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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | 中、低收入国家卫生智囊团的实践影响政策变化显示文摘近年来,中、低收入国家独立卫生政策研究机构的数量与日俱增,原因在于政府研究能力有限和民主化进程中的压力。本研究的目标是:(1)调查中﹑低收入国家中卫生政策研究机构对卫生政策的议程设置﹑制定﹑执行、监管和评估所作的贡献;(2)评估包括组织形式和结构在内的哪些因素支持中﹑低收入国家的卫生政策研究机构对卫生政策发挥积极作用。本研究在孟加拉﹑加纳﹑印度﹑南非﹑乌干达和越南选取了6家卫生政策研究机构开展案例研究,研究对象包括两个非政府组织、两所大学和两个政府办政策研究机构。案例研究通过文献查阅、财务信息分析、对工作人员和其他利益相关人员进行半结构式访谈,以及对结论草案进行多次反馈等方式开展。其中有些机构对他们各自国家的政策发展作出了巨大贡献。这些机构都积极建言献策,多数从事与政策相关的研究,而开展政治对话﹑系统评价或委托性研究的机构则相对较少。这些机构所开展的工作大多以政府或出资人的需求为导向,多数机构的主要成果一般为研究报告,经常与面向政府官员的口头汇报相结合。在支持对政策的有效参与方面,有几个关键因素,其中包括支持性的政策环境﹑管理和财务的相对独立性,以及与决策者建立可增进信任和影响的密切关系。当研究机构与政府之间的正式关系未处在重要位置时,政府内部单位则面临相当大的困难。 | Sara Bennett Adrijana Corluka Jane Doherty Viroj Tangcharoensathlen Walaiporn Patcharanarumol Amar Jesani Joseph Kyabaggu Grace Namaganda A M Zakir Hussain Ama de-Graft Aikins | 2012 | 中国卫生政策研究2012，5，8： | 6 |
| 3 | 天然气自热重整模块化流化床膜反应器的测试显示文摘针对燃料电池等行业对分布式高纯度氢气的需求,研发了一种新型模块化流化床膜反应器用于中小规模天然气水蒸汽自热重整制氢。在一个天然气制氢测试平台上对该反应器进行了中试研究,测试了空气引入方式对床层温度均匀性的影响,钯膜组件及催化剂的工作性能,并将反应器尾气成分与平衡态最小自由能模型预测的结果进行了比较。测试结果表明该新型模块化流化床膜反应器适于天然气自热重整制氢。 | 解东来 Adris A M Lim C J Grace J R | 2009 | 太阳能学报2009，30，5： | 6 |
| 4 | Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin–based combination treatments: Implications for disease control显示文摘 | Grace O Gbotosho Titilope M Okuboyejo Christian T Happi Akintunde Sowunmi | 2011 | Asian Pacific Journal of Tropical Disease2011，，3： | 2 |
| 5 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 6 | Cause-related marketing How generation Y responds 显示文摘 | Cui Yanli Trent Elizabeth S Sullivan Pauline M Matiru Grace N | 2003 | International Journal of Retail & Distribution Management2003，31，67： | 1 |
| 7 | Immortalization of primary human keratinocytes by the helix-loop-helix protein Id-1显示文摘 | Hasskarl J Grace M | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 8 | Therapeutic potential of Lovastatin in mulliple sclerosis显示文摘 | Sena A pedrosa R Grace Morais M | 2005 | J Neurol2005，250，6： | 1 |
| 9 | A fine-grained analysis of facial expression processing in high-functioning adults with autism显示文摘 | Kate H Nancy M Grace LL | | 0，，04： | 1 |
| 10 | TRPA1 agonists evoke coughing in Guinea pig and human volunteers显示文摘 | Birrell MA Belvisi MG Grace M | 2009 | Am J Respir Crit Care Med2009，180，11： | 1 |
| 11 | Respiration in the balance显示文摘 | Rayment M | 2000 | Nature2000，404，： | 1 |
| 12 | Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications 显示文摘 | Wang YS Youngster S Grace M Bausch J Bordens R Wyss DF | 2002 | Adv Drug Deliv Rev2002，54，4： | 1 |
| 13 | Distribution of muhi-phase gas-solid flow across identical parallel cyclones: modeling and experimental study显示文摘 | Masnadi M S Grace J R Elyasi S | 2010 | Sepa- ration and Purification Technology2010，72，1： | 1 |
| 14 | Sequence and spacing of TATA box elements are critical for accurate initiation from the β-phaseolin promoter显示文摘 | GRACE M L CHANDRASEKHARAN M B HALL T C CROWE A J | 2004 | Biological Chemistry2004，279，： | 1 |
| 15 | Acetylcholine in mind:A neurotransmitter correlate of consciousness 显示文摘 | Perry E Walker M Grace J | 1999 | Trends Neurosci1999，22，： | 1 |
| 16 | Recovery characteristics following induction of anaesthesia with a combination of thiopentone andpropofol 显示文摘 | Rashiq S Gallant B Grace M | 1994 | Can J Anaesth1994，41，12： | 1 |
| 17 | Effects of hydrogel/ silver coatings on in vitro adhesion to catheters of bacteria associated with urinary tract infection显示文摘 | AHEAM D G GRACE D T JENNINGS M J | 2000 | Curr Microbiol2000，41，2： | 1 |
| 18 | Acute lym-phoblastic leukemia and Klinefelter's syndrome 显示文摘 | SHAW M P EDEN O B GRACE E | 1992 | Pediatr Hematol Oncol1992，9，： | 1 |
| 19 | Pharmacologic therapy of portal hypertension显示文摘 | Minor M A Grace N D | 2006 | Clin Liver Dis2006，10，3： | 1 |
| 20 | Mierostruetural aspects of the behavior of circulating fluidized beds显示文摘 | Brereton C M H Grace J R | 1993 | Chemical Engineer-ing Science1993，48，14： | 1 |
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