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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Validation of Inter- national Classification of Functioning, Disability, and Health (ICF) Core Sets for early postacute rehabilitation fa- cilities: comparisons with three other functional measures 显示文摘 | Grill E Stucki G Scheuringer M | 2006 | Am J Phys Med & Rehabil2006，85，8： | 1 |
| 3 | Compari-son of novel pro-BNP1-108and standard BNP assays in heart failure patients显示文摘 | MILLER W L GRILL D E JAFFE A S | 2012 | Clinica Chimica Acta2012，413，： | 1 |
| 4 | Scales could be developed based on simple clinical ratings of ICF Core Set categories显示文摘 | Grill E Stucki G | 2008 | Clin J Epidemiol2008，，： | 1 |
| 5 | The ICF categories identified in nursing interventions administered to neurological patients with post-acute rehabilitation needs显示文摘 | Boldt C Braeh M Grill E | 2005 | Disability and Rehabilitation2005，27，78： | 1 |
| 6 | Relay and control of ab- scisic acid signaling显示文摘 | HIMMELBACH A YANG Y GRILL E | 2003 | Current Opinion in Plant Biology2003，6，5： | 1 |
| 7 | Operationalization and Rehabilitation Testing of ICF Categories Relevant for Physiotherapist's Inventions in Acute Hospital显示文摘 | Grill E Gloor-Juzi T Huber EO | 2011 | J Rehabil Med2011，43，2： | 1 |
| 8 | Hydrogen peroxide is a regulator of ABI1,a protein phosphatase 2C from Arabidopsis显示文摘 | Meinhard M Grill E | 2001 | FEBS Lett2001，508，： | 1 |
| 9 | Phytochelatins:the principal heavy-metal complexing peptides of higher plants显示文摘 | GRILL E WINNACKER E L ZENK M H | 1985 | Science1985，230，： | 1 |
| 10 | Incidence and prognostic importance of acute renal failure after pereutaneous coronary intervention显示文摘 | RIHAL C S TEXTOR S C GRILL D E | 2002 | Circulation2002，105，： | 1 |
| 11 | A protein phosphatase 2C involved in ABA transduction in Arabisopsis thaliana显示文摘 | Meyer K Leube M P Grill E | | 0，，： | 1 |
| 12 | Detoxifieation of arsenic by phytochelatins in plants显示文摘 | Schmoger M E V Oven hi Grill E | 2000 | Plant Physiology2000，122，： | 1 |
| 13 | Formation and Propagation of p n Junction in p-(HgCd)Te Caused by Dry Etching 显示文摘 | Belas E Grill R Franc J | 2002 | Journal of Electronic Materials2002，31，3： | 1 |
| 14 | Altered thyroid function in severely injured patients显示文摘 | Grill E Strong M Sonnad SS | 2013 | J Surg Res2013，179，1： | 1 |
| 15 | Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention显示文摘 | Rihal C S Textor S C Grill D E | 2002 | Circulation2002，105，： | 1 |
| 16 | Incidence and prognostic importance of acute renal failure after pereutaneous coronary intervention显示文摘 | Rihal C S Textor S C Grill D E | 2002 | Circulation2002，105，19： | 1 |
| 17 | Effect of smoking status on the long term outcome after successful percutaneous coronary revascularization显示文摘 | Hasdai D Garratt K N Grill D E | 1997 | N Eng J Med1997，336，11： | 1 |
| 18 | Phytochelatins, a class of heavy-metal-binding peptides from plants, are function- ally analogous to metallothioneins 显示文摘 | GRILL E WINNACKER E L ZENK M H | 1987 | Proceedings of the Na- tional Academy of Sciences of the United States of America1987，84，2： | 1 |
| 19 | Phytochelatins,the heavymetalbinding peptides of plants,are synthesized from glutathione by a specificglutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)显示文摘 | Grill E Loffler S Winnacker E L | 1989 | Proceedings of the National Academy of Sciences1989，86，18： | 1 |
| 20 | Effect of age on the outcome of angioplasty for acute myocardial infarction among patients treated at the Mayo Clinic显示文摘 | Mandeep Singh Verghese Mathew Kirk N Garratt Peter B Berger Diane E Grill Malcolm R Bell Charanjit S Rihal David R Holmes | 2000 | The American Journal of Medicine2000，，3： | 1 |
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