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| 1 | Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis显示文摘Crohn's disease and ulcerative colitis evolve with a relapsing and remitting course.Determination of inflammatory state is crucial for the assessment of disease activity and for tailoring therapy.However,no simple diagnostic test for monitoring intestinal inflammation is available.Noninvasive markers give only indirect assessments of disease activity.Histopathological or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine use.Imaging procedures are not applicable for ulcerative colitis.The usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal findings.Until now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE.Due to this,clinical activity indices are still commonly used for both diseases. | Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes Andrade Aloísio Sales da Cunha | 2012 | World Journal of Gastroenterology2012，18，9： | 23 |
| 2 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 3 | Stable two-sided matching of slot allocation in airport collaborative decision making by top trading cycles mechanism显示文摘The problem of capacity shortage in some airports needs to be dealt with sustainable solutions including a more efficient use of the existing runway slots at the airports. The Collaborative Decision Making(CDM) is an important approach applied to Air Traffic Management(ATM)to achieve this efficient use of the slots allocation. Using the Matching approach for two-sided markets of Game theory, the Top Trading Cycle CDM(TTC-CDM) algorithm developed in this research is an extension of the CDM approach aggregating the Ground Delay Program(GDP)of the air sector. The paper compared the developed TTC-CDM model to the existing models such as the conventional Compression algorithm in CDM, the Trade Cycle algorithm and the Deferred Acceptance CDM(DA-CDM) model to evaluate the performance of the proposed model. Through a case study, the results show the effective application of TTC-CDM model to slot allocation in ATM and also presents the advantage of considering the preferences of airport managers beside ATC controllers and airlines in the decision processing. | Marcio Augusto DA SILVA SOUZA Weigang LI Reinaldo Crispiniano GARCIA | 2018 | Chinese Journal of Aeronautics2018，31，3： | 5 |
| 4 | Phosphomonoester Phosphoethanolamine Induces Apoptosis in Human Chronic Myeloid Leukemia Cells显示文摘Background:Leukemia is a type of cancer that starts in the blood or blood-forming tissues.It results from the clonal proliferation of hematopoietic cells in the bone marrow and/or lymphoid tissues,which subsequently reach the peripheral circulation and can infiltrate other systems.There are many different kinds of leukemia,and treatments are different for each one.Chronic leukemia is with a slower growing than acute leukemia but could be just as life-threatening.Phospholipids are antitumor analogs,such as synthetic phosphoethanolamine,which is a phosphorylated compound capable of controlling cellular proliferation and inducing apoptosis in several types of tumor cells.Methods:K562 and K562-Lucena(MDR+)human chronic myeloid leukemia cells were treated with synthetic phosphoethanolamine(Pho-s).The viability was evaluated by sulforhodamine B(SRB)assay and cell cycle phases,apoptosis,markers expression,and mitochondrial potential were assessed by flow cytometry.Results:Tumor cells formed clusters in suspension and decreased significantly viability.The concentrations for IC50%were obtained.Pho-s treated were 43.1 mM(K562)and 145.9 mM(K562-Lucena MDR+)in a period of 24 hours.Pho-s induced changes in the distribution of cell population phases of cell cycle which showed an increase in fragmented DNA and increased markers expression envolved apoptosis pathways a decrease in the G1/G0 phase.Discussion:Treatment of K562 and K562-Lucena(MDR+)chronic myeloid leukemia cells with Pho-s showed dose and time dependent cytotoxic effects.This cytotoxicity induced a decrease in proliferative capacity,mitochondrial electrical potential,and consequently release of cytochrome C;inhibition of Bcl-2 family protein expression,increase in pro-apoptotic family members Bad and Bax,dependent on p53 expression.Conclusion:This study presented a significant therapeutic potential of Phos-s in this type of leukemia through the apoptotic effects on tumor cells independently of the molecular resistance profile(MDR+). | Thais de Oliveira Conceicao Manuela Garcia Laveli da Silva Durvanei Augusto Maria | 2019 | Journal of Pharmacy and Pharmacology2019，7，7： | 3 |
