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| 1 | Association of emergency room visits for respiratory diseases with sources of ambient PM2.5显示文摘Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory diseases.Few studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory diseases.Source apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease ERVs.The association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)increase.We found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),respectively.The estimated effects of PM2.5 changed little after adjusting for different air pollutants.Six primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare. | Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo | 2019 | Journal of Environmental Sciences2019，31，12： | 8 |
| 2 | A 5D simulation method on post-earthquake repair process of buildings based on BIM显示文摘The post-earthquake repair process of buildings is one of the key components of building seismic resilience.Understanding the details of the repair process in advance will benefit the evaluation and decision making for the seismic resilience of buildings.To this end,a five-dimensional(5 D)simulation method on the post-earthquake repair process of buildings is proposed based on building information modeling(BIM),by which the repair activities can be presented in the way associated with a 3 D model,time(denoted as the fourth dimension),and the related costs(denoted as the fifth dimension).First,a decision-making model of repair schemes based on the interval index of the possibility degree is created to determine the optimal post-earthquake repair schemes for a damaged building.Subsequently,an algorithm based on separate flowrepetitive process is designed to automatically make the repair schedule on a BIM platform according to the determined repair schemes.Finally,an algorithm of automatic mapping between the components in BIM and their repair schedules is developed,so that a 5 D simulation of a post-earthquake repair process can be implemented.A six-story office building is selected as a case study,and the details of the post-earthquake repair process(e.g.,the costs of labor,material and equipment over the repair time)are presented by the proposed 5 D simulation method.The outcome of this study can be used to evaluate the seismic resilience of buildings and also to facilitate the decision making for seismically resilient buildings by providing the detailed guidance of the repair process. | Xu Zhen Zhang Furong Jin Wei Wu Yingying Qi Mingzhu Yang Yajun | 2020 | Earthquake Engineering and Engineering Vibration2020，19，3： | 4 |
| 3 | Response of organic carbon burial to trophic level changes in a shallow eutrophic lake in SE China显示文摘Lakes are an important component of terrestrial carbon cycling. As the trend of eutrophication in many lakes continues, the mechanisms of organic carbon(OC) burial remain unclear. This paper aims to understand the distribution of OC and the effect of trophic level changes on OC burial in Chaohu Lake, a shallow eutrophic lake located in the lower reaches of the Yangtze River, SE China. Two hundred and one surface sediment samples(0–20 cm) and 53 subsurface samples(150–200 cm) from the lake were collected.The OC accumulation rates(OCARs) are relatively low, with an average of 10.01 g/m2/year in the surface sediments. The spatial distribution of the OCARs is similar to that of allochthonous OC. The difference in total phosphate(TP) content between the surface and subsurface sediments(ΔTP) is significantly correlated with the autochthonous OC,suggesting that TP loading is a critical limiting nutrient for the lake's primary productivity.It is concluded that allochthonous OC is the dominant source of total OC in surface sediments compared to autochthonous OC. The primary productivity of Lake Chaohu increased due to increasing nutrient loading. However, the autochthonous OC contributed11% of the total OC in the surface sediments. This could be ascribed to strong mineralization in the water column or surface sediments. | Pengbao Wu Chao Gao Furong Chen Shiyong Yu | 2016 | Journal of Environmental Sciences2016，28，8： | 2 |
| 4 | Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis显示文摘Whereas it is appreciated that cancer cells rewire lipid metabolism to survive and propagate,the roles of lipid metabolism in metastasis remain largely unknown.In this study,using esophageal squamous cell carcinoma(ESCC)as a pulmonary metastasis model,we find that the enzyme fatty acid 2-hydroxylase(FA2H),which catalyzes the hydroxylation of free fatty acids(FAs),is enriched in a subpopulation of ESCC cells with high metastatic potential,and that FA2H knockdown markedly mitigates metastatic lesions.Moreover,increased FA2H expression is positively associated with poor survival in patients with ESCC.Lipidomics analysis identifies that two dihydroceramides—Cer(d18:0/24:0)and Cer(d18:0/24:1)—are increased in FA2H-depleted metastasizing ESCC cells.Upon administration,Cer(d18:0/24:0)and Cer(d18:0/24:1)impair the formation of overt metastases in a mouse experimental metastasis model.Then,forkhead box protein C2(FOXC2)and FA2H are found to be co-upregulated in metastatic ESCC cell populations and ESCC specimens,and FA2H expression is further experimentally verified to be transcriptionally induced by FOXC2,which is boosted per se by tumour necrosis factorα(TNFα),a critical pro-metastasis cytokine in the tumour microenvironment,in metastasizing cells.Together,these results demonstrate that TNFα-FOXC2-FA2H is a novel signaling axis to promote metastasis,and its downstream dihydroceramide products could be promising drugs to intervene in metastasis. | Xuantong Zhou Furong Huang Gang Ma Wenqing Wei Nan Wu Zhihua Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 2 |
