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| 1 | Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model显示文摘Nerve conduit is one of strategies for spine cord injury(SCI)treatment.Recently,studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury site.However,the scaffold by itself was difficult to meet the need of SCI functional recovery.The basic fibroblast growth factor(bFGF)administration significantly promotes functional recovery after organ injuries.Here,using a rat model of T9 hemisected SCI,we aimed at assessing the repair capacity of implantation of collagen scaffold(CS)modified by collagen binding bFGF(CBD-bFGF).The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection SCI.The CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group,when evaluated by the 21-point Basso-Beattie-Bresnahan(BBB)score and footprint analysis.Both hematoxylin and eosin(H&E)and immunohistochemical staining of neurofilament(NF)and glial fibrillary acidic protein(GFAP)demonstrated that fibers were guided to grow through the implants.These findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery. | SHI Qin GAO Wei HAN XingLong ZHU XueSong SUN Jie XIE Fang HOU XiangLin YANG HuiLin DAI JianWu CHEN Liang | 2014 | Science China(Life Sciences)2014，57，2： | 23 |
| 2 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 3 | The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B显示文摘OCT4 is one of the key transcription factors in maintaining the pluripotency and self-renewal of embryonic stem (ES) cells.Human OCT4 can generate two isoforms OCT4A and OCT4B by alternative splicing.OCT4B1 is a recently discovered novel OCT4 spliced variant,which has been considered as a putative marker of stemness.Compared with the OCT4B mRNA,OCT4B1 mRNA is generated by retaining intron 2 as a cryptic exon which contains a TGA stop codon in it.As a result,the protein product of OCT4B1 mRNA could be truncated.Interestingly,we present here that OCT4B1 can indirectly produce the same protein products as OCT4B.We have demonstrated that OCT4B1 mRNA can be spliced into OCT4B mRNA,and encode three protein isoforms.The splicing of OCT4B1 mRNA into OCT4B mRNA can be remarkably inhibited by the mutation of the classical splicing site.Our result suggests that OCT4B mRNA may originate from OCT4B1 mRNA by alternative splicing. | Yuan Gao Xia Wang Jin Han Zhifeng Xiao Bing Chen Guannan Su Jianwu Dai | 2010 | Journal of Genetics and Genomics2010，37，7： | 6 |
| 4 | Seasonal and Interannual Variations of Carbon Exchange over a Rice–Wheat Rotation System on the North China Plain显示文摘Rice–wheat(R–W) rotation systems are ubiquitous in South and East Asia,and play an important role in modulating the carbon cycle and climate. Long-term,continuous flux measurements help in better understanding the seasonal and interannual variation of the carbon budget over R–W rotation systems. In this study,measurements of CO2 fluxes and meteorological variables over an R–W rotation system on the North China Plain from 2007 to 2010 were analyzed. To analyze the abiotic factors regulating Net Ecosystem Exchange(NEE),NEE was partitioned into gross primary production(GPP) and ecosystem respiration. Nighttime NEE or ecosystem respiration was controlled primarily by soil temperature,while daytime NEE was mainly determined by photosythetically active radiation(PAR). The responses of nighttime NEE to soil temperature and daytime NEE to light were closely associated with crop development and photosynthetic activity,respectively. Moreover,the interannual variation in GPP and NEE mainly depended on precipitation and PAR. Overall,NEE was negative on the annual scale and the rotation system behaved as a carbon sink of 982 g C m-2per year over the three years. The winter wheat field took up more CO2 than the rice paddy during the longer growing season,while the daily NEE for wheat and rice were-2.35and-3.96 g C m-2,respectively. After the grain harvest was subtracted from the NEE,the winter wheat field became a moderately strong carbon sink of 251–334 g C m-2per season,whereas the rice paddy switched to a weak carbon sink of107–132 per season. | CHEN Chen LI Dan GAO Zhiqiu Jianwu TANG GUO Xiaofeng WANG Linlin WAN Bingcheng | 2015 | Advances in Atmospheric Sciences2015，32，10： | 6 |
