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| 1 | Electronic Skin from High-Throughput Fabrication of Intrinsically Stretchable Lead Zirconate Titanate Elastomer显示文摘Electronic skin made of thin,soft,stretchable devices that can mimic the human skin and reconstruct the tactile sensation and perception offers great opportunities for prosthesis sensing,robotics controlling,and human-machine interfaces.Advanced materials and mechanics engineering of thin film devices has proven to be an efficient route to enable and enhance flexibility and stretchability of various electronic skins;however,the density of devices is still low owing to the limitation in existing fabrication techniques.Here,we report a high-throughput one-step process to fabricate large tactile sensing arrays with a sensor density of 25 sensors/cm^(2) for electronic skin,where the sensors are based on intrinsically stretchable piezoelectric lead zirconate titanate(PZT)elastomer.The PZT elastomer sensor arrays with great uniformity and passive-driven manner enable highresolution tactile sensing,simplify the data acquisition process,and lower the manufacturing cost.The high-throughput fabrication process provides a general platform for integrating intrinsically stretchable materials into large area,high device density soft electronics for the next-generation electronic skin. | Yiming Liu Huanxi Zheng Ling Zhao Shiyuan Liu Kuanming Yao Dengfeng Li Chunki Yiu Shenghan Gao Raudel Avila Pakpong Chirarattananon Lingqian Chang Zuankai Wang Xian Huang Zhaoqian Xie Zhengbao Yang Xinge Yu | 2020 | Research2020，，1： | 11 |
| 2 | Interactions between wind and water erosion change sediment yield and particle distribution under simulated conditions显示文摘Wind and water erosion are among the most important causes of soil loss, and understanding their interactions is important for estimating soil quality and environmental impacts in regions where both types of erosion occur. We used a wind tunnel and simulated rainfall to study sediment yield, particle-size distribution and the fractal dimension of the sediment particles under wind and water erosion. The experiment was conducted with wind erosion firstly and water erosion thereafter, under three wind speeds(0, 11 and 14 m/s) and three rainfall intensities(60, 80 and 100 mm/h). The results showed that the sediment yield was positively correlated with wind speed and rainfall intensity(P<0.01). Wind erosion exacerbated water erosion and increased sediment yield by 7.25%–38.97% relative to the absence of wind erosion. Wind erosion changed the sediment particle distribution by influencing the micro-topography of the sloping land surface. The clay, silt and sand contents of eroded sediment were also positively correlated with wind speed and rainfall intensity(P<0.01). Wind erosion increased clay and silt contents by 0.35%–19.60% and 5.80%–21.10%, respectively, and decreased sand content by 2.40%–8.33%, relative to the absence of wind erosion. The effect of wind erosion on sediment particles became weaker with increasing rainfall intensities, which was consistent with the variation in sediment yield. However, particle-size distribution was not closely correlated with sediment yield(P>0.05). The fractal dimension of the sediment particles was significantly different under different intensities of water erosion(P<0.05), but no significant difference was found under wind and water erosion. The findings reported in this study implicated that both water and wind erosion should be controlled to reduce their intensifying effects, and the controlling of wind erosion could significantly reduce water erosion in this wind-water erosion crisscross region. | TUO Dengfeng XU Mingxiang ZHAO Yunge GAO Liqian | 2015 | Journal of Arid Land2015，7，5： | 8 |
