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| 1 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 2 | Clay swelling and formation permeability reductions induced by a nonionic surfactant 显示文摘 | Gardner K H Arias M S | 2000 | Environ Sci Technol2000，34，1： | 2 |
| 3 | SOFC technology development at Rolls-Royce显示文摘 | Gardner F J Day M J Brandon N P | 2000 | J Power Sources2000，86，： | 2 |
| 4 | Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis显示文摘AIM:To identify and characterize drosophila mothers against decapentaplegic(SMAD)3-dependent changes in immune cell populations following infection with Helicobacter hepaticus(H.hepaticus).METHODS:SMAD3 -/-(n=19)and colitis-resistant SMAD3+/-(n=24)mice(8-10 wk of age)were in-fected with H.hepaticus and changes in immune cell populations[T lymphocytes,natural killer(NK)cells,T regulatory cells]were measured in the spleen and mesenteric lymph nodes(MsLNs)at 0 d,3 d,7 d and 28 d post-infection using flow cytometry.Genotypedependent changes in T lymphocytes and granzyme B+ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry.RESULTS:As previously observed,SMAD3 -/-,but not SMAD3+/-mice,developed colitis,peaking at 4 wk post-infection.No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point.However,CD4+and CD8+/ CD62Llo cells,an effector T lymphocyte population,as well as NK cells(NKp46/DX5+)were significantly higher in the MsLNs of SMAD3-/-mice at 7 d and 28 d post-infection.In the colon,a higher number of CD3+cells were present in SMAD3-/-compared to SMAD3+/-mice at baseline,which did not significantly change during infection.However,the number of granzyme B+cells,a marker of cytolytic lymphocytes,significantly increased in SMAD3-/-mice 28 d post-infection compared to both SMAD3+/-mice and to baseline values.This was consistent with more severe colitis development in these animals.CONCLUSION:Data suggest that defects in SMAD3 signaling increase susceptibility to H.hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphocytes. | Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton | 2012 | World Journal of Gastroenterology2012，18，13： | 2 |
| 5 | Neutral models for the analysis of broad-scale landscape pattern显示文摘 | Gardner R H Mime B T Turner M G | 1987 | Landscape Ecology1987，1，1： | 2 |
| 6 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 7 | Clay swelling and formation permeability reductions induced by a nonionic surfactant显示文摘 | GARDNER K H ARIAS M S | 2000 | Environ Sci Technol2000，34，： | 1 |
| 8 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 9 | Comparative gene analysis of Biomphalaria glabrata hemocytes pre- and post-exposure to miracidia of Schistosoma mansoni 显示文摘 | Raghavan N Miller AN Gardner M | 2003 | Mol Biochem Parasito12003，126，2： | 1 |
| 10 | Liver from bone marrow in humans显示文摘 | Nimmakayalu M Gardner R | 2000 | Hepatology2000，32，： | 1 |
| 11 | The relationship between HR practices and firm performance : Examining causal order 显示文摘 | Wright P M Gardner T M Moynihan L M | 2005 | Personnel Psychology2005，58，2： | 1 |
| 12 | Prediction of soft-tissue injuries in Schatzker II tibial plateau fractures based on measurements of plain radiographs 显示文摘 | Gardner M J Yaeaubian S Geller D | 2006 | Trauma2006，2，： | 1 |
| 13 | Steady-state planar ablative flow显示文摘 | Manheimer W M Colombant D G Gardner J H | 1982 | PhysFluids1982，25，： | 1 |
| 14 | Evaluation and treatment of dural tears in lumbar spine surgery: a review 显示文摘 | Bosacco S J Gardner M J Guille Jr | 2001 | Clin Orthop Relat Res2001，389，： | 1 |
| 15 | The fantastic combinations of John Conway's new solitaire game of life 显示文摘 | Gardner M | 1970 | Scientific American1970，223，： | 1 |
| 16 | Pathogenicity and cultural characters of the apple sooty-blotch fungus显示文摘 | Baines R C Gardner M W | 1932 | Phytopathology1932，22，： | 1 |
| 17 | Hemoglobins dioxygenate nitric oxide with high fidelity显示文摘 | Gardner P R Gardner A M Brashear W T | 2006 | J Inorg Biochem2006，100，4： | 1 |
| 18 | Conservation reserve program effects on soil quality indicators显示文摘 | Karlen D L Rosek M J Gardner J C | 1999 | Journal of Soil and Water Conservation1999，54，1： | 1 |
| 19 | Fixation of posterior malleolar fractures provides greater syndesmotic stability显示文摘 | Gardner M J Brodsky A Briggs SM | 2006 | Clin Orthop Relat Res2006，447，： | 1 |
| 20 | Chondrogenesis of mesenchymal stem cells for cartilage tissue engineering显示文摘 | Gardner OF Archer CW Alini M | | 0，，01： | 1 |
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