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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | A new criterion of coal burst proneness based on the residual elastic energy index显示文摘To evaluate the coal burst proneness more precisely,a new energy criterion namely the residual elastic energy index was proposed.This study begins by performing the single-cyclic loading-unloading uniaxial compression tests with five pre-peak unloading stress levels to explore the energy storage characteristics of coal.Five types of coals from different mines were tested,and the instantaneous destruction process of the coal specimens under compression loading was recorded using a high speed camera.The results showed a linear relationship between the elastic strain energy density and input energy density,which confirms the linear energy storage law of coal.Based on this linear energy storage law,the peak elastic strain energy density of each coal specimen was obtained precisely.Subsequently,a new energy criterion of coal burst proneness was established,which was called the residual elastic energy index(defined as the difference between the peak elastic strain energy density and post peak failure energy density).Considering the destruction process and actual failure characteristics of coal specimens,the accuracy of evaluating coal burst proneness based on the residual elastic energy index was examined.The results indicated that the residual elastic energy index enables reliable and precise evaluations of the coal burst proneness. | Fengqiang Gong Yunliang Wang Zhiguo Wang Junfeng Pan Song Luo | 2021 | International Journal of Mining Science and Technology2021，31，4： | 16 |
| 3 | Evidences of rapid erosion driven by climate in the Yarlung Zangbo (Tsangpo) Great Canyon,the eastern Himalayan syntaxis显示文摘Climate and tectonism are both particularly intense in the Yarlung Zangbo (Tsangpo) Great Canyon in the eastern Himalayan syntaxis,which is characterized by the most rapid landscape evolution of anywhere in the world.Thus,the eastern Himalayan syntaxis is one of the best locations to study the interactions between climate and tectonics.This paper investigates the cooling ages of the Doxong La-Baibung profile using apatite fission track (AFT) dating on 11 bedrock samples at elevations ranging from 4210 to 710 m.There are topographic,climatic,metamorphic,and thermochronological gradients in the profile,providing good conditions to study interactions between climate and tectonics.AFT ages ranged from 4.6±0.6 Ma to 1.7±0.3 Ma,and the mean fission track lengths ranged from 11.0 to 12.4 μm.It was found that the cooling rates revealed by AFT ages increased with decreasing elevation.However,the tendency of the cooling rates revealed by the 40 Ar-39 Ar ages was different from that indicated by the AFT ages.Moreover,for most districts of the eastern Himalayan syntaxis,the compiled AFT age distribution correlates well with the annual average precipitation,indicating the coupling of the cooling and erosion rates of the near-surface rock and precipitation.The geothermal history modeling results indicate an obvious increase in the cooling and erosion rate between 1.0 and 0.5 Ma.This age is consistent with other research findings for this time,when the vapor channel of the Yarlung Zangbo Great Canyon began to take effect.These evidences suggest that climate,especially precipitation,has acting as a key factor influencing the rapid cooling and erosion in the Yarlung Zangbo Great Canyon since 1-0.5 Ma. | YU XiangJiang JI JianQing GONG JunFeng SUN DongXia QING JianChun WANG LiNing ZHONG DaLai ZHANG ZhiCheng | 2011 | Chinese Science Bulletin2011，56，11： | 11 |
| 4 | The Exhumation History of North Qaidam Thrust Belt Constrained by Apatite Fission Track Thermochronology:Implication for the Evolution of the Tibetan Plateau显示文摘Determining the spatio-temporal distribution of the deformation tied to the India-Eurasian convergence and the impact of pre-existing weaknesses on the Cenozoic crustal deformation is significant for understanding how the convergence between India and Eurasia contributed to the development of the Tibetan Plateau. The exhumation history of the northeastern Tibetan Plateau was addressed in this research using a new apatite fission track(AFT) study in the North Qaidam thrust belt(NQTB). Three granite samples collected from the Qaidam Shan pluton in the north tied to the Qaidam Shan thrust, with AFT ages clustering in the Eocene to Miocene. The other thirteen samples obtained from the Luliang Shan and Yuka plutons in the south related to the Luliang Shan thrust and