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| 1 | Quality of life in patients with minimal hepatic encephalopathy显示文摘Minimal hepatic encephalopathy(MHE) represents the mildest type of hepatic encephalopathy(HE). This condition alters the performance of psychometric tests by impairing attention, working memory, psychomotor speed, and visuospatial ability, as well as electrophysiological and other functional brain measures. MHE is a frequent complication of liver disease, affecting up to 80% of tested patients, depending of the diagnostic tools used for the diagnosis. MHE is related to falls, to an impairment in fitness to drive and the development of overt HE, MHE severely affects the lives of patients and caregivers by altering their quality of life(QoL) and their socioeconomic status. MHE is detected in clinically asymptomatic patients through appropriate psychometric tests and neurophysiological methods which highlight neuropsychological alterations such as video-spatial orientation deficits, attention disorders, memory, reaction times, electroencephalogram slowing, prolongation of latency evoked cognitive potentials and reduction in the critical flicker frequency. Several treatments have been proposed for MHE treatment such as non-absorbable disaccharides, poorly absorbable antibiotics such rifaximin, probiotics and branched chain amino acids. However, because of the multiple diagnosis methods, the various endpoints of treatment trials and the variety of agents used in trials, to date the treatment of MHE is not routinely recommended apart from on a case-by-case basis. Aim of this review is analyze the burden of MHE on QoL of patients and provide a brief summary of therapeutic approaches. | Lorenzo Ridola Silvia Nardelli Stefania Gioia Oliviero Riggio | 2018 | World Journal of Gastroenterology2018，24，48： | 14 |
| 2 | Acupuncture accelerates recovery after general anesthesia: a prospective randomized controlled trial显示文摘BACKGROUND: Acupuncture anesthesia was created in the 1950's in China and continues to be used there today during most major surgeries. It is widely used in China for such complex operations as brain, heart, and abdominal surgery. It is popular in China because it is economical, practical, and beneficial to the patients. With acupuncture anesthesia there is less bleeding during surgery and there is also quicker post-operative recovery.OBJECTIVE: This randomized prospective study aims at comparing the effect of two acupoints(Yongquan, KI1 and Renzhong, DU26) with sham acupuncture and no acupuncture on the time to recovery of consciousness after general anesthesia by means of the Bispectral Index monitor(BIS).DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a prospective randomized controlled study. We randomly assigned 50 patients to 5 groups during recovery from surgical anesthesia. Four groups had acupuncture on KI1(group A), DU26(groups B), both KI1 and DU26(group C), and sham points(group D), and one had no acupuncture(group E).MAIN OUTCOME MEASURES: Bispectral Index(BIS), time to spontaneous eye opening, time to tracheal extubation, and time to following commands were measured as the main outcome measures.RESULTS: Time to spontaneous eye opening differed among groups(P=0.002), as well as time to tracheal extubation(P<0.000 1) and time to following commands(P=0.000 6). BIS values differed significantly among groups both 5 and 10 min after the end of anesthesia(P<0.000 1 and P=0.000 4,respectively). BIS values of groups D and E were lower than those of the other groups and those of group C were higher. The same pattern was observed also 15 and 30 min after the end of anesthesia, although the difference among groups was not significant at these time points(P=0.164 and P=0.104, respectively).CONCLUSION: Acupuncture on DU26 and KI1 accelerates recovery of consciousness after general anesthesia. Moreover, a possible synergistic effect of DU26 and KI1 is suggested. This issue may play a role in the optimization of operating room management and raise interest about the usefulness of acupuncture on unconsciousness states of different nature. | Marco Gemma Elisa Nicelli Luigi Gioia Elena Moizo Luigi Beretta Maria Rosa Calvi | 2015 | Journal of Integrative Medicine2015，13，2： | 13 |
