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| 1 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 2 | Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord显示文摘The aim of this work was to study effects of ketotifen fumarate(KF)on prevention of tissue damage in testes of rats with experimental autoimmune orchitis(EAO)and on the contralateral testis in a model of prolonged testicular cord torsion(TCT).Rats with EAO or TCT were injected intraperitoneally once daily with KF or saline solution(vehicle group).Incidence and severity of testicular damage were evaluated by histopathology using an EAO score or a Johnsen score.Mast cells(MC)were identified by histochemistry and quantified.In EAO model,KF significantly reduced severity of histopathological testicular damage compared to rats in the vehicle group.KF also reduced the number of testicular MC compared to vehicle group.Similarly,in TCT model,multifocal damage of the contralateral testis was observed 30 days after testicular torsion characterized by sloughing of the germinal epithelium,seminiferous tubule atrophy,and interstitial edema.Focal signs of inflammation and fibrosis of seminiferous tubular walls were also observed.In contrast,sections of contralateral testis of rats injected with KF and killed 30 days after surgery showed normal histological features.A significant decrease in the number of MC was observed in rats treated with KF compared to untreated animals.In conclusion,we demonstrated that treatment with KF reduced testicular inflammatory process and MC infiltrates in both EAO and TCT models.The results suggest a promising treatment for infertile male patients with testicular pathologies associated with inflammation and germ cell loss. | Diego Moreno Cristian M Sobarzo Livia Lustig Marcelo G Rodriguez Pena Vanesa Anabella Guazzone | 2020 | Asian Journal of Andrology2020，22，1： | 3 |
| 3 | Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Jorge Saba Alberto Perez-Castilla Manoel Galvao Neto Michael D. Crowell | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 4 | Oleanolic acid promotes healing of acetic acid - induced chronic gastric lesions in rats显示文摘 | Rodriguez J A Astudillo L Schmeda - Hirschmann G | 2003 | Pharmacol Res2003，48，3： | 1 |
| 5 | JAK2/STAT3 directs cardiomyogenesis within murine embryonic stem cells in vitro显示文摘 | Rodriguez G Hoel B et al | 2005 | Stem Cells2005，23，4： | 1 |
| 6 | Connexin43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning显示文摘 | Boengler K Dodoni G Rodriguez - Sinovas A | 2005 | Cardiovasc Res2005，67，2： | 1 |
| 7 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 8 | Simulation platform for MIMO systems 显示文摘 | Bazdreseh M Rodriguez Guisantes G | 2006 | Communications and Computers2006，27，1： | 1 |
| 9 | L-arginine availability regu-lates T-lymphocyte cell-cycle progression显示文摘 | Rodriguez P C Quiceno D G Ochoa A C | 2007 | Blood2007，109，4： | 1 |
| 10 | Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA显示文摘 | Montero C Mateu G Rodriguez R | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 11 | Optimiza- tion of wind farm turbines layout using an evolutive algorithm 显示文摘 | Gonzalez J S Rodriguez A G G Mora J C | 2010 | Renewable Energy2010，35，8： | 1 |
| 12 | Chemical composition of lipophilic extractives from jute (Corchorus capsularis)fibers used for manufacturing of high-quality paper pulps 显示文摘 | Rio Andrade J C Marques G Rodriguez Garcia M I | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 13 | Gout and risk of Parkinson disease: a prospective study显示文摘 | Alonso A Rodriguez L A Logroscino G | 2007 | Neurology2007，69，17： | 1 |
| 14 | 'Very early' intrahepatic cholangiocarcinoma in cirrhotic patients:should liver transplantation be reconsidered in these patients?显示文摘 | Sapisochin G Rodriguez de Lope C Gastaca M | 2014 | Am J transplant2014，14，3： | 1 |
| 15 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 16 | Multieenter phase III comparison of cisplatin/S-I with eisplatin/infusional fluoroura- eil in advanced gastric or gastroesophageal adenocarcinoma study:the FLAGS trial显示文摘 | Ajani JA Rodriguez W Bodoky G | 2010 | J Clin Oncol2010，28，9： | 1 |
| 17 | Soilbiota and exotic plant invasion 显示文摘 | CALLAWAY R M THELEN G C RODRIGUEZ A | 2004 | Nature2004，427，6976： | 1 |
| 18 | The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘 | Rodriguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
| 19 | Vaginal group B streptococcus status during intrapartum antibiotic prophylaxis 显示文摘 | Scasso S Laufer J Rodriguez G | 2015 | lnt J Gynaecol Obstet2015，129，1： | 1 |
| 20 | Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon 显示文摘 | MACIAG A DAINESE E RODRIGUEZ G M | 2007 | J Bacteriol2007，189，3： | 1 |
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