| 3 | microRNAs in heart failure显示文摘Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases.An increasing body of evidence indicates an important role for microRNAs (miRNAs)in the pathogenesis and progression of heart failure.miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides (nt) (a few less than 20 nt) to regulate target gene expression at the post-transcriptional level.Mature miRNAs are formed after shearing a period of hairpin loop structure,the length of 70-80 nt and single stranded RNA precursors (pre-miRNA) with Dicer or nuclease as similar as Dicer.They primarily function posttranscriptionally by base pairing to sequence motifs in the 3' untranslated region (3'UTR) of target mRNAs in a sequence-specific,tissue-specific and developmental stagespecific matter.1-3 miRNAs have the role of regulation of cell proliferation and death,neuronal differentiation,ontogeny and other biological function.In 2006,scientists noticed that miRNAs play an extremely important role in the occurrence and development process of heart disease.To date,many miRNAs that play a role in diverse aspects of cardiac remodeling and heart failure development have been identified. | Xing Yujie Gao Dengfeng Liu Zhongwei Niu Xiaolin | 2014 | Chinese Medical Journal2014，，18： | 4 |
| 4 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 5 | Garment embedded sweat-activated batteries in wearable electronics for continuous sweat monitoring显示文摘Thin,soft,and skin-integrated electronic system has great advantages for realizing continuous human healthcare monitoring.Here,we report an ultra-thin,flexible,and garment-based microelectronics powered by sweat-activated batteries(SABs)and applications of powering biosensors and microelectronic systems for real time sweat monitoring.The SAB cell is ultra-thin(1.25 mm)with excellent biocompatibility.The SAB has good electricity output with high capacity(14.33 mAh)and maximum power density(3.17 mW cm^(−2))after being activated by the sweat volume of 0.045 mL cm^(−2),which could continuously power 120 light emitting diodes over 3 h.The outputs could maintain stable after repeatable bending.Wireless microelectronics system could be continuously powered by the SABs for 3 h to monitor sweat and physiological information,including sweat Na+concentration,pH,and skin impedance.The reported integrated system provides a potential for solving the power issues of flexible wearable electronics and realizing personalized medicine. | Xingcan Huang Yiming Liu Jingkun Zhou Sina Khazaee Nejad Tsz Hung Wong Ya Huang Hu Li Chun Ki Yiu Wooyoung Park Jian Li Jingyou Su Ling Zhao Kuanming Yao Mengge Wu Zhan Gao Dengfeng Li Jiyu Li Rui Shi Xinge Yu | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 6 | Trimetazidine: a meta-analysis of randomized controlled trials in heart failure Heart 显示文摘 | Dengfeng Gao Ning Ning Xiaolin Niu etal | 2011 | Heart2011，97，4： | 1 |
| 7 | Mechanoluminescent hybrids from a natural resource for energy-related applications显示文摘Mechanoluminescent(ML)materials that directly convert mechanical energy into photon emission have emerged as promising candidates for various applications.Despite the recent advances in the development of both novel and conventional ML materials,the limited access to ML materials that simultaneously have the attributes of high brightness,low cost,self-recovery,and stability,and the lack of appropriate designs for constructing ML devices represent significant challenges that remain to be addressed to boost the practical application of ML materials.Herein,ML hybrids derived from a natural source,waste eggshell,with the aforementioned attributes are demonstrated.The introduction of the eggshell not only enables the preparation of the hybrid in a simple and cost-effective manner but also contributes to the homochromatism(red,green,or blue emission),high brightness,and robustness of the resultant ML hybrids.The significant properties of the ML hybrids,together with the proposed structural design,such as porosity or core–shell structure,could expedite a series of mechanic-optical applications,including the self-luminous shoes for the conversion of human motions into light and light generators that efficiently harvest water wave energy.The fascinating properties,versatile designs,and the efficient protocol of“turning waste into treasure”of the ML hybrids represent significant advances in ML materials,promising a leap to the practical applications of this flouring material family. | Chunfeng Wang Ronghua Ma Dengfeng Peng Xianhu Liu Jing Li Boru Jin Aixian Shan Yu Fu Lin Dong Wenchao Gao Zhong Lin Wang Caofeng Pan | 2021 | InfoMat2021，3，11： | 1 |