they have showed predominantly the Cretaceous AFT ages. Related thermal history modeling based on grain ages and track lengths indicates rapid cooling events during the Eocene-early Oligocene and since late Miocene within the Qaidam Shan, in contrast to those in the Cretaceous and since the Oligocene-Miocene in the Luliang Shan and Yuka region. The results, combined with published the Cretaceous thermochronological ages in the Qaidam Shan region, suggest that the NQTB had undergo rapid exhumation during the accretions along the southern Asian Andean-type margin prior to the India-Eurasian collision. The Cenozoic deformation initially took place in the North Qaidam thrust belt by the Eocene, which is consistent with the recent claim that the deformation of the northeastern Tibetan Plateau initiated in the Eocene as a response to continental collision between India and Eurasia. The immediate deformation responding to the collision is tentatively attributed to the pre-existing weaknesses of the lithosphere, and therefore the deformation of the northeastern Tibetan Plateau should be regarded as a boundary-condition-dependent process. | CHENG Xiaogan LIN Xiubin WU Lei CHEN Hanlin XIAO Ancheng GONG Junfeng ZHANG Fengqi YANG Shufeng | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 10 |
| 5 | Formation reconfiguration in restricted three body problem显示文摘形成在太阳地球的一条光圈轨道附近飞的重构限制了三个身体系统与推动演习被调查。为短时间重构,二推动的演习与分析、数字的方法并且开始结束被调查()方法被证明是一精力最佳二推动的所有( TI )之一重构,和精力消费独立于主要太空船的位置,并且与重构时间减少。然后,基因算法被采用优化精力消费。结果证明最佳的精力与起始、最后的轨道之间的半径差别增加,并且与重构时间减少。 | Shengping Gong Junfeng Li Hexi Baoyin Yunfeng Gao | 2007 | Acta Mechanica Sinica2007，23，3： | 7 |
| 6 | Feasibility analysis of the angular momentum reversal trajectory via hodograph method for high performance solar sails显示文摘In this paper a new phase space of hodograph method is adopted to investigate and better understand the two-dimensional angular momentum reversal(H-reversal) trajectories for high performance solar sails within a fixed cone angle.As the hodograph method and the H-reversal trajectory are not very common,both of them are briefly introduced.The relationship between them are constructed and addressed with a sample trajectory.How the phase space varies according to the sail quality and the fixed sail cone angle is also studied.Through variation of the phase space,the minimum sail lightness number can be obtained by solving a set of algebraic equations instead of a parameter optimization problem.For a given sail lightness number,there are three types of the two-dimensional possible heliocentric motion,including the spiral inward trajectories towards the Sun,the H-reversal trajectories and the directly outward escape trajectories.The boundaries that separate these different groups are easily determined by using the phase space.Finally,the method and procedures to achieve the feasible region of the H-reversal trajectory with required perihelion distance are presented in detail. | ZENG XiangYuan BAOYIN HeXi LI JunFeng GONG ShengPing | 2011 | Science China(Technological Sciences)2011，54，11： | 3 |
| 7 | Solar sailing trajectory optimization with planetary gravity assist显示文摘Significant propellant mass saving can be obtained with the use of complex multiple intermediate flyby maneuvers for conventional propulsion systems,and trip time also decreases for a portion of the proper solar sail missions.This paper discusses the performance of gravity assist(GA)in the time-optimal control problem of solar sailing with respect to sail lightness number and the energy difference between the initial and final orbit in the rendezvous problem in a two-body model,in which the GA is modeled as a substantial change in the velocity of the sailcraft at the GA time.In addition,this paper presents a method to solve the time-optimal problem of solar sailing with GA in a full ephemeris model,which introduces the third body’s gravity in a dynamic equation.This study builds a set of inner constraints that can describe the GA process accurately.Finally,this study presents an example for evaluating the accuracy and rationality of the two-body model’s simplification of GA by comparison with the full ephemeris model. | CAI XingShan LI JunFeng GONG ShengPing | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 3 |
