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| 1 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 2 | Upper tail probabilities of integrated Brownian motions显示文摘We obtain new upper tail probabilities of m-times integrated Brownian motions under the uniform norm and the Lp norm. For the uniform norm, Talagrand's approach is used, while for the Lp norm, Zolotare's approach together with suitable metric entropy and the associated small ball probabilities are used. This proposed method leads to an interesting and concrete connection between small ball probabilities and upper tail probabilities(large ball probabilities) for general Gaussian random variables in Banach spaces. As applications,explicit bounds are given for the largest eigenvalue of the covariance operator, and appropriate limiting behaviors of the Laplace transforms of m-times integrated Brownian motions are presented as well. | GAO FuChang YANG XiangFeng | 2015 | Science China Mathematics2015，58，5： | 1 |
| 3 | Entropy estimate for high-dimensional monotonic functions显示文摘 | Fuchang Gao and Jon A Wellner | 2006 | Journal of Multivariate Analysis In Press Corrected Proof Available online 30 October 20062006，33，10： | 1 |
| 4 | Implementing the Nelder-Mead simplex algorithm with adaptive parameters 显示文摘 | Fuchang Gao Lixing Han | 2012 | Computa- tional Optimization and Applications2012，，7： | 1 |
| 5 | Entropy estimate for high-dimensional monotonic functions显示文摘 | Gao Fuchang Wellner Jon A | 2006 | Journal of Multivariate Analysis2006，33，10： | 1 |
| 6 | Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits显示文摘This study was conducted to evaluate the effect of pyridoxine on the development of hair follicles in Rex rabbits and the underlying molecular mechanism.Two hundred 3-month-old Rex rabbits were randomly divided into 5 groups and fed diets supplemented with 0,5,10,20,or 40 mg/kg pyridoxine.The hair follicle density on the dorsal skin and the gene and protein expression levels of components of the phosphoinositide 3-kinase(PI3 K)/protein kinase B(PKB or Akt),Wnt,Notch and bone morphogenetic protein(BMP)signalling pathways were measured.In addition,free hair follicles were isolated from Rex rabbits and cultured with pyridoxine in vitro to measure hair shaft growth.Furthermore,dermal papilla cells(DPC)were isolated from the skin of Rex rabbits and cultured with pyridoxine in vitro to measure the gene and protein expression levels of components of the PI3 K/Akt,Wnt,Notch and BMP signalling pathways.The results showed that the addition of dietary pyridoxine significantly increased the total follicle density,secondary follicle density,and secondary-to-primary ratio(S/P,P<0.05),that the growth ratio of hair stems was promoted by pyridoxine in basic culture medium,and that the growth length of tentacle hair follicles cultured in the pyridoxine group was longer than that in the control group(P<0.05).In addition,pyridoxine changed the DPC cycle progression and promoted cell proliferation,and appropriate concentrations of pyridoxine(10 and 20μmol/L)significantly inhibited cell apoptosis(P<0.05).Pyridoxine significantly affected the gene expression of components of the PI3 K/Akt,Wnt and Notch signalling pathways in the skin and DPC of Rex rabbits(P<0.05),increased the levels of phosphorylated catenin beta 1(CTNNB1)and Akt,and decreased the level of phosphorylated glycogen synthase kinase 3 beta(GSK-3β)(P<0.05).Therefore,the molecular mechanism by which pyridoxine promotes hair follicle density in Rex rabbits probably occurs through activation of the PI3 K/Akt,Wnt and Notch signalling pathways,prolonging hair follicle growth and delaying the onset of telogen. | Gongyan Liu Guangmin Cheng Yongcui Zhang Shuxia Gao Haitao Sun Liya Bai Shu Li Yanli Zhu Chunyang Wang Fuchang Li | 2021 | Animal Nutrition2021，，4： | 1 |
| 7 | Entropy estimate for high-dimensional Monotonic Functions显示文摘 | Fuchang Gao and Jon A Wellner | 2006 | Journal of Multivariate Analysis In Press Corrected Proof2006，30，： | 1 |
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