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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Phase I study of an anti-CD30 Fc engineered humanized monoclonal antibody in Hodgkin lymphoma (HL) or anaplastic large cell lymphoma (ALCL) patients:safety,pharmacokinetics (PK),immunogenicity,and efficacy显示文摘 | Blum K A Smith M Fung H | 2009 | J Clin Oncol2009，27，15： | 1 |
| 3 | Nutrient bud- gets in intensive shrimp ponds:implications for sustainability显示文摘 | Simon J Funge Smith Matthew R P Briggs | 1998 | Aquaculture1998，164，： | 1 |
| 4 | Nutrient buintnsive shrimp ponds:implica-tions for sustainability显示文摘 | Funge Smith Brigs M R P | 1998 | Aquaculture1998，164，18： | 1 |
| 5 | The synthesis of oligonucleotides containing an aliphatic amino group at the 5'terminus:synthesis of fluorescent DNA primers for use in DNA sequence analysis显示文摘 | SMITH L M FUNG S HUNKAPILLER M W | 1985 | Nucleic Acids Res1985，13，： | 1 |
| 6 | MeSA and MeJA increase steady-state transcript levels of alternative oxidase and resistance against chilling injury in sweet peppers (Capsicum annuum)显示文摘 | FUNG R W M WANG C Y SMITH D L | 2004 | Plant Science2004，166，： | 1 |
| 7 | Characterization of Ahemative Oxidase (AOX) Gene Expression in Response to Methyl Salicylate and Methyl Jasmonate Pre-treatment and Low Temperature in Tomatoes 显示文摘 | FUNG R W WANG C SMITH D L | 2006 | J Plant Physiol2006，163，10： | 1 |
| 8 | Urgent revascularization of liver allografts after early hepatic artery thrombosis显示文摘 | Pinna AD Smith CV Furukawa H Starzl TE Fung JJ | | 0，，： | 1 |
| 9 | The synthesis of oligonucleotides containing an aliphatic amino group at the 5'terminus: synthesis of fluorescent DNA primers fbr use in DNA sequence analysis显示文摘 | Smith L M Fung S Hunkapiller M W | 1985 | Nucleic Acids Res1985，13，7： | 1 |
| 10 | Nutrient budgets in intensive shrimp ponds:implications for sustainability显示文摘 | Simon J Funge Smith Matthew R P Briggs | 1998 | Aquaculture1998，164，： | 1 |
| 11 | A nutrient budgets of some intensive marine shrimp culture ponds in Thailand 显示文摘 | Briggs M R P Funge - Smith S J | 1994 | Aquacuh Fish Manag1994，25，： | 1 |
| 12 | Implementing a point of care testing (POCT) service improves management of haemostatic dysfunction in cardiac surgery patients显示文摘 | B. Pearse D. Wall I. Smith D. Faulke I. Rapchuck J. Fraser J. McGree L. Drake P. Tesar Yl. Fung | 2014 | Australian Critical Care2014，，1： | 1 |
| 13 | Nutrient budgets in in tensive shrimp ponds :implications for sustainability显示文摘 | Funge Smith S J Briggs M R P | 1998 | Aquaculture1998，164，： | 1 |
| 14 | Clinical/Scientific notes显示文摘 | Dale RC Grattan J Smith P Fung VS | 2011 | Neurology2011，77，14： | 1 |
| 15 | The synthe- sis of oligonucleotides containing an aliphatic amino group at the 5 ' terminus : synthesis of fluorescent DNA primers for use in DNA se- quence analysis显示文摘 | SMITH L M FUNG S HUNKAPILLER M W | 1985 | Nucleic Acids Res1985，13，7： | 1 |
| 16 | A long-term follow-up report on allogeneic stem cell transplantation for patients with primary refractory acute myelogenous leukemia: impact of cytogenetic characteristics on transplantation outcome显示文摘 | H.C Fung A Stein M.L Slovak M.R O'Donnell D.S Snyder S Cohen D Smith A Krishnan R Spielberger R Bhatia S Bhatia P Falk A Molina A Nademanee P Parker R Rodriguez J Rosenthal R Sweetman N Kogut F Sahebi L Popplewell N Vora G Somlo K Margolin W Chow E Smith | 2003 | Biology of Blood and Marrow Transplantation2003，，12： | 1 |
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