| 8 | Visible and near infrared reflectance spectroscopy for measuring soil heavy metal content as a quick method显示文摘 | Yunzhao WU Jun CHEN Junfeng JI Peng GONG Qilin LIAO Hongrui MA | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 9 | Fuel-optimal trajectory design using solar electric propulsion under power constraints and performance degradation显示文摘The fuel-optimal transfer trajectories using solar electric propulsion are designed considering the power constraints and solar array performance degradation.Three different performance degradation models including linear,positive and negative exponential degradations are used in the analysis of three typical rendezvous missions including Apophis,Venus and Ceres,respectively.The optimal control problem is formulated using the calculus of variations and Pontryagin’s maximum principle,which leads to a bang-bang control that is solved by indirect method combined with a homotopic technique.In demonstrating the effects of the power constraints and solar array performance degradation on the power budget and fuel consumption,the time histories of the power profile and the fuel consumptions are compared for the three missions.This study indicates that it is necessary to consider the power constraints and solar array performance degradation for the SEP-based low-thrust trajectory design,espacially for long-duration outbound flights. | ZHANG Peng LI JunFeng GONG ShengPing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 1 |
| 10 | Phenomenological analysis of B→PP decays with QCD Factorization显示文摘 | Du Dongsheng Gong Haijun Sun Junfeng | 2002 | Phys Rev2002，65，07： | 1 |
| 11 | Passive stability design for the solar sail on displaced orbits 显示文摘 | GONG Shengping LI Junfeng BAOYIN Hexi | 2007 | Journal of Spacecraft and Rockets2007，44，5： | 1 |
| 12 | Analysis of displaced solar sail orbits 显示文摘 | GONG Shengping LI Junfeng BAOYIN Hexi | 2008 | Journal of Guidance Control and Dynamics2008，31，3： | 1 |
| 13 | Fuel consumption for interplanetary missions of solar sailing显示文摘The orbits of solar sails can be changed by adjusting the sail’s attitude through external control torques.The resulting momentum will be changed,either provided by a typical attitude control subsystem or by a propellantless device.This paper investigates the extra momentum input and fuel consumption for a typical attitude control subsystem.The minimum-time transfer trajectories are designed for two rendezvous missions using both indirect and direct methods,generating continuous and discrete attitude histories,respectively.The results show that the momentum variation is almost wholly due to the solar radiation pressure.The feasibility of using tip-mounted microthrusters for attitude control is evaluated.The results show that less than0.1 kg of propellant are required for an interplanetary transfer mission when pulsed plasma thrusters with a specific impulse of700 s and a thrust of 150 mN are mounted at the tip of a 20 m square solar sail.The fuel consumptions of two transfer missions indicate that a tip-mounted pulsed plasma thruster is a viable technique for the attitude control of a solar sail. | GONG ShengPing LI JunFeng | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 1 |
| 14 | Trajectory optimization and applications using high performance solar sails显示文摘The high performance solar sail can enable fast missions to the outer solar system and produce exotic non-Keplerian orbits.As there is no fuel consumption,mission trajectories for solar sail spacecraft are typically optimized with respect to flight time.Several investigations focused on interstellar probe missions have been made,including optimal methods and new objective functions. Two modes of interstellar mission trajectories,namely 'direct flyby' and 'angular momentum reversal trajectory',are compare... | Xiangyuan Zeng,~(a)) Junfeng Li,~(b)) Hexi Baoyin,and Shengping Gong School of Aerospace,Tsinghua University,Beijing 100084,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，3： | 1 |
| 15 | Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration显示文摘Low back pain,mainly caused by intervertebral disc degeneration(IVDD),is a common health problem;however,current surgical treatments are less than satisfactory.Thus,it is essential to develop novel non-invasive surgical methods for IVDD treatment.Here,we describe a therapeutic strategy to inhibit IVDD by injecting hydrogels modified with the extracellular matrix of costal cartilage(ECM-Gels)that are loaded with cartilage endplate stem cells(CESCs).After loaded with CESCs overexpressing Sphk2(Lenti-Sphk2-CESCs)and injected near the cartilage endplate(CEP)of rats in vivo,ECM-Gels produced Sphk2-engineered exosomes(Lenti-Sphk2-Exos).These exosomes penetrated the annulus fibrosus(AF)and transported Sphk2 into the nucleus pulposus cells(NPCs).Sphk2 activated the phosphatidylinositol 3-kinase(PI3K)/p-AKT pathway as well as the intracellular autophagy of NPCs,ultimately ameliorating IVDD.This study provides a novel and efficient non-invasive combinational strategy for IVDD treatment using injectable ECM-Gels loaded with CESCs that express Sphk2 with sustained release of functional exosomes. | Liwen Luo Junfeng Gong Zhouguang Wang Yao Liu Jiaming Cao Jinghao Qin Rui Zuo Hongyu Zhang Shuai Wang Ping Zhao Di Yang Mengjie Zhang Yanqiu Wang Junfeng Zhang Yue Zhou Changqing Li Bing Ni Zhiqiang Tian MingHan Liu | 2022 | Bioactive Materials2022，7，9： | 1 |
