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| 1 | Coexistence of acute myocardial infarction with normal coronary arteries and migraine with aura in a female patient显示文摘Acute myocardial infarction with normal coronary arteries is a well known condition,which is typically diagnosed in young patients.Coronary vasospasm,inherited,acquired or malignancy-induced hypercoagulable state,collagen vascular disease and coronary arterial embolism have been considered as underlying etiologic factors.An association between migraine with aura and increased risk of ischemic stroke,angina and myocardial infarction has been demonstrated in studies.Patients with migraine and especially with aura should be followed closely against cardiovascular events even if they are young and do not have traditional risk factors. | Umut Celikyurt Goksel Kahraman Ender Emre | 2011 | World Journal of Cardiology2011，3，7： | 6 |
| 2 | Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal cancer显示文摘AIM: To assess the incidence of MLH1 (the human MutL homologue) and MSH2 (the human MutS homologue) protein expression in Turkish patients with sporadic colorectal cancers and to compare their survival and clinicopathological features. METHODS: We validated the tissue microarray technology in 77 colorectal carcinomas by analyzing the immunohistochemical expression of proteins involved in two main pathways of colorectal carcinogenesis: p53 protein for loss of heterozygosity tumors; MLH1 and MSH2 proteins for microsatellite instability (MSI). RESULTS: Our analysis showed that 29 (39.2%) had loss of MLH1 expression, 5 (6.8%) had loss of MSH2 expression and 2 cases had loss of expression of both proteins. We found that 60% of MSH2-negative tumors were located in the right side of the colon; all MSH2-negative cases were women. In addition, the loss of MSH2 expression was correlated with low p53 expression. Neither MLH1 nor MSH2 expressions were associated with prognosis, although there seemed a tendency of longer survival (71.7 ± 8.65 mo vs 47.08 ± 5.26 mo) for the patients with MLH1-negative versus MLH1-positive carcinomas. There were not significant differences in overall and recurrence-free survival among MLH1/MSH2-positive and -negative cases.CONCLUSION: Our data supports that Turkish patients with MLH1- and MSH2-defective tumors have some distinct features from each other. Although prognostic importance remains controversial, immunohistochemical analysis of mismatch repair genes may be used as a routine histopathological examination of sporadic colorectal carcinomas. | Sibel Erdamar Esra Ucaryilmaz Gokhan Demir Tayfun Karahasanoglu Gulen Dogusoy Ahmet Dirican Suha Goksel | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Frequency,types,and treatment of anemia in Turkish patients with inflammatory bowel disease显示文摘AIM to specify the type and prevalence of anemia along with a treatment approach for inflammatory bowel disease(IBD).METHODS We conducted a retrospective study on 465 patients who were diagnosed with IBD and followed up at our hospital from June 2015 to June 2016 [male: 254, female: 211; average age: 47 ± 14.4; Crohn's disease(CD): 257, Ulcerative Colitis(UC): 208]. Epidemiological and clinical data, such as sex, age, age of diagnosis, type of IBD, disease extension, disease behavior and duration, treatments for IBD and anemia, and surgical history were obtained for each patient. Per World Health Organization guidelines, anemia was diagnosed for males if hemoglobin values were less than 13 g/dL and for females if hemoglobin values were less than 12 g/d L.RESULTS We determined that 51.6% of the patients had anemia, which was more frequent in women then men(64% vs 41.3%, P < 0.001). Anemia frequency was higher in CD cases(57.6%) than in UC cases(44.2%)(P = 0.004). CD involvements were as follows: 48.2% in ileal involvement, 19% in colonic involvement, and 32.8% in ileocolonic involvement. Furthermore, 27.5% of UC patients had proctitis(E1) involvement, 41% ofthem had involvement in left colitis(E2), and 31.5% had pancolitis involvement. There was no significant relationship between