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| 1 | Diabetic cardiomyopathy:Pathophysiology,diagnostic evaluation and management显示文摘Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population.Diabetes-related heart disease occurs in the form of coronary artery disease(CAD),cardiac autonomic neuropathy or diabetic cardiomyopathy(DbCM).The prevalence of cardiac failure is high in the diabetic population and DbCM is a common but underestimated cause of heart failure in diabetes.The pathogenesis of diabetic cardiomyopathy is yet to be clearly defined.Hyperglycemia,dyslipidemia and inflammation are thought to play key roles in the generation of reactive oxygen or nitrogen species which are in turn implicated.The myocardial interstitium undergoes alterations resulting in abnormal contractile function noted in DbCM.In the early stages of the disease diastolic dysfunction is the only abnormality,but systolic dysfunction supervenes in the later stages with impaired left ventricular ejection fraction.Transmitral Doppler echocardiography is usually used to assess diastolic dysfunction,but tissue Doppler Imaging and Cardiac Magnetic Resonance Imaging are being increasingly used recently for early detection of DbCM.The management of DbCM involves improvement in lifestyle,control of glucose and lipid abnormalities,and treatment of hypertension and CAD,if present.The role of vasoactive drugs and antioxidants is being explored.This review discusses the pathophysiology,diagnostic evaluation and management options of DbCM. | Joseph M Pappachan George I Varughese Rajagopalan Sriraman Ganesan Arunagirinathan | 2013 | World Journal of Diabetes2013，4，5： | 57 |
| 2 | Diabetes mellitus and stroke: A clinical update显示文摘Cardiovascular disease including stroke is a major complication that tremendously increases the morbidity and mortality in patients with diabetes mellitus(DM). DM poses about four times higher risk for stroke. Cardiometabolic risk factors including obesity, hypertension, and dyslipidaemia often co-exist in patients with DM that add on to stroke risk. Because of the strong association between DM and other stroke risk factors, physicians and diabetologists managing patients should have thorough understanding of these risk factors and management. This review is an evidence-based approach to the epidemiological aspects, pathophysiology, diagnostic work up and management algorithms for patients with diabetes and stroke. | Nyo Nyo Tun Ganesan Arunagirinathan Sunil K Munshi Joseph M Pappachan | 2017 | World Journal of Diabetes2017，8，6： | 15 |
| 3 | Heterologous biosynthesis of natural product naringenin by co-culture engineering显示文摘Co-culture engineering is an emerging approach for microbial biosynthesis of a variety of biochemicals.In this study,E.coli-E.coli co-cultures were developed for heterologous biosynthesis of the natural product naringenin.The co-cultures were composed of two independent E.coli strains dedicated to functional expression of different portions of the biosynthetic pathway,respectively.The co-culture biosynthesis was optimized by investigating the effect of carbon source,E.coli strain selection,timing of IPTG induction and the inoculation ratio between the co-culture strains.Compared with the monoculture strategy,the utilization of the designed co-cultures significantly improved the naringenin production,largely due to the reduction of metabolic stress,employment of proper hosts for improving pathway enzyme activities,and flexible adjustment of the relative biosynthetic strength between the coculture strains.The findings of this study extend the applicability of co-culture engineering in complex natural product biosynthesis. | Vijaydev Ganesan Zhenghong Li Xiaonan Wang Haoran Zhang | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 13 |
| 4 | Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression显示文摘Hepatotropic viruses induced hepatitis progresses much faster and causes more liver-related health problems in people co-infected with human immunodeficiency virus(HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus(HBV) and hepatitis C virus(HCV) causes significant numbers of non-acquired immune deficiency syndrome(AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals(DAA) and antiretroviral therapy(ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals. | Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2019 | World Journal of Gastroenterology2019，25，4： | 12 |
