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| 1 | Isolation and characterization of bioactive fungi from shark Carcharodon carcharias' gill with biopharmaceutical prospects显示文摘Until recently,little was known about the fungi found in shark gills and their biomedicinal potential. In this article,we described the isolation,bioactivity,diversity,and secondary metabolites of bioactive fungi from the gill of a shark(Carcharodon carcharias). A total of 115 isolates were obtained and grown in 12 culture media. Fifty-eight of these isolates demonstrated significant activity in four antimicrobial,pesticidal,and cytotoxic bioassay models. Four randomly selected bioactive isolates inhibited human cancer cell proliferation during re-screening. These active isolates were segregated into 6 genera using the internal transcribed spacer-large subunit(ITS-LSU) rDNA-sequence BLAST comparison. Four genera,Penicillium,Aspergillus,Mucor,and Chaetomium were the dominant taxa. A phylogenic tree illustrated their intergenera and intragenera genetic diversity. HPLC-DAD-HRMS analysis and subsequent database searching revealed that nine representative strains produced diverse bioactive compound profiles. These results detail the broad range of bioactive fungi found in a shark's gills,revealing their biopharmaceutical potential. To the best of our knowledge,this is the first study characterizing shark gill fungi and their bioactivity. | 张翼 韩金媛 冯妍 穆军 鲍海燕 Andreas KULIK Stephanie GROND | 2016 | Chinese Journal of Oceanology and Limnology2016，34，1： | 2 |
| 2 | 早产儿小脑损伤的超声与MRI检出率及影像学表现显示文摘目的以MR影像为参考标准.探讨一组过早产儿经前囟(AF)常规头颅超声(US)并补充经乳突囟(MF)和后囟(PF)的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿(小于32周)在新生儿期行多次超声检查,分别采用经AF、PF和MF声窗影像。其中59例在同等月龄段行MRI检查。 | S.J.Steggerda L.M.Leijser F.T.Wiggers-de Brune J.van der Grond F.J.Walther G.van Wezel-Meijler 秦乃姗 | 2009 | 国际医学放射学杂志2009，32，5： | 2 |
| 3 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 4 | Circleof Willis collateral flowinvestigated by magnetic resonance an-giography显示文摘 | Harkamp MJ van Der Grond J van Everdingen KJ | 1999 | Stroke1999，30，12： | 1 |
| 5 | Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes显示文摘 | Manschot SM Brands AM van der Grond J | 2006 | Diabete2006，55，4： | 1 |
| 6 | Towards a stronger simulation support for engine control design:a meth- odological point of view显示文摘 | ALBRECHT A GROND|N O LE BERR F | 2007 | Oil & Gas Science and Technology-Revue De L Institut Francais Du Petrole2007，62，4： | 1 |
| 7 | Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia显示文摘 | Wolf-Dieter Heiss Lutz W. Kracht Alexander Thiel Martin Grond | 2001 | Brain2001，，： | 1 |
| 8 | A comparison of opioid-re- lated adverse events with fentanyl iontophoretic transdermal system versus morphine intravenous patient-controlled analgesia in acute postoperative pain 显示文摘 | VISCUSI ER GROND S DING L | 2015 | Pain Manag2015，6，1： | 1 |
| 9 | Laparoseopic versus open total mesoreetal excision: a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
| 10 | A new treatment option for chronic cancer pain显示文摘 | Zech D F Lehmann K A Grond S A | 1994 | Eur J Pain Cure1994，1，1： | 1 |
| 11 | Flow related anaerobic metabolic changes in patients with severe stenosis of internal carotid artery显示文摘 | van der Grond J Eikelboom BC Mali WT | 1996 | Stroke1996，27，11： | 1 |
| 12 | Value of1H-MRS Using Different Echo Times in Neonates with Cerebral Hypoxia-Ischemia显示文摘 | Roelants VRAM Van der Grond J De VLS | 2001 | Pediatric Research2001，49，： | 1 |
| 13 | Probability of regaining dexterity in the flaccid upper limb:impact of severity of paresis and time since onset in acute stroke显示文摘 | Kwakkel G Kollen BJ van der Grond J | 2003 | Stroke2003，34，9： | 1 |
| 14 | Validation of World Health Or- ganization Guidelines for cancer pain relief: a 10-year prospective study 显示文摘 | Zeeh DF Grond S Lynch J | 1995 | Pain1995，63，1： | 1 |
| 15 | Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes显示文摘 | Manschot SM Brands AM van der Grond J | 2006 | Diabetes2006，55，4： | 1 |
| 16 | 31p Magnetic resonance spectroscopy of the liver:correlation with standardized serum,clinical,and histological changes in diffuse liver disease显示文摘 | Hall HW Grond JV Hattum JV | 1995 | Hepalology1995，21，： | 1 |
| 17 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | J Colorectal Dis2005，，05： | 1 |
| 18 | Clinical Pharmacology of Tramadol显示文摘 | Stefan Grond Armin Sablotzki | 2004 | Clin Pharmacokinet2004，43，13： | 1 |
| 19 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
| 20 | Laparoscopic versus open total mesorectal excision:a case-control study显示文摘 | Breukink SO Pierie JP Grond AJ | 2005 | Int J Colorectal Dis2005，20，5： | 1 |
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