)).However,the condensable particulate matter(CPM),with an average concentration of(1.06±1.28)mg/m^(3),was generally ignored during monitoring,which led to about 38.7%underestimation of the TPM.Even considering both FPM and CPM,the TPM emission from current CFPPs would contribute to less than 5%of atmospheric PM_(2.5) concentrations in the key cities and regions in China.Therefore,further reduction in FPM emission proposed by the near-zero emission plan of CFPPs may have less environmental benefit than emission control of other anthropogenic sources.However,it is suggested that the management of CPM emission should be strengthened,and a national standard for CPM emission monitoring based on the indirect dilution method should be established for CFPPs.Those measurements are helpful for optimal operation of air pollutant control devices and continuously promoting further emission reduction. | Jianguo Deng Shumin Wang Jiawei Zhang Yi Zhang Jingkun Jiang Yongzheng Gu Tao Han Lei Feng Jian Gao Lei Duan | 2023 | Journal of Environmental Sciences2023，，1： | 1 |
| 6 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 7 | Open and close-ended CoMoS_(3) nanotubes for hydrogen evolution in acidic and basic conditions显示文摘Electrochemical hydrogen evolution reaction(HER) is a promising route to harvest high-purity hydrogen(H_(2)).Efficient and selective energy transformations rely on the development of novel catalytic materials in terms of compositions and structures that survive under harsh conditions.This study focuses on a unique nanostructured CoMoS_(3) catalyst for HER under strong acidic and basic electrolyte.The morphologies of the catalysts are fine-tuned by altering reaction times in a hydrothermal reaction.Limited reaction time generates twisted thin-sheet CoMoS_(3)(12 h),which spins into a nanotube with an extended synthetic time(16 h).As the reaction time increases to 20 h,the CoMoS_(3) composite creates open-ended nanotubes,facilitating reactants to penetrate and react actively in the inner space of the nanotubes.Further,prolonged reaction time(24 h) results in the formation of the close-ended CoMoS_(3) nanotubes.We find out that the open-ended structure plays an important role in achieving fast kinetics as well as creating more active sites in HER reaction.The catalyst delivers a profound performance under both acidic and basic conditions,with overpotentials of 93 mV and 115 mV(at a current density of 10 mA/cm^(2)) in the acidic and basic electrolytes,respectively.Moreover,it shows superior long-term durability in both solutions.This work will provide a great foundation for understanding the morphology effect with the same composited catalyst towards energy conversion reactions,not limited to HER. | Yuan Li Xuewei Hou Jing Gu Veronika Mikhaylova Kangli Chen Hongming Zhang Shumin Han | 2021 | Journal of Energy Chemistry2021，30，6： | 0 |
| 8 | Function Analyses of Geographic Information System on Rural Distribution Network显示文摘With the actuality and characteristic and requirement of rural power enterprise distribution network management, this article introduced the function of geographic information system on the framework of distribution network, in order to develop rural distribution network. | FANG Junlong FAN Yongcun ZHANG Chunmei GU Shumin | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，2： | 0 |
| 9 | Pepper variome reveals the history and key loci associated with fruit domestication and diversification显示文摘Pepper(Capsicum spp.)is an important vegetable crop that provides a unique pungent sensation when eaten.Through construction of a pepper variome map,we examined the main groups that emerged during domestication and breeding of C.annuum,their relationships and temporal succession,and the molecular events underlying the main transitions.The results showed that the initial differentiation in fruit shape and pungency,increase in fruit weight,and transition from erect to pendent fruits,as well as the recent appearance of large,blocky,sweet fruits(bell peppers),were accompanied by strong selection/fixation of key alleles and introgressions in two large genomic regions.Furthermore,we identified Up,which encodes a BIG GRAIN protein involved in auxin transport,as a key domestication gene that controls erect vs pendent fruit orientation.The up mutation gained increased expression especially in the fruit pedicel through a 579-bp sequence deletion in its 5′upstream region,resulting in the phenotype of pendent fruit.The function of Up was confirmed by virus-induced gene silencing.Taken together,these findings constitute a cornerstone for understanding the domestication and differentiation of a key horticultural crop. | Yacong Cao Kang Zhang Hailong Yu Shumin Chen Donghui Xu Hong Zhao Zhenghai Zhang Yinqing Yang Xiaozhen Gu Xinyan Liu Haiping Wang Yaxin Jing Yajie Mei Xiang Wang Véronique Lefebvre Weili Zhang Yuan Jin Dongliang An Risheng Wang Paul Bosland Xixiang Li IIan Paran Baoxi Zhang Giovanni Giuliano Lihao Wang Feng Cheng | 2022 | Molecular Plant2022，15，11： | 0 |
| 10 | In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesiclemediated targeting显示文摘The development of efficient contrast agents for tumor-targeted imaging remains a critical challenge in the clinic.Herein,we proposed a tumor-derived extracellular vesicle(EV)-mediated targeting approach to improve in vivo tumor imaging using ternary downconversion nanoparticles(DCNPs)with strong near infrared II(NIR-II)luminescence at 1,525 nm.The EVs were metabolically engineered with azide group,followed by in vivo labeling of DCNPs through copper-free click chemistry.By taking advantage of the homologous targeting property of tumor derived EVs,remarkable improvement in the tumor accumulation(6.5%injection dose(ID)/g)was achieved in the subcutaneous colorectal cancer model when compared to that of individual DCNPs via passive targeting(1.1%ID/g).Importantly,such bioorthogonal labeling significantly increased NIR-II luminescence signals and prolonged the retention at tumor sites.Our work demonstrates the great potential of EVs-mediated bioorthogonal approach for in vivo labeling of NIR-II optical probes,which provides a robust tool for tumor-specific imaging and targeted therapy. | Hui Li Yanfeng Zhong Shumin Wang Menglei Zha Wenxing Gu Guoyong Liu Bohan Wang Zhendong Yu Yu Wang Kai Li Yuxin Yin Jing Mu Xiaoyuan Chen | 2023 | Nano Research2023，16，2： | 0 |
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