| 5 | A review of neural networks in plant disease detection using hyperspectral data显示文摘This paper reviews advanced Neural Network(NN)techniques available to process hyperspectral data,with a special emphasis on plant disease detection.Firstly,we provide a review on NN mechanism,types,models,and classifiers that use different algorithms to process hyperspectral data.Then we highlight the current state of imaging and nonimaging hyperspectral data for early disease detection.The hybridization of NNhyperspectral approach has emerged as a powerful tool for disease detection and diagnosis.Spectral Disease Index(SDI)is the ratio of different spectral bands of pure disease spectra.Subsequently,we introduce NN techniques for rapid development of SDI.We also highlight current challenges and future trends of hyperspectral data. | Kamlesh Golhani Siva K.Balasundram Ganesan Vadamalai Biswajeet Pradhan | 2018 | Information Processing in Agriculture2018，5，3： | 9 |
| 6 | Anaerobic tapered fluidized bed reactor for starch wastewater treatment and modeling using multilayer perceptron neural network显示文摘合成西米废水的厌氧的对待能力在一个实验室被调查厌氧的逐渐变细的使流体化的床反应堆(ATFBR ) 与一我酣睡的小粒的活性炭(GAC ) 作为支持材料。试验性的协议被定义检验最大的器官的装载率(OLR ) 的效果,水力的保留时间(HRT ) ,反应堆并且到它的稳定的州的表演上的报告的效率。反应堆在 OLR 的一个范围上受到不变的操作直到 85.44 kg COD/(m3 · d ) 。当在浸煮器蒸煮器; 消化剂生产的简历气体到达了反应堆的 25.38 m3/(m3 · d ) 时,货到付款移动效率被发现在反应堆是 92% 。随从 83.7 kg COD/(m3 · d ) 的 OLR 的增加, COD 移动效率减少了。另外,用多层的视感控器(MLP ) 的一个人工的神经网络(ANN ) 模型为二个输入变量和五个输出依变数的一个系统被开发了。为训练输入产量数据,获得的实验值被使用了。预言的产量参数被发现了离相应的试验性的靠近得多,模型为 30% 未经训练的数据被验证。均方差(MSE ) 被发现仅仅是 0.0146。 | RANGASAMY Parthiban PVR Iyer GANESAN Sekaran | 2007 | Journal of Environmental Sciences2007，19，12： | 8 |
| 7 | Stem cells:An eventual treatment option for heart diseases显示文摘Stem cells are of global excitement for various diseases including heart diseases. It is worth to understand the mechanism or role of stem cells in the treatment of heart failure. Bone marrow derived stem cells are commonly practiced with an aim to improve the function of the heart. The majority of studies have been conducted with acute myocardial infarction and a few has been investigated with the use of stem cells for treating chronic or dilated cardiomyopathy. Heterogeneity in the treated group using stem cells has greatly emerged. Ever increasing demand for any alternative made is of at most priority for cardiomyopathy. Stem cells are of top priority with the current impact that has generated among physicians. However,meticulous selection of proper source is required since redundancy is clearly evident with the present survey. This review focuses on the methods adopted using stem cells for heart diseases and outcomes that are generated so far with an idea to determine the best therapeutic possibility in order to fulfill the present demand. | Joseph C Bilgimol Subbareddy Ragupathi Lakshmanan Vengadassalapathy Nathan S Senthil Kali-muthu Selvakumar M Ganesan Sadananda Rao Manjunath | 2015 | World Journal of Stem Cells2015，7，8： | 6 |
| 8 | A critical review on phytochemical profile and health promoting effects of mung bean (Vigna radiata)显示文摘The seeds and sprouts of mung bean are very common cruise in Asia.Evidence showed that bioactive compounds in mung bean have emerged as an increasing scientific interest due to their role in the prevention of degenerative diseases.All data of in vitro,in vivo and clinical studies of mung bean and its impact on human health were collected from a library database and electronic search.Botanical,phytochemical and pharmacological information was gathered and orchestrated.Remarkable studies have been demonstrated,showing the enhancement of metabolites in mung bean during the sprouting process,which possesses various health benefiting bioactive compounds.These compounds have been frequently attributed to their antioxidant,anti-diabetic,antimicrobial,anti-hyperlipidemic and antihypertensive effect,anti-inflammatory,and anticancer,anti-tumor and anti-mutagenic properties.In this critical review,we aimed to study the insight of the nutritional compositions,phytochemistry,and healthpromoting effects of mung bean and its sprouts.The various curative potential of mung bean provides successive preclinical outcomes in the field of drug discovery and this review strongly recommends that mung bean is an excellent nutritive legume,which modulates or prevents chronic degenerative diseases. | Kumar Ganesan Baojun Xu | 2018 | Food Science and Human Wellness2018，7，1： | 6 |