| 5 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 6 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 7 | FEEDBACK LINEARIZATION CONTROL FOR ELECTRONICALLY CONTROLLABLE CLUTCH OF VEHICLE显示文摘An investigation is made to the friction chutch engagement control of automotive AMT systems based on a nonlinear dynamic model with double inputs. According to friction torque transmission characteristics during clutch engagement, an equivalent, fully controllable and linearized model and the feedback linearization control are derived from the original system with nonlinearities via homomorphic transforms. By the resulting mathematical modeling, computer simulations are made both for the original nonlinear and feedback linearized systems with incorporation of ordinary PID controllers to follow ideal vehicle dynamic responses. It has been shown by comparison between the two sets of numerical results that the feedback linearization control designed for the nonlinear system is of fine accuracy and robustness in model tracking behaviors of clutch engagements. | Chen Li Zhang Jianwu Huang Weigang Shanghai Jiaotong University Gao Chunming Shanghai Clutch Factory | 1999 | Chinese Journal of Mechanical Engineering1999，12，4： | 3 |
| 8 | Puerarin accelerates neural regeneration after sciatic nerve injury显示文摘Puerarin is a natural isoflavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puerarin(8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atrophy of the triceps surae on the affected side and promoted the regeneration of nerve fibers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciatic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries. | Minfei Wu Guanjie Zhao Xiaoyu Yang Chuangang Peng Jianwu Zhao Jun Liu Rui Li Zhongli Gao | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 9 | Seasonal Responses of Net Primary Productivity of Vegetation to Phenological Dynamics in the Loess Plateau, China显示文摘With global warming, the great changes in the patterns of plant growth have occurred. The conditions in early spring and late autumn have changed the process of vegetation photosynthesis, which are expected to have a significant impact on net primary productivity(NPP) and affect the global carbon cycle. Currently, the seasonal response characteristics of NPP to phenological changes in dryland ecosystems are still not well defined. This article calibrated and analyzed the normalized difference vegetation index(NDVI)time series of Advanced Very-High-Resolution Radiometer(AVHRR) data from 1982 to 2015 in the Loess Plateau, China. The spatial and temporal distributions of vegetation phenology and NPP in the Loess Plateau under semihumid and semiarid conditions were investigated. The seasonal variation in the NPP response to vegetation phenology under the climate change was also analyzed. The results showed that, different from the northern forest, there was distinct spatial heterogeneity in the effect of climate change on the dynamic change in vegetation growth in the Loess Plateau: 1) an advance of the start of the growing season(SOS) and a delay of the end of the growing season(EOS) significantly increased the NPP in spring and autumn, respectively, in the humid southeast;2) in the arid northwest, the NPP did not significantly increase in spring and autumn but significantly decreased in summer. | HAN Hongzhu BAI Jianjun MA Gao YAN Jianwu WANG Xiaohui TA Zhijie WANG Pengtao | 2022 | Chinese Geographical Science2022，32，2： | 2 |
| 10 | Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair显示文摘Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neovascularization and neurogenesis, and potential signaling involved therein, are unclear. Here, we established a primary spinal cord-derived MECs (SCMECs) isolation with high cell yield and purity to describe the differences with brain-derived MECs (BMECs) and their therapeutic effects on SCI. Transcriptomics and proteomics revealed differentially expressed genes and proteins in SCMECs were involved in angiogenesis, immunity, metabolism, and cell adhesion molecular signaling was the only signaling pathway enriched of top 10 in differentially expressed genes and proteins KEGG analysis. SCMECs and BMECs could be