|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Proligerative inflammatoryatrophy of the prostate:implications for prostatic carcinogenesis显示文摘 | De Marzo AM Marchi VL Epstein JI | 1999 | Am J Pathol1999，155，6： | 1 |
| 3 | Skull base cephalometrie changes in cranial expansion by springs 显示文摘 | deFaria Valle Dornelles R Cardim VL de Campos Fonseca Pinto AC | 2011 | J CraniofacSurg2011，22，： | 1 |
| 4 | Duration of serologic response to five viral antigens in dogs显示文摘 | Mouzin DE Lorenzen M J Haworth JD King VL | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 5 | Hepati- tis C infection among intravenous drug users attending therapy programs in Cyprus 显示文摘 | Demetriou VL Van De Vij ver DA Hezka J | 2010 | J Med Virol2010，82，2： | 1 |
| 6 | Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis 显示文摘 | De Matzo AM Marchi VL Epstein JI | 1999 | Am J Pathol1999，155，6： | 1 |
| 7 | Abnormal regulation of DNA methyltranderase expression during colorectal carcinogenesis 显示文摘 | De Marzo AM Marchi VL Yang ES | 1999 | Cancer Res1999，59，16： | 1 |
| 8 | Replacement of the aortic root in patients with Marfan’s syndrome显示文摘 | GOTT VL GREENE PS ALEJO DE | 1999 | N Engl J Med1999，340，17： | 1 |
| 9 | Centrilobular fibrosis:a novel histological pattern of idiopathic interstitial pneumonia显示文摘 | de Carvalho ME Kairalla RA Capelozzi VL | 2002 | Pathol Res Pract2002，198，9： | 1 |
| 10 | Endothelial dysfunction and hypertensive vasoconstriction显示文摘 | De Artinano AA Gonzalez VL | 1999 | Pharmacol Res1999，40，2： | 1 |
| 11 | Human liver glyco- gen phosphorylase inhibitors bind at a new allosteric site 显示文摘 | Rath VL Ammirati M Danlcy DE | 2007 | Chem Biol2007，7，9： | 1 |
| 12 | Interactions of' the Human Pathngenie Brucella Species with Their Hosts显示文摘 | Atluri VL Xavier MN de Jong MF | 2011 | Annu Rev Miern- hio12011，65，： | 1 |
| 13 | Replacement of the aortic root in Patients with Marfan's syndrome显示文摘 | Gott VL Greene PS Alejo DE | 1999 | N Engl J Med1999，340，17： | 1 |
| 14 | Growth stimulatory angiotensin Ⅱ type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma显示文摘 | De Paepe B Verstraeten VL De Potter CR | 2001 | Histochem Cell Biol2001，116，3： | 1 |
| 15 | Mechanical heart valves: 50 years of evolution 显示文摘 | Gott VL Alejo DE Cameron DE | 2003 | The Annals of Thoracic Surgery2003，76，6： | 1 |
| 16 | The tetrapartite synapse: path to CNS sensitization and chronic pain 显示文摘 | De Leo JA Tawfik VL LaCroix-Fralish ML | 2006 | Pain2006，122，12： | 1 |
| 17 | A gene-expression signature as a predictor of survival in breast cancer显示文摘 | Van De Vijver MJ He YD Van'T VL et 01 | 2002 | N Engl J Med2002，347，25： | 1 |
| 18 | Composite graft repair of Marfan aneurysm of the ascending aorta:results in 100 patients显示文摘 | Gott VL Pyeritz RE Cameron DE | 1991 | Ann Thorac Surg1991，52，1： | 1 |
| 19 | The tetrapartite synapse: path to CNS sensitization and chronic pain显示文摘 | De Leo JA Tawfik VL and LaCroix-Fralish ML | 2006 | Pain2006，122，： | 1 |
| 20 | Secondary hyperparathyroidism and its relationship with sarcopenia in elderly women显示文摘 | De Souza Genaro P De Medeiros Pinheiro M Szejnfeld VL | 2015 | Arch Gerontol Geriatr2015，60，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员