| 16 | Transfer trajectories design for a variable lightness solarcraft显示文摘 | Gong Shengping Li Junfeng Baoyin Hexi | | 0，，04： | 1 |
| 17 | The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure显示文摘 | Kaizheng Gong Zhengang Zhang Xiaonin Sun Xin Zhang Aihua Li Junfeng Yan Qiuping Luo Yang Gao Yiliang Feng | 2005 | American Heart Journal2005，，1： | 1 |
| 18 | A new solar sail orbit显示文摘Solar sail is used to achieve a geocentric sun-synchronous frozen orbit.This kind of orbit combines the characteristics of both sun-synchronous orbits and frozen orbits.Furthermore,the impossible orbits for a typical spacecraft such as sun-synchronous orbits whose inclination is less than 90° are also possible for solar sail.To achieve a sun-synchronous frozen orbit,the characteristic acceleration of the sail is chosen properly.In addition,the attitude of the sail is adjusted to keep the sun-synchronous and frozen characteristics.The perturbations including atmosphere drag,third-body gravitational forces and shaded regions are discussed,where the atmosphere drag is cancelled by solar radiation pressure force,third-body gravitational forces have negligible effects on the orbit and the shaded region can be avoided by choosing the classical orbit elements of the sail.At last,a numerical example is employed to validate the sun-synchronous frozen characteristics of the sail. | GONG ShengPing LI JunFeng BAOYIN HeXi SIMO Jules | 2012 | Science China(Technological Sciences)2012，55，3： | 1 |
| 19 | A Spiral Graphene Framework Containing Highly Ordered Graphene Microtubes for Polymer Composites with Superior Through-Plane Thermal Conductivity显示文摘As the power density of electronic devices increases,there has been an urgent demand to develop highly conductive polymer composites to address the accompanying thermal management issues.Due to the ultra-high intrinsic thermal conductivity,graphene is considered a very promising filler to improve the thermal conductivity of polymers.However,graphene-based polymer composites prepared by the conventional mixing method generally have limited thermal conductivity,even under high graphene loading,due to the failure to construct efficient heat transfer pathways in the polymer matrix.Here,a spiral graphene framework(SGF)containing continuous and highly ordered graphene microtubes was developed based on a modified CVD method.After embedding into the epoxy(EP)matrix,the graphene microtubes can act as efficient heat pathways,endowing the SGF/EP composites with a high through-plane thermal conductivity of 1.35 W·m^(-1)·K^(-1) at an ultralow graphene loading of 0.86 wt%.This result gives a thermal conductivity enhancement per 1 wt%filler loading of 710%,significantly outperforming various graphene structures as fillers.In addition,we demonstrated the practical application of the SGF/EP composite as a thermal interface material for efficient thermal man-agement of the light-emitting diode(LED). | Jinrui Gong Xue Tan Qilong Yuan Zhiduo Liu Junfeng Ying Le Lv Qingwei Yan Wubo Chu Chen Xue Jinhong Yu Kazuhito Nishimura Nan Jiang Cheng-Te Lin Wen Dai | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 20 | Developmental Patterns and Gender Differences of Vocal Production in Marmoset Monkeys显示文摘Dear Editor,The common marmoset(Callithrix jacchus),a small New World monkey species,is considered an ideal non-human primate model for studying the evolution and neural mechanism of vocal behavior due to their rich call repertoire and vocal communication[1-3].Especially,the early vocal development of marmoset monkeys has attracted much attention,because newborn marmosets have been shown to exhibit a vocal development trajectory.Within two months after birth,marmosets'vocalizations undergo dramatic changes from cries to adult-like mature calls,a process that is influenced not only by inner physical maturation but also by parental care and feedback[4]. | Ruixin An Chaocheng Lu Chen Wang Liangtang Chang Junfeng Huang Fan Jiang Tian-Le Xu Neng Gong | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
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