| 9 | Liver as a target of human immunodeficiency virus infection显示文摘Liver injury is a characteristic feature of human immunodeficiency virus(HIV) infection, which is the second most common cause of mortality in HIV-infected patients. Now it is recognized that liver plays a key role in HIV infection pathogenesis. Antiretroviral therapy(ART), which suppresses HIV infection in permissive immune cells, is less effective in hepatocytes, thereby making these cells a silent reservoir of HIV infection. In addition to direct hepatotoxic effects of HIV, certain ART treatment modalities provide hepatotoxic effects. The exact mechanisms of HIV-triggered chronic hepatitis progression are not elucidated, but the liver is adversely affected by HIV-infection and liver cells are prominently involved in HIV-elicited injury. These effects are potentiated by second hits like alcohol. Here, we will focus on the incidence of HIV, clinical evidence of HIVrelated liver damage, interactions between HIV and liver cells and the role of alcohol and co-infection with hepatotropic viruses in liver inflammation and fibrosis progression. | Murali Ganesan Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2018 | World Journal of Gastroenterology2018，24，42： | 5 |
| 10 | Endocrine milieu and erectile dysfunction: is oestradio-testosterone imbalance, a risk factor in the elderly?显示文摘雌激素不对女性独占,但是在 25-70 的中等传播层次发生; pg 在男人的 ml −1 ,与 44-153 相比; pg 在女人的 ml −1 。从睾丸激素(T) 的 aromatisation 产生,雌激素被认为有许多在变老的男性反对生理的功能和进步 T 衰落与浆液 oestradiol 的相对或绝对的增加被联系(E 2) 。性公正和可勃起的机能障碍(编辑) 在老很可能由于 pathophysiological E 2-T 不平衡;改变的神经质的比率可以也向 environmental/plant 雌激素在 hyperestrogenism 或后面的暴露解释编辑的更高的发生。 | Balasubramanian Srilatha P Ganesan Adaikan | 2011 | Asian Journal of Andrology2011，13，4： | 5 |
| 11 | Role of alcohol in pathogenesis of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)and alcohol abuse often contribute to the development of end-stage liver disease.Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically.Importantly,the mechanism by which alcohol promotes the progression of HBVassociated liver disease are not completely understood.Potential mechanisms include a suppressed immune response,oxidative stress,endoplasmic reticulum and Golgi apparatus stresses,and increased HBV replication.Certainly,more research is necessary to gain a better understanding of these mechanisms such that treatment(s)to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed.In this review,we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field. | Murali Ganesan Allison Eikenberry Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2020 | World Journal of Gastroenterology2020，26，9： | 5 |
| 12 | 微博信息采集及群体行为分析显示文摘随着在线社会关系网络的迅猛发展,每天数以千万计的人通过发表、评论、分享等方式,产生和传播各类话题.对在线社会关系数据的感知与收集、存储管理、群体行为等进行研究,能更好地挖掘和分析社会关系网络.由于微博平台的登录、数据显示与处理等方面与传统网络平台有很大差异,传统网络爬虫不适于对微博信息的全面抓取.本文采用模拟用户浏览行为方法来爬取海量微博数据,通过数据包截取与分析等手段获取相关信息.实验结果表明该方法的有效性.在此基础上,以收集的微博数据为研究对象,对群体行为进行了分析. | 高凯 王九硕 马红霞 周二亮 Radha Ganesan | 2013 | 小型微型计算机系统2013，34，10： | 5 |
| 13 | Diabetes--Role of epigenetics,genetics,and physiological factors显示文摘Cells of organ systems are endowed with a relatively similar genome while epigenome niches keep varying chronologically and defined explicitly in the respective tissues.The genome of an individual is always influenced by parental,embryonic,tissue-specific,and environmental epigenomes and the same must have been the possible reason for invariable inquiries relating to familial,environmental and life style patterns in the preliminary investigations of diabetic complications.Unprecedented methylation of lysine residues of histones and cytosines of CpG islands of promoter DNA impede the transcription of genes and homocysteine is the metabolic key player of methyl groups.Gck and COX7A1 are the 2 examples in the present review to elucidate the epigenetic influence on the onset of diabetes.miRNAs are additional promising cellular components influencing both at transcriptional and translational levels and promoting either in favour or against(i.e.,feed back) TFs,signaling factors and proteins through their pliotropic effects