anemia frequency and duration of disease(P = 0.55). Iron deficiency anemia(IDA) was the most common type of anemia in this cohort. Moreover, because anemia parameters have not been evaluated during follow-up of 15.3% of patients, the etiology of anemia has not been clarified. Fifty percent of patients with anemia received treatment. Twentythree percent of IDA patients had oral iron intake and forty-one percent of IDA patients had parenteral iron treatment. Fifty-three percent of patients who were suffering from megaloblastic anemia received B12/folic acid treatment.CONCLUSION We found out that almost half of all IBD patients(51.6%) had anemia, the most frequent of which was IDA. Almost half of these patients received treatment. We should increase the treatment rate in our IBD patients that have anemia. | Goksel Bengi Hatice Keyvan Seda Bayrak Durmaz Hale Akpinar | 2018 | World Journal of Gastroenterology2018，24，36： | 4 |
| 4 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 5 | Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis显示文摘 | RAMASWAMYSV AMINAG GOKSELS etal | 2000 | Antimicrob Agents Chemother2000，44，： | 2 |
| 6 | A camera model for natural scene processing 显示文摘 | Parrish Jr E A Goksel A K | 1977 | Pattern Recognition1977，9，： | 1 |
| 7 | Adhesion to metal sulfide surfaces by cells of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans 显示文摘 | Hameit K Goksel A Kock D | 2006 | Hydrometallurgy2006，83，5： | 1 |
| 8 | Subclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: investigating links with ischemic stroke in Turkish patients 显示文摘 | Karakurum Goksel B Karatas M Nebioglu A | 2007 | Neurol Res2007，29，8： | 1 |
| 9 | Efficacy of topical ad- ministration of eprinomectin for treatment of ear mite infes tation in six rabbits显示文摘 | Bulent U Huseyin V Goksel B | 2005 | Veterinary Dermatology2005，16，： | 1 |
| 10 | Adhesion to metal sulfide surfaces by cells of AcidithiobaciUus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans 显示文摘 | Harneit K Goksel A Kock D | 2006 | Hydrometallurgy2006，83，1234： | 1 |
| 11 | Adhesion to metal sulfide surfaces by cells of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans 显示文摘 | Hameit K Goksel A Kock D | 2006 | Hydrometallurgy2006，83，1234： | 1 |
| 12 | Re - moval and recovery of chromium and- chromium speciation with MINTEQA2 显示文摘 | Sevgi Kocaoba Goksel Akcin | 2002 | Talanta2002，57，1： | 1 |
| 13 | Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacteriumtuberculosis显示文摘 | Amin A G Goksel S | 2000 | Antimicrob Agents Chemother2000，44，2： | 1 |
| 14 | Abducens nerve palsy and optic neuritis as initial manifestation in bru- cellosis显示文摘 | Karakurum Goksel B Yerdelen D Karatas M | 2006 | Scand J Infect Dis2006，38，8： | 1 |
| 15 | Hashimoto's thyroiditis is not associated with increased risk of thyroid cancer in patients with thyroid nodules: a single-center prospective study显示文摘 | Anil C Goksel S Gursoy A | 2010 | Thyroid2010，20，6： | 1 |
| 16 | Molecular genetic analysis of nucleotide polymorphisms associated with the thambutol resistance in human isolates of Mycobacterium tuberculosis显示文摘 | Ramaswamy SV Amin AG Goksel S | 2000 | Antimicro Agents chemother2000，44，2： | 1 |
| 17 | Investigation of coastal morphological changes due to river basin characteristics by means of remote sensing and GIS techniques显示文摘 | Seker D Z Goksel C Kabdasli S | 2003 | Water Science and technology2003，，48： | 1 |
| 18 | Adhesion to metal sulfide surfaces by cells of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans 显示文摘 | Harneit K Goksel A Kock D | 2006 | Hydrometallurgy2006，83，： | 1 |
| 19 | Comparison of the treatment performances of blast furnace slag based and gravel based vertical flow wetlands operated identically for domestic wastewater treatment in Turkey 显示文摘 | Korkusuz E A Bekliob M Goksel N D | 2005 | Ecological Engineering2005，24，3： | 1 |
| 20 | Role of host interleukin 1β gene ( IL-1B ) and interleukin 1 receptor antagonist gene ( IL-1RN ) polymorphisms in clinical outcomes in Helicobacter pylori -positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
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