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| 1 | Contrast-enhanced endoscopic ultrasound in discrimination between focal pancreatitis and pancreatic cancer显示文摘瞄准:作为基于微容器的灌注特征把发炎区分开来与胰腺的癌的一个方法评估提高对比的 endosonography。方法:在有怀疑的慢性胰炎的 86 个病人(变老:62+/-12 年;性别:f/m 38/48 ) ,胰腺的损害被常规内视镜的 B 模式,力量 Doppler 超声和提高对比的力量模式检验(日立 EUB 525, SonoVue, 2.4 mL, Bracco ) 用为恶意的损害的下列标准:用常规力量 Doppler 的没有可检测的 vascularisation 在用 SonoVue 提高对比的技术和没有可检测的静脉的容器里面的短距离上的动脉的容器的扫描、不规则的外观损害。如果所有标准是可检测的,恶意的损害被假定[内视镜的超声(EUS ) 指导了的标准答案好针渴望细胞学,操作] 。没有瘤形成的慢性胰炎的标准在 SonoVue 的注射前被定义为没有可检测的 vascularisation,在在 SonoVue 的注射和动脉、静脉的容器的察觉以后的至少 20 公里的距离上的容器的常规外观。结果:常规 EUS 的敏感和特性为胰腺的癌症分别地是 73.2% 和 83.3% 。与恶意的胰腺的损害和特性在 56 个病人中的 51 个增加到 91.1% 的提高对比的 EUS 的敏感与长期的煽动性的胰腺的疾病在 30 个病人中的 28 个增加了到 93.3% 。结论:提高对比的内视镜的超声改进在慢性胰炎和胰腺的癌之间的区别。 | Michael Hocke Ewald Schulze Peter Gottschalk Theodor Topalidis Christoph F Dietrich | 2006 | World Journal of Gastroenterology2006，12，2： | 43 |
| 2 | The pathogenesis of the meningitis caused byStreptococcus suis:the unresolved questions显示文摘 | Gottschalk M Segura M | 2000 | Vet Microbiol2000，76，3： | 8 |
| 3 | Brugada拟表型:一个新的临床实体显示文摘Brugada拟表型(Brugada phenocopy,BrP)是临床实体,它与真正的Brugada综合征(Brugada syndrome,BrS)具有相同的心电图波形,但前者是由各种临床状况诱发的。在某种相关的潜隐状况下,BrP的特征表现为心前区导联V1~V3呈1型或2型Brugada心电图波形。随着潜隐状况的纠正,这些心电图波形恢复正常。本研究中,我们回顾了BrP的分类、与BrS鉴别的方法及有关BrP病因的最新研究结果。此外,我们提供了BrP国际在线注册的更新数据,并讨论了BrP未来的研究方向。 | Byron H Gottschalk Daniel D Anselm Adrian Baranchuk 蒋祖勋 | 2015 | 江苏实用心电学杂志2015，0，4： | 5 |
| 4 | Apple whole genome sequences:recent advances and new prospects显示文摘In 2010,a major scientific milestone was achieved for tree fruit crops:publication of the first draft whole genome sequence(WGS)for apple(Malus domestica).This WGS,v1.0,was valuable as the initial reference for sequence information,fine mapping,gene discovery,variant discovery,and tool development.A new,high quality apple WGS,GDDH13 v1.1,was released in 2017 and now serves as the reference genome for apple.Over the past decade,these apple WGSs have had an enormous impact on our understanding of apple biological functioning,trait physiology and inheritance,leading to practical applications for improving this highly valued crop.Causal gene identities for phenotypes of fundamental and practical interest can today be discovered much more rapidly.Genome-wide polymorphisms at high genetic resolution are screened efficiently over hundreds to thousands of individuals with new insights into genetic relationships and pedigrees.High-density genetic maps are constructed efficiently and quantitative trait loci for valuable traits are readily associated with positional candidate genes and/or converted into diagnostic tests for breeders.We understand the species,geographical,and genomic origins of domesticated apple more precisely,as well as its relationship to wild relatives.The WGS has turbo-charged application of these classical research steps to crop improvement and drives innovative methods to achieve more durable,environmentally sound,productive,and consumer-desirable apple production.This review includes examples of basic and practical breakthroughs and challenges in using the apple WGSs.Recommendations for“what’s next”focus on necessary upgrades to the genome sequence data pool,as well as for use of the data,to reach new frontiers in genomics-based scientific understanding of apple. | Cameron P.Peace Luca Bianco Michela Troggio Eric van de Weg Nicholas P.Howard Amandine Cornille Charles-Eric Durel Sean Myles ZoëMigicovsky Robert J.Schaffer Evelyne Costes Gennaro Fazio Hisayo Yamane Steve van Nocker Chris Gottschalk Fabrizio Costa David Chagné Xinzhong Zhang Andrea Patocchi Susan E.Gardiner Craig Hardner Satish Kumar Francois Laurens Etienne Bucher Dorrie Main Sook Jung Stijn Vanderzande | 2019 | Horticulture Research2019，6，1： | 3 |
| 5 | Identification and expression of the genes and purification and characterization of the gene products involved in reactivation of coenzyme B12-dependent glycerol dehydratase of Citrobacter freundii显示文摘 | Seifert C Bowien S Gottschalk G | | Eur J Biochem0，20，： | 2 |
| 6 | Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer显示文摘 | Stefan Eser Nina Reiff Marlena Messer Barbara Seidler Kathleen Gottschalk Melanie Dobler Maren Hieber Andreas Arbeiter Sabine Klein Bo Kong Christoph W. Michalski Anna Melissa Schlitter Irene Esposito Alexander J. Kind Lena Rad Angelika E. Schnieke Manuel | 2013 | Cancer Cell2013，，： | 2 |
| 7 | Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: Limited role of LOS in apoptosis and pro-inflammatory cytokine release显示文摘 | Bénédicte Bouchet Ghyslaine Vanier Mario Jacques Eliane Auger Marcelo Gottschalk | 2008 | Microbial Pathogenesis2008，，2： | 2 |