| 3 | Spontaneous porto-systemic shunts in liver cirrhosis:Clinical and therapeutical aspects显示文摘Spontaneous porto-systemic shunts(SPSS)are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates,probably as a consequence of worsening portal hypertension,but without achieving an effective protection against cirrhosis'complications.Several types of SPSS have been described in the literature,each one associated with different clinical manifestations.In particular,recurrent or persistent hepatic encephalopathy is more frequent in patients with splenorenal shunt,while the presence of gastric varices and consequently the incidence of variceal bleeding is more common in gastrorenal shunt.In the advanced stage,the presence of large SPSS can lead to the so called“portosystemic shunt syndrome”,characterized by a progressive deterioration of hepatic function,hepatic encephalopathy and,sometimes,portal vein thrombosis.The detection of SPSS in patients with liver cirrhosis is recommended in order to prevent or treat recurrent hepatic encephalopathy or variceal bleeding. | Silvia Nardelli Oliviero Riggio Stefania Gioia Marta Puzzono Giuseppe Pelle Lorenzo Ridola | 2020 | World Journal of Gastroenterology2020，26，15： | 11 |
| 4 | Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer显示文摘AIM To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy(PD)in a single Institution.METHODS Between January 2000 and December 2012,151patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our Institution.Patients were divided into two groups:patients with negative PALNs(PALNs-),and patients with metastatic PALNs(PALNs+).Pathologic factors,including stage,nodal status,number of positive nodes and lymph node ratio,invasion of para-aortic nodes,tumor’s grading,and radicality of resection were studied by univariate and multivariate analysis.Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test:significance was considered as P<0.05.RESULTS A total of 107 patients(74%)had nodal metastases.Median number of pathologically assessed lymph nodes was 26(range 14-63).Twenty-five patients(16.5%) had para-aortic lymph node involvement.Thirty-three patients(23%)underwent R1 pancreatic resection.Onehundred forty-one patients recurred and died for tumor recurrence,one is alive with recurrence,and 9 are alive and free of disease.Overall survival was significantly influenced by grading(P=0.0001),radicality of resection(P=0.001),stage(P=0.03),lymph node status(P=0.04),para-aortic nodes metastases(P=0.02).Multivariate analysis showed that grading was an independent prognostic factor for overall survival(P=0.0001),while grading(P=0.0001)and radicality of resection(P=0.01)were prognostic parameters for disease-free survival.Number of metastatic nodes,node ratio,and para-aortic nodes involvement were not independent predictors of disease-free and overall survival.CONCLUSION In this experience,lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis,but they were not independent prognostic factors. | Cosimo Sperti Mario Gruppo Stella Blandamura Michele Valmasoni Gioia Pozza Nicola Passuello Valentina Beltrame Lucia Moletta | 2017 | World Journal of Gastroenterology2017，23，24： | 5 |
| 5 | Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy显示文摘Minimal hepatic encephalopathy (MHE) represents the mildest type of hepatic encephalopathy (HE). MHE is considered as a preclinical stage of HE and is part of a wide spectrum of typical neurocognitive alterations characteristic of patients with liver cirrhosis, particularly involving the areas of attention, alertness, response inhibition, and executive functions. MHE can be detected by testing the patients’ psychometric performance, attention, working memory, psychomotor speed, and visuospatial ability, as well as by means of electrophysiological and other functional brain measures. MHE is very frequent, affecting from 20% up to 80% of patients tested, depending of the diagnostic tools used. Although subclinical, MHE is considered to be clinically relevant. In fact, MHE has been related to the patients’ falls, fitness to drive, and working ability. As a consequence, MHE affects the patients and caregivers lives by altering their quality of life and even their socioeconomic status. Recently sarcopenia, a very common condition in patients with advanced liver disease, has been shown to be strictly related to both minimal and overt HE. Aim of this review is to summarize the most recently published evidences about the emerging relationship between sarcopenia and cognitive impairment in cirrhotic patients and provide suggestions for future research. | Silvia Nardelli Stefania Gioia Jessica Faccioli Oliviero Riggio Lorenzo Ridola | 2019 | World Journal of Gastroenterology2019，25，35： | 4 |