and thus are reported to regulate cellular physiology.miR-124a and miR-9 are primarily endemic to nervous tissue and they are now being exploited in islets for their function in executing exocytosis of insulin,which of course is one of the fundamental canons of diabetes.miR-375 persuades beta cells for glucose-induced insulin gene expression.The current approach to evaluate the constellation of genes and their products involved in diabetes in huge number of samples through GWA studies may unravel intricacies involved in the management of diabetes and its associated consequences. | Sreerama Krupanidhi Saikiran K. Sedimbi Ganesan Vaishnav Sreerama Sai Madhukar Carani B. Sanjeevi | 2009 | 中南大学学报(医学版)2009，34，9： | 3 |
| 14 | An innovative approach to minimize excess sludge production in sewage treatment using integrated bioreactors显示文摘The present investigation deals with an application of integrated sequential oxic and anoxic bioreactor(SOABR) and fluidized immobilized cell carbon oxidation(FICCO) reactor for the treatment of domestic wastewater with minimum sludge generation. The performance of integrated SOABR-FICCO system was evaluated on treating the domestic wastewater at hydraulic retention time(HRT) of 3 hr and 6 hr for 120 days at organic loading rate(OLR)of 191 ± 31 mg/(L·hr). The influent wastewater was characterized by chemical oxygen demand(COD) 573 ± 93 mg/L; biochemical oxygen demand(BOD5) 197 ± 35 mg/L and total suspended solids(TSS) 450 ± 136 mg/L. The integrated SOABR-FICCO reactors have established a significant removal of COD by 94% ± 1%, BOD5 by 95% ± 0.6% and TSS by 95% ± 4% with treated domestic wastewater characteristics COD 33 ± 5 mg/L; BOD59 ± 0.8 mg/L and TSS 17 ± 9 mg/L under continuous mode of operation for 120 days. The mass of dry sludge generated from SOABR-FICCO system was 22.9 g/m^3. The sludge volume index of sludge formed in the SOABR reactor was 32 mL/g and in FICCO reactor it was 46 mL/g. The sludge formed in SOABR and FICCO reactor was characterized by TGA, DSC and SEM analysis. Overall, the results demonstrated that the integrated SOABR-FICCO reactors substantially removed the pollution parameters from domestic wastewater with minimum sludge production. | Mahesh Mannacharaju Prabhakaran Natarajan Arivizhivendhan Kannan Villalan Madasamy Jothieswari Swarnalatha Somasundaram Sekaran Ganesan | 2018 | Journal of Environmental Sciences2018，30，5： | 3 |
| 15 | Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats显示文摘The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats.Thirty rats were categorized as control,diabetic control supplemented with 0,20 mg/kg chrysoeriol and 600μg/kg BW of glibenclamide for 45-day trial period.Our results indicated that the inclusion of chrysoeriol(20 mg/kg)showed a significant reduction in plasma glucose,hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity.Further,downregulated enzymes including glucose 6-phosphatase,fructose 1,6-bisphosphatase,and glycogen phosphorylase as well upregulated enzymes such as hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,and hepatic glycogen content.There was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase,towards normal levels upon treatment with chrysoeriol.The histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated rats.In addition,the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide,as a standard drug.Thus,chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes. | Baskaran Krishnan Abirami Ramu Ganesan Ravindran Balasubramani Dinh Duc Nguyen Soon Woong Chang Shaoyun Wang Jianbo Xiao Balamuralikrishnan Balasubramanian | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 16 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 17 | Secondary metabolite credentials ofEvolvulus alsinoides by high performance thin layer chromatography(HPTLC)显示文摘Plants and plant-based products are the bases of many modern pharmaceuticals that are current in use today for various diseases.The aim of the study was to investigate the biochemical constituents and high performance thin layer chromatography(HPTLC) finger printing of the ethanolic extract of Evolvulus alsinoides.Phytochemical screening was done by standard procedures and HPTLC method was also established to analyze alkaloids,flavonoids and phenolic compounds from the ethanolic extract of Evolvulus