| 5 | Association of Heart Rate Variability in Taxi Drivers with Marked Changes in Particulate Air Pollution in Beijing in 2008显示文摘 | Wu Shaowei Deng Furong Niu Jie Huang Qinsheng Liu Youcheng Guo Xinbiao | 2010 | Environmental Health Perspectives2010，，1： | 1 |
| 6 | Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study显示文摘Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality limits.However,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear.To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period.Repeated health measurements and urine sample collection were conducted in each participant.Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis.Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices.Nine metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid metabolism.Boys may have a greater decrease in bile acid and RNA related metabolites.Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices.Furthermore,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide.Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation.The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure.Indoor ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children. | Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao Guo Furong Deng | 2021 | The Innovation2021，2，1： | 1 |
| 7 | Preparation of graphene by exfoliation of graphite using wet ball milling显示文摘 | Zhao Weifeng Fang Ming Wu Furong | 2010 | Journal of Materials Chemistry2010，20，： | 1 |
| 8 | Occurrence Characteristics of Saline-Lacustrine Shale-Oil in the Qianjiang Depression,Jianghan Basin,Central China显示文摘The amount of shale oil and its characterization are key issues in the study of shale oil.At present,many scholars use a variety of methods to evaluate the amount of shale oil,and use the calculated amount of hydrocarbons to analyze its influencing factors;however,there is lack of detailed research on the storage space for shale-oil and it’s influencing factors.In view of this issue,gas chromatography(GC),gas chromatography-mass spectrometry(GC-MS),soxhlet extraction(SE),fieldemission scanning electron microscopy(FE-SEM),low-temperature nitrogen adsorption(LTNA),highpressure mercury intrusion(HPMI),and X-ray diffraction(XRD)were used to analyze and compare samples from two wells located in different deposition locations.The unconventional Well BYY2 and BX7 s were drilled in the depocenter and distal area of the Qianjiang Formation,respectively.Controlled by differences in the organic matter type and sedimentary environment,the organic matter in Well BYY2,which was found to be characterized by laminar shale,mainly originated from aquatic algae.The results showed that as the total organic carbon(TOC)content increased,the amount of shaleoil in the pores increased.Shale-oil was mostly stored in mesopores and macropores that had been preserved by dolomite minerals of a biogenic origin and also occurred in pores sized 5–200 nm and>1μm.Dolomite minerals of a biogenic origin and clay minerals contributed to the occurrence of shaleoil.In comparison,the organic matter in Well BX7 has been greatly influenced by terrestrial organic matter.Pores in the massive mudstones from Well BX7 were determined to be mainly mesopores preserved by clay minerals and quartz,and the shale-oil was mostly stored within the pores of<40 nm.When the TOC content was~2.5 wt.%,the generated shale-oil reached saturation.Clay minerals contributed to the occurrence of shale-oil,whereas quartz only contributed to the occurrence of shale-oil in macropores. | Zhongliang Sun Zhiliang He Furong Wang Yuanjia Han Sheng He Yuguang Hou Jing Luo Youheng Zheng Shiqiang Wu | 2022 | Journal of Earth Science2022，33，4： | 1 |
| 9 | Robust design of inte- grated feedback and iterative learning control of a batch process based on a 2D Roesser system显示文摘 | Shi Jia Gao Furong Wu Tiejun | 2005 | Journal of Process Control2005，15，： | 1 |
| 10 | Programmable robotized‘transfer-and-jet’printing for large,3D curved electronics on complex surfaces显示文摘Large,3D curved electronics are a trend of the microelectronic industry due to their unique ability to conformally coexist with complex surfaces while retaining the electronic functions of 2D planar integrated circuit technologies.However,these curved electronics present great challenges to the fabrication processes.Here,we propose a reconfigurable,mask-free,conformal fabrication strategy with a robot-like system,called robotized‘transfer-and-jet’printing,to assemble diverse electronic devices on complex surfaces.This novel method is a ground-breaking advance with the unique capability to integrate rigid chips,flexible electronics,and conformal circuits on complex surfaces.Critically,each process,including transfer printing,inkjet printing,and plasma treating,are mask-free,digitalized,and programmable.The robotization techniques,including measurement,surface reconstruction and localization,and path programming,break through the fundamental constraints of 2D planar microfabrication in the context of geometric shape and size.The transfer printing begins with the laser lift-off of rigid chips or flexible electronics from donor substrates,which are then transferred onto a curved surface