induced angiogenesis by different stiffness stimulation of PEG hydrogels with elastic modulus 50-1650 Pa for SCMECs and 50-300 Pa for BMECs, respectively. Moreover, SCMECs and BMECs promoted spinal cord or brain-derived NSC (SNSC/BNSC) proliferation, migration, and differentiation at different levels. At certain dose, SCMECs in combination with the NeuroRegen scaffold, showed higher effectiveness in the promotion of vascular reconstruction. The potential underlying mechanism of this phenomenon may through VEGF/AKT/eNOS- signaling pathway, and consequently accelerated neuronal regeneration and functional recovery of SCI rats compared to BMECs. Our findings suggested a promising role of SCMECs in restoring vascularization and neural regeneration. | Zhifeng You Xu Gao Xinyi Kang Wen Yang Tiandi Xiong Yue Li Feng Wei Yan Zhuang Ting Zhang Yifu Sun He Shen Jianwu Dai | 2023 | Bioactive Materials2023，，11： | 2 |
| 11 | Stem cell research is coming of age in China显示文摘In recent years,stem cell research has become one of the most exciting and promising biological fields,which offers great opportunities for curing many diseases that are currently recalcitrant to traditional clinical approaches. | Dr. Jianwu Dai Dr. Shaorong Gao | 2010 | Journal of Genetics and Genomics2010，37，7： | 2 |
| 12 | Triflic Acid-Functionalized Silica-Coated Magnetic Nanoparticles as a Magnetically Separable Catalyst for Synthesis of gem-Dihydroperoxides显示文摘 | Liu Yonghui Deng Jia Gao Jianwu | | 0，，3： | 1 |
| 13 | Chromato- graphic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang de- coction and their characterization显示文摘 | Zhou Jianwu Gao Guanzhen Chu Qiuping | 2014 | J Ethnopharmacol2014，151，3： | 1 |
| 14 | NbCl5:An Efficient Catalyst for One-pot Synthesis of α-aminophosphonates Under Solvent-free Conditions显示文摘 | HOU Juntao GAO Jianwu ZHANG Zhanhui | 2011 | Appl Organomet Chem2011，25，1： | 1 |
| 15 | The Risk Factors and Environm ental Risk Prediction during the Production of Yellow Phosphorus显示文摘Phosphorus is an important chemical raw material of economy. There are several risk factors in the entire production process of yellow phosphorus. The health of the production staff was greatly endangered by the toxic and harmful substances. The generation of risk factors was analyzed during the yellow phosphorus production and its harm was discussed,and several toxic and harmful substances were tested for a number of phosphorus manufacturing enterprises. The environmental risks of P2O5 in phosphorus pollution sources were scientifically predicted on the first time. | Gao Ye Dong Guoli Zhang Jie Gao Huaping Hu Xuewei Shi Jianwu | 2014 | Meteorological and Environmental Research2014，5，10： | 1 |
| 16 | Triflic Acid-functionalized Silica-coated Magnetic Nanoparticles a Magneti- cally Separable Catalyst for Synthesis of Gem-dihydroperoxides显示文摘 | LIU Yonghui DENG Jia GAO Jianwu | 2012 | Adv Synth Catal2012，354，23： | 1 |
| 17 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 18 | Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts显示文摘OCT4 and NANOG are two important tran-scription factors for maintaining the pluripotency and self-renewal abilities of embryonic stem(ES)cells.Meanwhile they play key roles in the induced pluripotent stem(iPS)cells.In this study,recombinant transcript factors TAT-NANOG and TAT-OCT4,which contained a fused powerful protein transduction domain(PTD)TAT from human immunodeficiency virus(HIV),were produced.Each fusion protein could be transported into human adultfibroblasts(HAF)successfully and activated the endogen-ous transcription of both nanog and oct4.Our study revealed the inter-regulation and autoregulation abilities of solo oct4 or nanog in the process of iPS cell reprogram-ming.Meanwhile the transduction of TAT-NANOG could accelerate the growth rate of HAF cells,and the key cell cycle regulator cdc25a was up-regulated.Thus cdc25a may be involved in the regulation of cell growth by NANOG.In addition,the TAT fusion protein technology provided a novel way to improve cell growth that is more controllable and safer. | Jiani CAO Zhifeng XIAO Bing CHEN Yuan GAO Chunying SHI Jinhuan WANG Jianwu DAI | 2010 | Frontiers in Biology2010，5，5： | 0 |
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