| 6 | Cyclodextrin effects on the ex-situ bioremediation of a chronically polychlorobiphenyl-contaminated soil显示文摘 | Fava F Di Gioia D Marchetti L | 1998 | Biotechnology and Bioengineering1998，58，4： | 2 |
| 7 | Organizational Identity Formation and Change显示文摘 | DennisA. Gioia ShubhaD. Patvardhan AimeeL. Hamilton KevinG. Corley | 2013 | The Academy of Management Annals2013，，1： | 2 |
| 8 | Pancreatic resection in very elderly patients:A critical analysis of existing evidence显示文摘The aging of the population results in a rise of number of elderly patients(aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these 'frail' patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients. | Cosimo Sperti Lucia Moletta Gioia Pozza | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 2 |
| 9 | Accumulation of heavy metals from contaminated soil to plants and evaluation of soil remediation by vermiculite显示文摘 | Mery Malandrino Ornella Abollino Sandro Buoso Agnese Giacomino Carmela La Gioia Edoardo Mentasti | 2010 | Chemosphere2010，，2： | 2 |
| 10 | 心脏猝死的治疗──药物与埋藏式心脏复律除颤器显示文摘1前言1.1心脏猝死问题的重要性据美国心脏病学会(AHA)估计,5800万美国人患有一种或多种心脏疾病。1994年大约95万美国人死于心血管疾病,占该年因各种原因死亡人数的42%。相比较,该年美国因癌症死亡54万人、意外死亡9万人,因艾滋病死亡4.2... | Gioia,T 胡大一 | 1999 | 中国心脏起搏与心电生理杂志1999，13，1： | 2 |
| 11 | Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis?显示文摘Porto sinusoidal vascular liver disease (PSVD) and portal vein thrombosis (PVT) are distinct vascular liver diseases characterized, respectively, by an intrahepatic and a prehepatic obstacle to the flow in the liver portal system. PVT may also occur as a complication of the natural history of PSVD, especially if a prothrombotic condition coexists. In other cases, it is associated to local and systemic pro-thrombotic conditions, even if its cause remains unknown in up to 25% despite an active search. In our opinion, the presence of PSVD should be suspected in patients with PVT especially in those with PVT “sine causa” and the active search of this condition should be included in their diagnostic work-out. However, sometimes the diagnosis of pre-existing PSVD is very hard. Biopsy cannot be fully discriminant as similar histological data have been described in both conditions. Liver stiffness may help as it has been shown to be higher in PSVD than in “pure” PVT, due to the presence of sclerosis in the portal venous radicles observable in PSVD patients. Nevertheless, comparing liver stiffness between PVT and PSVD has until now been restricted to very limited series of patients. In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors. | Stefania Gioia Silvia Nardelli Lorenzo Ridola Giulia d’Amati Oliviero Riggio | 2019 | World Journal of Hepatology2019，11，8： | 2 |
| 12 | Association of chronic hepatitis C with recurrent brief depression显示文摘 | Mauro G. Carta Jules Angst Maria Francesca Moro Gioia Mura Maria Carolina Hardoy Cinzia Balestrieri Luchino Chessa Giancarlo Serra Maria Eliana Lai Patrizia Farci | 2012 | Journal of Affective Disorders2012，，2： | 2 |
| 13 | Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes显示文摘 | Diego Sbardella Giovanni Francesco Fasciglione Magda Gioia Chiara Ciaccio Grazia Raffaella Tundo Stefano Marini Massimo Coletta | 2011 | Molecular Aspects of Medicine2011，，2： | 2 |
| 14 | Standard laparoscopic versus single-incision laparoscopic colectomy for cancer: early results of a randomized prospective study显示文摘 | Cristiano G. Huscher Andrea Mingoli Giovanna Sgarzini Andrea Mereu Barbara Binda Gioia Brachini Silvia Trombetta | 2012 | The American Journal of Surgery2012，，1： | 2 |
| 15 | Activated Vgamma9Vdelta2Tcells trigger granulocyte functions via MCP-2release显示文摘 | Agrati C Cimini E Sacchi A Bordoni V Gioia C Casetti R Turchi F Tripodi M Martini F | 2009 | J Immunol2009，182，1： | 1 |
| 16 | Association of ABCB1/MDRI and OPRM1 gene polymorphisms with morphine pain relief 显示文摘 | Campa D Gioia A Tomei A | 2008 | Clin Pharmacol Ther2008，83，4： | 1 |
| 17 | Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032显示文摘 | Gioia J Yerrapragada S Qin X | 2007 | PLoS One2007，2，9： | 1 |
| 18 | Effect s of IFI16 overexpression on the growth and doxorubicin sensitivity of head and neck squamous cell carcinoma-derived cell lines显示文摘 | De Andrea M Gioia D Mondini M | | 0，，： | 1 |
| 19 | Ischemia in intracerebral hemorrhage is associated with leukoaraiosis and hematoma volume,not blood pressure reduction显示文摘 | Gioia LC Kate M Choi V | 2015 | Stroke2015，46，6： | 1 |
| 20 | Sensemaking and sensegiving in strategic change initiation 显示文摘 | Gioia Dennis A & Chittipeddi kumar | 1991 | Strategic Management Journal1991，，12： | 1 |
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