| 5 | Meclizine Chloridrate and Methyl-β-Cyclodextrin Associated with Monophosphoester Synthetic Phosphoethanolamine Modulating Proliferative Potential in Triple-Negative Breast Cancer Cells显示文摘Synthetic phosphoethanolamine(Pho-s)is a monophosphoester ester with anti-inflammatory and pro-apoptotic properties.Meclizine chloridrate(MC)is a histamine H1 receptor blocker that is also able to inhibit cellular respiration.However,MC does not inhibit cellular respiration in isolated mitochondria such as antimycin and rotenone.Methyl-β-cyclodextrin(MβCD)belongs to theβ-cyclodextrin family,which is capable of removing cholesterol from the plasma membrane.The aim of this study was to evaluate the proliferative effects of meclizine chloridrate and methyl-β-cyclodextrin compounds associated with synthetic phosphoethanolamine in a triple-negative human breast tumor line,MDA-MB-231 Cell viability of the tumor line and normal cells FN1 was evaluated by MTT colorimetric test;the production of free radicals was determined by lipoperoxidation(LPO)test;and the percentage of cell cycle phases and proliferative index was evaluated by flow cytometry.Cell viability demonstrated a significant decrease with the treatments of MβCD,MC and Pho-s associated with MC.The production of free radicals decreases significantly in all treatments.In addition,a significant increase of DNA fragment and decrease in G0/G1 cell cycle phase were observed in cellular percentage with concentrations of 20 and 30 mM of Pho-s in association with MC and MβCD,respectively. | Manuela Garcia Laveli da Silva Luciana Bastianelli Knop Durvanei Augusto Maria | 2019 | Journal of Pharmacy and Pharmacology2019，7，7： | 2 |
| 6 | Parenteral anticoagulants:Antithrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians evidence-based clinical practice guidelines显示文摘 | Garcia DA Baglin TP Weitz JI | 2012 | Chest2012，141，2： | 1 |
| 7 | The Antioxidant Activity of Coumarins and Flavonoids显示文摘 | Guilherme Borges Bubols Damiana da Rocha Vianna Alexander Medina-Remon Gilsane von Poser Rosa Maria Lamuela-Raventos Vera Lucia Eifler-Lima Solange Cristina Garcia | 2013 | Mini-Reviews in Medicinal Chemistry2013，，3： | 1 |
| 8 | Depressed mood and poor quality of life in male patients with chronic renal failure undergoing hemodialysis显示文摘 | Garcia TW Veiga JP da Motta LD | 2010 | Rev Bras Psiquiatr2010，32，4： | 1 |
| 9 | Preconditioning by sevoura - ne decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery:a doubleblinded,placebo - controlled,multicenter study 显示文摘 | da Silva R Garcia C | 2003 | Anesthesiology2003，98，： | 1 |
| 10 | Insulin sensitivity,glucose effectiveness,and insulin secretion in nondiabetic offspring of patients with non-insulin-dependent diabetes mellitus:A cross-sectional study 显示文摘 | Araujo D Garcia DA Cabezas J | 1999 | Metabolism1999，48，： | 1 |
| 11 | Planning with graded nondeterministic actions: A possibilistic approach 显示文摘 | Costa Pereira C da Garcia F Lang J | 1997 | International Journal of Intelligent Systems1997，12，1112： | 1 |
| 12 | Delay- dependent anti-windup strategy for linear systems with saturat- ing inputs and delayed outputs显示文摘 | Tarbouriech S Gomes Da Silva Jr J M Garcia G | 2004 | International Journal of Ro- bust and Nonlinear Control2004，14，7： | 1 |
| 13 | Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors显示文摘 | Kaatz S Kouides PA Garcia DA | 2012 | Am J Hematol2012，87，1： | 1 |
| 14 | Prevention of VTE in no- northopedic surgical patients :Antithrombotic Therapy and Pre- vention of Thrombosis, 9th ed : American College of Chest Physi- cians Evidence-Based Clinical Practice Guidelines显示文摘 | Gould MK Garcia DA Wren SM | 2012 | Chest2012，141，2： | 1 |
| 15 | Prevalence, characteristics, and factors associated with chronic pain with and without neuropathic characteristics in Sao Luis, Brazil 显示文摘 | de Moraes Vieira EB Garcia JB da Silva AA | 2012 | J Pain Symptom Manage2012，44，： | 1 |
| 16 | Impact of smoking status on outcomes of primary coronary intervention for acute myocardial in- farcion-the smoker's paradox revisited显示文摘 | Weisz G Cox DA Garcia E | 2005 | Am Heart J2005，150，2： | 1 |
| 17 | Effects of cardiac resynchronization therapy on overall mortality and mode of death: a meta-analysis of randomized controlled trials显示文摘 | Rivero AM Theuns DA Garcia HM | 2006 | Eur Heart J2006，27，22： | 1 |
| 18 | Continuous Versus Interrupted Suture for Hepatic Artery Anastomosis in Liver Transplantation: Differences in the Incidence of Hepatic Artery Thrombosis显示文摘 | G.R. Coelho A.S. Leitao F.P. Cavalcante I.R.C. Brasil G. Cesar-Borges P.E.G. Costa M.A.P. Barros P.M. Lopes E.H. Nascimento J.I. da Costa C.F. Viana T.D.S. Rocha J.B.M. Vasconcelos J.H.P. Garcia | 2008 | Transplantation Proceedings2008，，10： | 1 |
| 19 | Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines显示文摘 | Gould MK Garcia DA Wren SM | 2012 | Chest2012，141，2： | 1 |
| 20 | sk facm for devdopingepi Mpsy Afterncon Mizures显示文摘 | Garcias DS Nunes ML Da Cam JC | 2004 | Pedia2004，30，4： | 1 |
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