via a dexterous robotic palm.Then the robotic electrohydrodynamic printing directly writes submicrometer structures on the curved surface.Their permutation and combination allow versatile conformal microfabrication.Finally,robotized hybrid printing is utilized to successfully fabricate a conformal heater and antenna on a spherical surface and a flexible smart sensing skin on a winged model,where the curved circuit,flexible capacitive and piezoelectric sensor arrays,and rigid digital–analog conversion chips are assembled.Robotized hybrid printing is an innovative printing technology,enabling additive,noncontact and digital microfabrication for 3D curved electronics. | YongAn Huang Hao Wu Chen Zhu Wennan Xiong Furong Chen Lin Xiao Jianpeng Liu Kaixin Wang Huayang Li Dong Ye Yongqing Duan Jiankui Chen Hua Yang Wenlong Li Kun Bai Zhouping Yin Han Ding | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 1 |
| 11 | The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP显示文摘Dear Editor,Chemoresistance is a major problem in the treatment of ovarian cancer patients and leads to poor prognosis,but its underlying mechanism remains elusive.Accumulating evidences have found that the aberrant regulation of the protein ubiquitination pathway plays an essential role in ovarian cancer chemoresistance.13 However,it is unclear whether and how deubiquitinase-USP11 involves in ovarian cancer chemoresistance. | Xiaolin Zhu Yiping Zhang Qingyu Luo Xiaowei Wu Furong Huang Tong Shu Yong Wan Hongyan Chen Zhihua Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 12 | Design of dynamic matrix control based PID for residual oil outlet tempera- ture in a coke furnace 显示文摘 | Wu Sheng Zhang Ri -dong Lu Ren -quan Gao Furong | 2014 | Chemometrics and Intelligent Laborato- ry Systems2014，134，： | 1 |
| 13 | Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2显示文摘The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the epidemic.Therefore,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic targets.Here,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and ubiquitinomic.Multiomics analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory responses.Ubiquitinomic further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune response.In addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral infection.Further screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral targets.This multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets. | Gang Xu Yezi Wu Tongyang Xiao Furong Qi Lujie Fan Shengyuan Zhang Jian Zhou Yanhua He Xiang Gao Hongxiang Zeng Yunfei Li Zheng Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 14 | Preparation of graphene by exfoliation of graphite using wet ball milling 显示文摘 | Zhao Weifeng Fang Ming Wu Furong | 2010 | J Mater Chem2010，20，： | 1 |
| 15 | Reliability-based distribution network pricing显示文摘 | Gu Chenghong Wu Jianzhong Li Furong | 2012 | IEEE Trans on Power Sys- tems2012，27，3： | 1 |
| 16 | Local stress field inverted for a shale gas play based on focal mechanisms determined from the joint source scanning algorithm显示文摘The joint source scanning algorithm(SSA)scans locations and focal mechanisms of microseismic events simultaneously.Compared to the traditional source scanning algorithm,it yields much more events with extra information of focal mechanisms.The availability of more events and focal mechanisms make it possible to invert for a 2D gridded stress field.As a byproduct of hydrofracturing monitoring,the method offers a new way to extract stress field as a substitute to other more expensive technologies.This method is applied to a hydraulic fracturing dataset collected from one shale gas production field in the southeast of the Sichuan basin.A damped stress inversion is conducted to obtain a 2D stress field.five hydraulic-fracturing induced fractures can be determined from the result.The events associated with these fractures generally have relatively low stacked energy and are limited to the depth of horizontal well.One existing fault(possibly associated with the axis of the central Sichuan uplift)is also determined and the events associated with the existing fault generally have higher stacked energy and are more densely populated.The existing fault may also serve as a structural boundary where the rocks to the NW side are easier to be fractured while events on the other side are sparse with low stacked energy.The existing fault also divides the stress field into two regimes:the maximum compressional stress field to the NW and SE of the fault line are dominantly in NW-SE and N-S directions,respectively. | Chuntao Liang Yangyang Yu Furong Wu Liang Kang Jian Tang | 2021 | Earthquake Science2021，34，3： | 1 |
| 17 | Exposures to PM 2.5 components and heart rate variability in taxi drivers around the Beijing 2008 Olympic Games显示文摘 | Shaowei Wu Furong Deng Jie Niu Qinsheng Huang Youcheng Liu Xinbiao Guo | 2011 | Science of the Total Environment2011，，13： | 1 |
| 18 | Predictive control optimization based PID control for temperature in an industrial surfactant reactor显示文摘 | Ridong Zhang Sheng Wu Renquan Lu Furong Gao | 2014 | Chemometrics and Intelligent Laboratory Systems2014，，： | 1 |
| 19 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 20 | Improved PI controller based on predictive functional control for liquid level regula- tion in a coke fractionation tower显示文摘 | Ridong Zhang Sheng Wu Furong Gao | 2014 | Joumal of Process Control2014，，24： | 1 |
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