| 8 | Serum level of galectin-3 and its clinical significance in patients with chronic Keshan disease显示文摘Objective: Keshan disease (KD) is a fatal endemic dilated cardiomyopathy with unclear etiology and pathogenesis, and a high mortality in China. Pathologic studies confirmed that different degree of myocardial fibrosis existed in various types of KD. Myocardial fibrosis is an important contributor to the pathophysiology of left ventricular remodeling. Recently, galectin-3 (Gal-3) as a marker of cardiac fibrosis and heart failure was approved by the US FDA. The aim of this study was to evaluate the changes of serum level of Gal-3 in chronic KD (CKD) and their clinical implications. Methods: The levels of serum Gal-3 were measured by using enzyme-linked immunosorbent assay (ELISA) in 37 CKD patients and 32 healthy controls. Echocardiography was used to determine parameter of left ventricular ejection fraction (LVEF) and left ventricular end-diastolic dimension (LVEDD). Results: The serum concentration of Gal-3 ([95.81±18.99] ng/ml versus [48.16±11.09] ng/ml, t=6.906, P<0.001) and LVEDD ([60.46±7.63] mm versus (42.69±10.66) mm, t=3.61, P<0.01) were significantly higher, while LVEF ([42.69±10.66]% versus [62.16±6.38]%, t=4.679, P<0.01) were significantly lower in CKD patients compared with healthy controls. A negative correlation was found between elevated Gal-3 and lower LVEF (r=-0.882, P<0.001) and a positive correlation was found between elevated Gal-3 levels and enlarged LVEDD (r=0.834, P<0.001) or higher NYHA class (r=0.854, P<0.01) in CKD patients. Conclusion: Serum concentration of Gal-3 is strongly correlated with poorer left ventricular systolic function, enlarged LVEDD and higher New York Heart Association (NYHA) class, which may provide indirectly diagnostic information on myocardial fibrosis and heart function in CKD patients. | SUN Yuxiao LIU Xin GAO Dengfeng DONG Xin ZHU Canzhan HAN Zhenhua YUAN Yiqiang ZHU Yanhe NIU Xiaolin | 2013 | Journal of Medical Colleges of PLA(China)2013，28，3： | 1 |
| 9 | Miniaturization of mechanical actuators in skin-integrated electronics for haptic interfaces显示文摘Skin-integrated electronics,also known as electronic skin(e-skin);are rapidly developing and are gradually being adopted in biomedical fields as well as in our daily lives.E-skin capable of providing sensitive and high-resolution tactile sensations and haptic feedback to the human body would open a new e-skin paradigm for closed-loop human-machine interfaces.Here,we report a class of materials and mechanical designs for the miniaturization of mechanical actuators and strategies for their integration into thin,soft e-skin for haptic interfaces.The mechanical actuators exhibit small dimensions of 5 mm diameter and 1.45 mm thickness and work in an electromagnetically driven vibrotactile mode with resonance frequency overlapping the most sensitive frequency of human skin.Nine mini actuators can be integrated simultaneously in a small area of 2 cm×2 cm to form a 3×3 haptic feedback array,which is small and compact enough to mount on a thumb tip.Furthermore,the thin,soft haptic interface exhibits good mechanical properties that work properly during stretching,bending,and twisting and therefore can conformally fit onto various parts of the human body to afford programmable tactile enhancement and Braille recognition with an accuracy rate over 85%. | Dengfeng Li Jiahui He Zhen Song Kuanming Yao Mengge Wu Haoran Fu Yiming Liu Zhan Gao Jingkun Zhou Lei Wei Zhengyou Zhang Yuan Dai Zhaoqian Xie Xinge Yu | 2021 | Microsystems & Nanoengineering2021，7，5： | 1 |
| 10 | Join operations in temporal databases显示文摘 | Dengfeng Gao Christian S. Jensen Richard T. Snodgrass Michael D. Soo | 2005 | The VLDB Journal2005，，1： | 1 |
| 11 | Trimetazidine: a meta - analysis of randomised controlled trials in heart failure显示文摘 | Dengfeng Gao Ning Ning Xiaolin Niu | 2011 | Heart2011，97，4： | 1 |