| 8 | Addressing concerns about cisplatin application during pregnancy显示文摘 | Malgorzata Lanowska Christhardt K?hler Peter Oppelt Alexander Schmittel Elisabeth Gottschalk Kati Hasenbein Achim Schneider Simone Marnitz | 2011 | Journal of Perinatal Medicine2011，，3： | 2 |
| 9 | Relatedness of Streptococcus suis serotype 2 isolates from different geographical origins as evaluated by molecular fingerprinting显示文摘 | Chatellier S Gottschalk M Higgins R | 1999 | J Clin Microbiol1999，37，36： | 2 |
| 10 | Influence of colour changes and moisture content during banana drying on laser backscattering显示文摘Pre-drying treatments are frequently employed to preserve fruit quality.The objective of this research was to monitor colour changes of banana during drying by laser backscattering and to determine the influence of the fruit discolouration on the light distribution into banana tissue.Moreover,to examine the influence of drying on the laser backscatter,the relationship between moisture content and relative laser area of banana slices was analyzed with different degrees of colour degradation.The experiments were conducted at drying air temperature of 63℃with various pre-treatments like chilling,soaking in ascorbic/citric acid and dipping in distilled water.An untreated sample was used as a control.A laser diode emitting at 670 nm with 3 mW power was used as light source.The backscattering relative laser area was used as an indicator for the light absorption into the tissue.The high result achieved on coefficient of determination R^(2)(>0.93)confirmed linear relationship between relative laser area and moisture content.Treatment with ascorbic acid gave the best prediction of the moisture content with the standard error of 5.7 and 8.8 for the estimated intercept and slope.The results showed a significant difference of lightness(L*values)during drying according to the different treatments.As a result,colour degradation did not have a significant influence on the absorption of light at 670 nm wavelength. | Giuseppe Romano Dimitrios Argyropoulos Klaus Gottschalk Emanuele Cerruto Joachim Müller | 2010 | International Journal of Agricultural and Biological Engineering2010，3，2： | 2 |
| 11 | 基于水文随机方法的大尺度径流空间插值图化研究——淮河流域蚌埠以上区间为例显示文摘跨越不同时空尺度水文径流时空分异性及其图化问题的研究是当前国际地理水文科学研究的热点前沿。本文针对中国湿润流域年平均径流特点,探讨了基于地理相关关系的水文随机方法(Hydro-Stochastic)在大尺度流域上应用的可行性。在淮河流域蚌埠以上区间开展径流空间插值实验,通过对流域出口流量在空间随机场内的分解生成研究区内10km×10km分辨率产流分布图,以及以1km长度为基本单元的河道内径流量图。该方法在描述径流空间分异性的过程中,综合了水文学、地貌学、地理学的特点,以地统计空间插值方法为基础,结合了水量平衡约束以及数据不确定性分析理论,最终输出不同形式的径流空间分异结果。分析表明,径流插值结果能够很好的反映流域内产流的空间分布特征,并满足河道上下游的水量平衡关系。该方法避免了水文模型的复杂性,描述径流时不依赖气象资料,可以方便的在广大地区推广使用。 | 严子奇 夏军 Lars Gottschalk | 2010 | 地理学报2010，65，7： | 2 |
| 12 | New concepts in acute pain therapy: preemptive analgesia显示文摘 | Gottschalk A Smith DS | 2001 | Am Faro Physician2001，63，10： | 1 |
| 13 | Description of six new capsular types (29-34) of Streptococcus suis显示文摘 | Higgins R Gottschalk M Boudreau M | 1995 | J Vet Diagn Invest1995，7，3： | 1 |
| 14 | Prospective evaluation of pain and analgesic use following major elective intracranial surgery显示文摘 | Gottschalk A Berkow LC Stevens RD | 2007 | J Neurosurg2007，106，2： | 1 |
| 15 | Modeled environmental concentrations of engineered nanoma- terials (TiO2, ZnO, Ag, CNT, fullerenes) for different regions 显示文摘 | GOTTSCHALK F SONDERER T SCHOLZ R W NOWACK B | 2009 | Environ Sci Technol2009，43，： | 1 |
| 16 | Identification and expression of the genes and purification and characterization of the gene products involved in reactivation of coenzyme B12-dependent glycerol dehydratase of Citrubacter freundii 显示文摘 | Seifert C Bowien S Gottschalk G | | Eur J Bioc0，，： | 1 |
| 17 | Scale aggregation comparison of flux estimates from Nopex显示文摘 | Gottschalk L Batchvarova E Gryning S E | 1999 | Agri For Meteorol1999，9899，： | 1 |
| 18 | Modeled envi- ronmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, fullerenes)for different regions显示文摘 | Gottschalk F Sonderer T Scholz R W | 2009 | Envi- ronmental Science and Technology2009，43，： | 1 |
| 19 | Resistance to thyrotropin caused by mutations in the thyrotropin receptor gene显示文摘 | Sunthornthepvarakul T Gottschalk M Hayashi Y | | 0，，： | 1 |
| 20 | Sedation depth during spiualanesthesia and the development of postoperative delirium in elderly patientsundergoing hip fracture repair 显示文摘 | Sieber F Zakriya K Gottschalk A | 2010 | Mayo Clinic Proc2010，85，1： | 1 |
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