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| 1 | 城市交通一体化走廊管理的理念与实践显示文摘为解决城市交通量快速增长与土地、交通资源之间的突出矛盾,提高交通系统的效益与效率,有必要针对城市重要交通走廊实施一体化走廊管理。首先,对一体化走廊管理的基本概念进行阐释,指出其对于中国城市交通发展的适用性。然后,提出一体化走廊管理的方法,并分别以发达国家城市伦敦、纽约以及发展中国家城市武汉为例,对一体化走廊管理的应用进行了实证分析。最后,总结实践的经验与教训,指出城市领导者的支持、直接利益关系者间协调机制的建立、与交通使用者的双向沟通,以及方案编制的因地制宜有助于一体化走廊管理的规划与实施。 | 方可 Samuel Zimmerman 王伟 Said Dahdah Gladys Frame | 2012 | 城市交通2012，10，3： | 8 |
| 2 | 高温对草鱼热休克蛋白表达的影响显示文摘本实验研究了高温(28℃,33℃,35℃,37℃)胁迫下草鱼(Ctenopharyngodon idellus)体内热休克蛋白(Heat shock protein,HSP)的表达模式以分析高温影响草鱼存活的生理机制。在不同温度下,实时记录草鱼存活状态和呼吸频率,并利用蛋白杂交方法测定热休克蛋白(Hsp70,Hsp73)表达量的变化。结果表明,当水温超过28℃,草鱼存活率随温度升高而降低,在35℃和37℃时全部死亡;呼吸频率随温度升高而升高,各温度间差异显著(P<0.05);温度升高会诱导草鱼肝脏和肌肉中Hsp73表达量升高,表明热休克蛋白的上调表达是草鱼抵御温度应激的重要生理响应机制。 | 宋文华 Gladys Ludevese 董云伟 刘营 董双林 王芳 | 2012 | 海洋湖沼通报2012，，1： | 6 |
| 3 | Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis显示文摘AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain diagnosis.METHODS A retrospective chart review was performed.Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included.Baseline characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were analyzed.Interventions based on CLE findings were also analyzed.We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens.RESULTS A total of 144 patients were included.Of these,51%(74/144) were female.The mean age was 51 years old.In all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,respectively.Cohen's Kappa was 69.20%,thus indicating good agreement.Changes in management were observed in 54% of the cases.CONCLUSION CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis. | Carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara Hannah Pitanga Lukashok | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 6 |
| 4 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 5 | Weighted Weak-type Estimates for Multilinear Commutators of Fractional Integrals on Spaces of Homogeneous Type显示文摘我们在同类的类型的空格为部分积分的多线性的整流器获得加权的分布不平等。在这个工作开发的技术包含一些部分最大的功能的行为。在与这些操作员的关系,作为一个主要工具,我们证明一种加权的弱类型围住海角结果,它在自己有趣。 | Osvaldo GOROSITO Gladis PRADOLINI Oscar SALINAS | 2007 | Acta Mathematica Sinica,English Series2007，23，10： | 5 |
| 6 | Extrusion-based 3D food printing-Materials and machines显示文摘To help people with dysphagia increase their food intake,3D printing can be used to improve the visual appeal of pureed diets.In this review,we have looked at the works done to date on extrusion-based 3D food printing with an emphasis on the edible materials(food inks)and machinery(printers)used.We discuss several methods that researchers have employed to modify conventional food materials into printable formulations.In general,additives such as hydrocolloids may modify the rheological properties and texture of a pureed food to confer printability.Some examples of such additives include starch,pectin,gelatin,nanocellulose,alginate,carrageenan etc.In the second part,we have looked at various food printers that have been developed for both academic and commercial purposes.We identified several common advantages and limitations that these printers shared.Moving forward,future research into food printer development should aim to improve on these strengths,eliminate these limitations and incorporate new capabilities. | Cavin Tan Wei Yan Toh Gladys Wong Lin Li | 2018 | International Journal of Bioprinting2018，4，2： | 2 |
| 7 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 8 | 在肝 preconditioning 的最近的进展: 甲状腺荷尔蒙, n-3 长链的多元不堡和丰满的酸和熨斗显示文摘 Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work. | Virginia Fernández Gladys Tapia Luis A Videla | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 9 | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial显示文摘 | Robert J Motzer Bernard Escudier Stéphane Oudard Thomas E Hutson Camillo Porta Sergio Bracarda Viktor Grünwald John A Thompson Robert A Figlin Norbert Hollaender Gladys Urbanowitz William J Berg Andrea Kay David Lebwohl Alain Ravaud | 2008 | The Lancet2008，，9637： | 2 |
| 10 | The isolation from wheat germ oil of an alcohol,alpha-tocopherol,having the properties of vitamin E nutrition显示文摘 | Herbert M E Oliver H E Gladys A E | 1936 | The Journal of Biological Chemistry1936，113，： | 1 |
| 11 | 显示文摘 | Kala R Gladis J M Rao T P | 2004 | Anal Chim Acta2004，518，： | 1 |
| 12 | Quality of life: expanding the scope of clinical significance 显示文摘 | Gladis MM Gosch EA Dishuk NM | 1999 | J Consult Clin Psych1999，，： | 1 |
| 13 | Risk of renal and colonic neo- plasms and spontaneous pneumothorax in the Birt-Hogg-Dube syndrome 显示文摘 | Berton Z Gregory A Gladys G | 2002 | Cancer Epidemiol Biomarkers Prey2002，11，4： | 1 |
| 14 | Tailored materials for preconcentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE) 显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends in Analytical Chemistry2004，23，1： | 1 |
| 15 | Liver NF-KB and AP-1 DNA binding in obese patients 显示文摘 | Luis AV Gladys T Ram6n R | 2009 | Obesity2009，17，5： | 1 |
| 16 | Von Hippel-Lindau disease:genetic,clinical,and imaging feature显示文摘 | Peter L C Gladys M G Meclellan M W | 1995 | Radiology1995，194，： | 1 |
| 17 | Tailored materials for pre- concentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE) 显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends Anal Chem2004，23，1： | 1 |
| 18 | Worldwide or Territorial Approach for Individual Income Tax, Which is More Prevalent?显示文摘 | Connie Shum Jack Fay Gladie Lui | 2017 | Journal of Modern Accounting and Auditing2017，13，4： | 1 |
| 19 | Dilute-acid hydrolysis for fermentation of the Bolivian straw material Paja Brava显示文摘 | Gladys Sanchez Pilcher L Christian Reslander | 2004 | Bioresour Technol2004，93，3： | 1 |
| 20 | Tailored materials for preconcentration or separation of metals by ion-imprinted polymers for solid-phase extraction (IIP-SPE)显示文摘 | Rao T P Daniel S Gladis J M | 2004 | Trends Anal Chem2004，23，1： | 1 |
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