| 12 | Recent progress of skin-integrated electronics for intelligent sensing显示文摘Skin-integrated electronics are a novel type of wearable devices that are mounted on the skin for physiological signal sensing and healthcare monitoring.Their thin,soft,and excellent mechanical properties(stretching,bending,and twisting)allow non-irritating and conformal lamination on the human skin for multifunctional intelligent sensing in real time.In this review,we summarise the recent progress in the intelligent functions of skinintegrated electronics,including physiological sensing,sensory perception,as well as virtual and augmented reality(VR/AR).The detailed applications of these electronics include monitoring physical-and chemical-related health signals,detecting body motions,and serving as the artificial sensory components for visual-,auditory-,and tactilebased sensations.These skin-integrated systems contribute to the development of next-generation e-eyes,e-ears,and e-skin,with a particular focus on materials and structural designs.Research in multidisciplinary materials science,electrical engineering,mechanics,and biomedical engineering will lay a foundation for future improvement in this field of study. | Dengfeng Li Kuanming Yao Zhan Gao Yiming Liu Xinge Yu | 2021 | Light(Advanced Manufacturing)2021，2，1： | 0 |
| 13 | New discoveries in the field of metabolism by applying single-cell and spatial omics显示文摘Single-cell multi-Omics(SCM-Omics)and spatial multi-Omics(SM-Omics)technologies provide state-of-the-art methods for exploring the composition and function of cell types in tissues/organs.Since its emergence in 2009,single-cell RNA sequencing(scRNA-seq)has yielded many groundbreaking new discoveries.The combination of this method with the emergence and development of SM-Omics techniques has been a pioneering strategy in neuroscience,developmental biology,and cancer research,especially for assessing tumor heterogeneity and T-cell infiltration.In recent years,the application of these methods in the study of metabolic diseases has also increased.The emerging SCM-Omics and SM-Omics approaches allow the molecular and spatial analysis of cells to explore regulatory states and determine cell fate,and thus provide promising tools for unraveling heterogeneous metabolic processes and making them amenable to intervention.Here,we review the evolution of SCM-Omics and SM-Omics technologies,and describe the progress in the application of SCM-Omics and SM-Omics in metabolism-related diseases,including obesity,diabetes,nonalcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD).We also conclude that the application of SCM-Omics and SM-Omics approaches can help resolve the molecular mechanisms underlying the pathogenesis of metabolic diseases in the body and facilitate therapeutic measures for metabolism-related diseases.This review concludes with an overview of the current status of this emerging field and the outlook for its future. | Baocai Xie Dengfeng Gao Biqiang Zhou Shi Chen Lianrong Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，7： | 0 |
| 14 | Decrease of Matrix Plasticity Promotes Fibroblast Activation in Fibrosis显示文摘This work identified the important role of matrix mechanical plasticity in mediating fibroblast activation.Many existing studies have highlighted the important effects of biochemical cues(e.g.,transforming growth factor-β1)and mechanicalstiffness on fibroblast activation.Our results indicated that self-assembled collagen hydrogels showed high plasticity and in which fibroblasts remain undifferentiated.However,when we decreased the plasticity of collagen hydrogels by increasing covalent crosslinking,fibroblasts showed a significant fibrotic response as reflected by the increasedα-SMA expression.Since the material systems we constructed have low and the same initial modulus,this process is stiffness independent.Although it has been reported that covalently crosslinked hydrogels are more difficult to degrade and matrix degradability has an important impact on cell behaviors,no significant changes of fibroblast activation were observed when proteases were broadly inhibited in our experiments.Importantly,the hydrogels we constructed showed similar plastic behaviors under creep and recovery tests compared to native normal and fibrotic tissues.These highlight the importance of matrix plasticity in mimicking the mechanical microenvironment of native fibrotic tissues.Mechanistically,we found that the enhanced fibroblast activation in low plastic matrix is mediated through integrin-actin pathway and nuclear localization of YAP.In high plastic collagen,matrix cannot provide effective resistance to actin contraction because of the rupture of weak crosslinks and the slippage