|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ERCP in acute pancreatitis:What takes place in routine clinical practice?显示文摘AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the Pancreas.METHODS:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of symptoms.The main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) respectively.The success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic procedure.CONCLUSION:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy. | Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai Laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 2 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Diagnostic yield of EUS-FNA of small(≤15 mm) solid pancreatic lesions using a 25-gauge needle显示文摘Background: Early detection of small solid pancreatic lesions is increasingly common. To date, few and contradictory data have been published about the relationship between lesion size and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) diagnostic yield. The aim of this study was to assess the relation between the size of solid pancreatic lesions and the diagnostic yield of EUS-FNA using a 25-gauge needle in a center without available rapid on-site evaluation.Methods: In the retrospective cohort study, we selected patients who underwent EUS-FNA for solid pancreatic lesions with a 25-gauge needle from October 2014 to October 2015. Patients were divided into three groups(≤15 mm, 16–25 mm and >25 mm), and the outcomes were compared.Results: We analyzed 163 patients. Overall adequacy, sensitivity, specificity and accuracy were 85.2%,81.8%, 93.7%, and 80.4%, respectively. When stratified by size, the sensitivity and accuracy correlated with size(P = 0.016 and P = 0.042, respectively). Multivariate analysis showed that lesion size was the only independent factor(P = 0.019, OR = 4.76) affecting accuracy. The role of size as an independent factor affecting accuracy was confirmed in a separate multivariate analysis, where size was included in the model as a covariate(P = 0.018, OR = 1.08).Conclusion: Our study demonstrates that, in the absence of rapid on-site evaluation, mass size affects the accuracy of EUS-FNA of solid pancreatic lesions. | Stefano Francesco Crinò Maria Cristina Conti Bellocchi Laura Bernardoni Erminia Manfrin Alice Parisi Antonio Amodio Nicolò De Pretis Luca Frulloni Armando Gabbrielli | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 4 | Response to cadmium in higher plants显示文摘 | L Sanità di Toppi R Gabbrielli | 1999 | Environmental and Experimental Botany1999，，2： | 2 |
| 5 | Response to cadmium in higher plants 显示文摘 | TOPPI L S D GABBRIELLI R | 1999 | Environmental & Experimental Botany1999，41，2： | 1 |
| 6 | Response to cadmium in higher plants 显示文摘 | Di Toppi L S Gabbrielli R | 1999 | Environ Exp Bot1999，41，： | 1 |
| 7 | Monte Carlo simulation approach for a modified FMECA in a power plant显示文摘 | BEVILACQUA M BRAGLIA M GABBRIELLI R | | 0，，04： | 1 |
| 8 | Response to cadmium in higher plants 显示文摘 | Sanita Di Toppi L Gabbrielli R | 1999 | Environmental and Experimental Bota- ny1999，41，： | 1 |
| 9 | Response to cadmium in higher plants显示文摘 | SANIT(A) DI T GABBRIELLI R | 1999 | Environmental and Experimental Botuny1999，41，： | 1 |
| 10 | Comparsion of two serpentine spentine species with different nickel tolerance strategies显示文摘 | Gabbrielli R Panddfini T Vergnano O | 1990 | Plant and Soil1990，122，： | 1 |
| 11 | Nickel and copper toler ance and toxicity in three Tuscan populations of Silene para- dooca显示文摘 | Gonnelli C Galardi F Gabbrielli R | 2001 | Physiologia Plantarum2001，113，： | 1 |
| 12 | Diagnosis and treatment of acute pancreatitis: The position statement of the Italian Association for the study of the pancreas显示文摘 | R. Pezzilli G. Uomo A. Zerbi A. Gabbrielli L. Frulloni P. De Rai G. Delle Fave V. Di Carlo | 2008 | Digestive and Liver Disease2008，，10： | 1 |
| 13 | Response to cadmium in higher plants显示文摘 | Sanita di Toppi L Gabbrielli R | 1999 | Environ Exp Bot1999，41，： | 1 |
| 14 | Response to cadmium in higher plants显示文摘 | Sanitadi Toppi L Gabbrielli R | 1999 | Environment Experiment Botany1999，41，： | 1 |
| 15 | Palliation of patients with malignant gastric outlet obstruction with the enteral Wallstent: outcomes from a multicenter study显示文摘 | Jennifer J. Telford David L. Carr-Locke Todd H. Baron Andrea Tringali Willis G. Parsons Armando Gabbrielli Guido Costamagna | 2004 | Gastrointestinal Endoscopy2004，，6： | 1 |
| 16 | A new percutaneous nephrostomy technique in the treatment of obstructive uropathy显示文摘 | Agostini S Dedola G L Gabbrielli S | 2003 | Radiol Med(Torino)2003，105，56： | 1 |
| 17 | Response to cadmium in higher plants显示文摘 | Sanitadi T L Gabbrielli R | 1999 | Environ Exp Bot1999，41，： | 1 |
| 18 | Comparison of two serpentine species with different nickel tolerance strategies显示文摘 | Poberto Gabbrielli T. Pandolfini O. Vergnano M. R. Palandri | 1990 | Plant and Soil1990，，2： | 1 |
| 19 | Diagnostic assessment and outcome of acute pancreatitis in Italy: Results of a prospective multicentre study显示文摘 | G. Uomo R. Pezzilli A. Gabbrielli L. Castoldi A. Zerbi L. Frulloni P. De Rai G. Cavallini V. Di Carlo | 2007 | Digestive and Liver Disease2007，，9： | 1 |
| 20 | Response to cadmium in higher plants显示文摘 | SANITADI TOPPI L GABBRIELLI R | 1999 | Environ Exp Bot1999，41，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员