alsinoides.Preliminary phytochemical screening showed that ethanol extracted more secondary metabolites than other solvents.HPTLC fingerprinting analysis showed the presence of various alkaloids,flavonoids and phenols(quercetin) in the ethanolic extract.It can be concluded that Evolvulus alsinoides may serve as a source of potent antioxidants that may be used in the prevention of various diseases such as cancer,diabetes and cardiovascular diseases due to the presence of phenolic compounds.HPTLC finger print of Evolvulus alsinoides may be useful in the differentiation of the species from adulterants and act as a biochemical marker for this medicinally important plant in the pharmaceutical industry and plant systematic studies. | Duraisamy Gomathi Manokaran Kalaiselvi Ganesan Ravikumar Dominic Sophia Velliyur Kanniappan Gopalakrishnan Chandrasekar Uma | 2012 | The Journal of Biomedical Research2012，26，4： | 2 |
| 18 | In vitro antiplasmodial activity of Spiro benzofuran compound from mangrove plant of Southern India显示文摘Objective:To find out the in vitro antipalsmodial activities of mangrove leaf extracts.Methods: In vitro antiplasmodial assay was carried out with 13 different mangrove plants.Column chromatography was performed with the most potent Agecerious corniculatum(A.corniculatum) by using various solvent extractions.GC-MS was also preformed with the most potent ethanolic fraction of the A.corniculatum extract.Results:Of the 13 mangroves plants, A.corniculatum showed maximum percentage of parasitemia suppression(94.98±1.16)%.Column chromatography was performed with A.corniculatum with different solvents and the methanolic extract showed maximum percentage(99.73±1.63)%of parasitemia inhibition at 150μg/mL concentration with the IC50 value of(29.28±3.23)μg/mL concentration.The results of the GC-MS analysis observed that,the most potent methanolic extract showed maximum retention time(30.687 RT) and the chemical class was identified as Spiro[benzofuran-2(3 H),1’-(3 cyclohexane)-2’,3- dione,7-chloro-4’,6]which was responsible for the antiplasmodial activity.Conclusions:It is concluded from the present study that,the chemical constituents of A.corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future. | Sundaram Ravikumar Ganesan Ramanathan Murugesan Gnanadesigan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 2 |
| 19 | Studies on the Functional Properties of Protein Concentrate of Kappaphycus alvarezii (Doty) Doty – An Edible Seaweed显示文摘 | K. Suresh Kumar K. Ganesan Kandasamy Selvaraj P.V. Subba Rao | 2013 | Food Chemistry2013，，： | 2 |
| 20 | Controlling the solid-state luminescence of gold(I) N-heterocyclic carbene complexes through changes in the structure of molecular aggregates显示文摘Thermally stable, solid-state luminescent organic materials are highly desired for the development of practical applications.Herein we synthesized new gold(I) complexes with N-heterocyclic carbene ligands, which have the ability to form strong metalorganic bond. Consequently, their thermochemical stability is enhanced at temperatures around 300 °C. Precise design of the molecular structure of the ligands, with a focus on ensuring low steric hindrance around Au atoms in order to limit disturbances to Au/Au interactions, provided a complex with a densely packed crystal with a shorter intermolecular Au–Au distance(3.17 ?)than the typical distance. In the solid state, this complex exhibited strong aurophilic interactions, which generated intense phosphorescence even in air at room temperature(quantum yield=16%) in spite of absence of any phosphorescence in solution.This behavior is characteristic for solid-state luminescence referred to as aggregation-controlled emission. Furthermore, the gold(I) complex displays capacity for mechano-and vapo-chromism—that is, the ability to change color reversibly in response to the application of external stimuli. We believe that the proposed design framework, which involves controlling thermal stability and luminescence property separately, provides a new opportunity for the development of practical applications using solid-state luminescent organic molecules. | Arruri Sathyanarayana Shin-ya Nakamura Kyohei Hisano Osamu Tsutsumi Katam Srinivas Ganesan Prabusankar | 2018 | Science China Chemistry2018，61，8： | 2 |
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