of local fibers.On the contrary,in low plastic collagen,deformation energy can be stored in the network due to the existence of strong covalent crosslinks,thus enabling the build-up of cell traction and the formation of a robust cell-matrix interaction.Experiments of inhibiting or promoting cytoskeletal contractility and CGMD simulation both verified the above points.Our results clarify plasticity changes on the development of fibrotic diseases and highlight plasticity as an important mechanical cue in understanding cell-matrix interactions. | Yuanbo Jia Yanzhong Wang Lele Niu Hang Zhang Jin Tian Dengfeng Gao Xiaohui Zhang Tian Jian Lu Jin Qian Guoyou Huang Feng Xu | 2019 | 医用生物力学2019，34，A01： | 0 |
| 15 | Stretchable magnesium-air battery based on dual ions conducting hydrogel for intelligent biomedical applications显示文摘Flexible and bio-integrated electronics have attracted great attention due to their enormous contributions to personalized medical devices.Power sources,serving as one of the most important components,have been suffering from many problems,including deficient biocompatibility,poor stretchability,and unstable electrical outputs under deformed conditions,which limits the practical applications in flexible and bio-integrated electronics.Here,we reported a fully stretchable magnesium(Mg)–air battery based on dual-ions-conducting hydrogels(SDICH).The high-performance battery enables long-term operation with lighting 120 lighting emitting diodes(LEDs)for over 5 h.Benefiting from the advanced materials and mechanical designs,the battery exhibits stability electrical outputs under stretching,which allows to operate ordinarily under various mechanical deformations without performance decay.Furthermore,the great biocompatibility of the battery offers great opportunity for biomedical applications,which is demonstrated by a self-adaption wound dressing system.The in vitro and in vivo results prove that the self-adaption wound dressing can effectively prevent wound inflammation and promote wound healing.By exploiting thermal feedback mechanics,the system can adjust antibiotic release rate and dosage spontaneously according to the real-time wound conditions.The proposed fully stretchable Mg-air battery and self-adaption wound dressing display great potential in skin-integrated electronics and personalized medicine. | Xingcan Huang Yiming Liu Wooyoung Park Zhao Zhao Jiyu Li Chee Kent Lim Tsz Hung Wong Chun Ki Yiu Yuyu Gao Jingkun Zhou HuLi Ling Zhao Jian Li Binbin Zhang Ya Huang Rui Shi Dengfeng Li Jiaying Mo Jinpei Wang Chao Zhang Yuhang Li Zuankai Wang Xinge Yu | 2023 | InfoMat2023，5，3： | 0 |
| 16 | Thin,soft,3D printing enabled crosstalk minimized triboelectric nanogenerator arrays for tactile sensing显示文摘With the requirements of self-powering sensors in flexible electronics,wearable triboelectric nanogenerators(TENGs)have attracted great attention due to their advantages of excellent electrical outputs and low-cost processing routes.The crosstalk effect between adjacent sensing units in TENGs significantly limits the pixel density of sensor arrays.Here,we present a skin-integrated,flexible TENG sensor array with 100 sensing units in an overall size of 7.5 cm×7.5 cm that can be processed in a simple,low-cost,and scalable way enabled by 3D printing.All the sensing units show good sensitivity of 0.11 V/kPa with a wide range of pressure detection from 10 to 65 kPa,which allows to accurately distinguish various tactile formats from gentle touching(as low as 2 kPa)to hard pressuring.The 3D printing patterned substrate allows to cast triboelectric layers of polydimethylsiloxane in an independent sensing manner for each unit,which greatly suppresses the cross talk arising from adjacent sensing units,where the maximum crosstalk output is only 10.8%.The excellent uniformity and reproducibility of the sensor array offer precise pressure mapping for complicated pattern loadings,which demonstrates its potential in tactile sensing and human-machine interfaces. | Jian Li Yiming Liu Mengge Wu Kuanming Yao Zhan Gao Yuyu Gao Xingcan Huang Tsz Hung Wong Jingkun Zhou Dengfeng Li Hu Li Jiyu Li Ya Huang Rui Shi Junsheng Yu Xinge Yu | 2023 | Fundamental Research2023，3，1： | 0 |
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