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| 1 | Interventional treatment for unresectable hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The Barcelona clinic liver cancer classification is the current standard classification system for the clinical management of patients with HCC and suggests that patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization(TACE). Interventional treatments such as TACE, balloon-occluded TACE, drug-eluting bead embolization, radioembolization, and combined therapies including TACE and radiofrequency ablation, continue to evolve, resulting in improved patient prognosis. However, patients with advanced-stage HCC typically receive only chemotherapy with sorafenib, a multi-kinase inhibitor, or palliative and conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidatesfor systemic therapy. However, these patients require therapy that is more effective than sorafenib or conservative treatment. Several researchers try to perform more effective therapies, such as combined therapies(TACE with radiotherapy and sorafenib with TACE), modified TACE for HCC with arterioportal or arteriohepatic vein shunts, TACE based on hepatic hemodynamics, and isolated hepatic perfusion. This review summarizes the published data and data on important ongoing studies concerning interventional treatments for unresectable HCC and discusses the technical improvements in these interventions, particularly for advanced-stage HCC. | Satoru Murata Takahiko Mine Fumie Sugihara Daisuke Yasui Hidenori Yamaguchi Tatsuo Ueda Shiro Onozawa Shin-ichiro Kumita | 2014 | World Journal of Gastroenterology2014，20，37： | 38 |
| 2 | Feasibility of cold snare polypectomy in Japan: A pilot study显示文摘AIM: To investigate the feasibility of cold snare polypectomy(CSP) in Japan.METHODS: The outcomes of 234 non-pedunculated polyps smaller than 10 mm in 61 patients who underwent CSP in a Japanese referral center were retrospectively analyzed. The cold snare polypectomies were performed by nine endoscopists with no prior experience in CSP using an electrosurgical snare without electrocautery.RESULTS: CSPs were completed for 232 of the 234 polyps. Two(0.9%) polyps could not be removed without electrocautery. Immediate postpolypectomy bleeding requiring endoscopic hemostasis occurred in eight lesions(3.4%; 95%CI: 1.1%-5.8%), but all were easily managed. The incidence of immediate bleeding after CSP for small polyps(6-9 mm) was significantly higher than that of diminutive polyps(≤ 5 mm; 15% vs 1%, respectively). Three(5%) patients complained of minor bleeding after the procedure but required no intervention. The incidence of delayed bleeding requiringendoscopic intervention was 0.0%(95%CI: 0.0%-1.7%). In total, 12% of the resected lesions could not be retrieved for pathological examination. Tumor involvement in the lateral margin could not be histologically assessed in 70(40%) lesions.CONCLUSION: CSP is feasible in Japan. However, immediate bleeding, retrieval failure and uncertain assessment of the lateral tumor margin should not be underestimated. Careful endoscopic diagnosis before and evaluation of the tumor residue after CSP are recommended when implementing CSP in Japan. | Yoji Takeuchi Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Kengo Nagai Fumi Matsui Tomofumi Akasaka Noboru Hanaoka Koji Higashino Hiroyasu Iishi Ryu Ishihara Henrik Thorlacius Noriya Uedo | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，17： | 14 |
| 3 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 4 | Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy显示文摘AIM To evaluate the relationship between the location of hepatocellular carcinoma(HCC) and the efficacy of transarterial chemoembolization(TACE).METHODS We evaluated 115 patients(127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to m RECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center(mm)/liver diameter(mm) on multiplanar reconstruction images rendered(MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response(CR) and non-CR groups in Child-Pugh grade A and B patients.RESULTS The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients(0.82 vs 0.62, P < 0.001; 0.71 vs 0.59, P < 0.01; 0.81 vs 0.49, P < 0.05, respectively). However, there was no significant difference in the median location coefficient of the HCC in the lateral segment between in the CR and in the non-CR groups(0.67 vs 0.65, P > 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR groups.CONCLUSION Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients. | Izumi Miki Satoru Murata Fumio Uchiyama Daisuke Yasui Tatsuo Ueda Fumie Sugihara Hidemasa Saito Hidenori Yamaguchi Ryusuke Murakami Chiaki Kawamoto Eiji Uchida Shin-ichiro Kumita | 2017 | World Journal of Gastroenterology2017，23，35： | 8 |
| 5 | 多重稳固的胰腺的 hamartomas : 一份案例报告和文学的评论显示文摘 Non-neoplastic tumor-like lesions in the pancreas are uncommon.Here,we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman.Her computed tomography revealed a pancreatic mass,measuring 1.8 cm in maximum diameter.However,no symptoms were found.She was not an alcoholic and had no history of pancreatitis.The patient underwent a pancreatoduodenectomy,and three well-demarcated solid nodules measuring 1.7 cm,0.4 cm,and 0.3 cm in diameter were found in the pancreatic head.Microscopically,the lesions were composed of non-neoplastic,disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets.The stromal spindle cells were immunoreactive for CD34 and CD117.The histological diagnosis was multiple solid hamartomas of the pancreas.There has been no recurrence 30 mo after surgery.So far,18 cases of pancreatic hamartoma have been reported in the English literature,including our case.Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma.Although the number of cases was limited,solid pancreatic hamartomas seem to be benign tumor-like lesions,which are found incidentally in healthy middle-aged adults,but occasionally involve the whole pancreas,resulting in a poor prognosis.Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality,and multiple small lesions other than the main tumors were detected in a small number of cases.From these findings,one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas. | Fumi Kawakami Michio Shimizu Hiroshi Yamaguchi Shigeo Hara Ippei Matsumoto Yonson Ku Tomoo Itoh | 2012 | World Journal of Gastrointestinal Oncology2012，4，9： | 5 |
| 6 | The inner solar system cratering record and the evolution of impactor populations显示文摘We review previously published and newly obtained crater size-frequency distributions in the inner solar system. These data indicate that the Moon and the terrestrial planets have been bombarded by two populations of objects. Population 1,dominating at early times, had nearly the same size distribution as the present-day asteroid belt, and produced heavily cratered surfaces with a complex, multi-sloped crater size-frequency distribution. Population 2, dominating since about 3.8–3.7 Gyr,had the same size distribution as near-Earth objects(NEOs) and a much lower impact flux, and produced a crater size distribution characterized by a differential –3single-slope power law in the crater diameter range 0.02 km to 100 km. Taken together with the results from a large body of work on age-dating of lunar and meteorite samples and theoretical work in solar system dynamics, a plausible interpretation of these data is as follows. The NEO population is the source of Population 2 and it has been in near-steady state over the past ~ 3.7–3.8 Gyr; these objects are derived from the main asteroid belt by size-dependent non-gravitational effects that favor the ejection of smaller asteroids. However, Population 1 was composed of main belt asteroids ejected from their source region in a size-independent manner, possibly by means of gravitational resonance sweeping during orbit migration of giant planets;this caused the so-called Late Heavy Bombardment(LHB). The LHB began some time before ~3.9 Gyr, peaked and declined rapidly over the next ~ 100 to 300 Myr,and possibly more slowly from about 3.8–3.7 Gyr to ~2 Gyr. A third crater population(Population S) consisted of secondary impact craters that can dominate the cratering record at small diameters. | Robert G.Strom Renu Malhotra Zhi-Yong Xiao Takashi Ito Fumi Yoshida Lillian R Ostrach | 2015 | Research in Astronomy and Astrophysics2015，15，3： | 3 |
| 7 | Laparoscopic Kasai portoenterostomy can be a standard surgical procedure for treatment of biliary atresia显示文摘BACKGROUND Biliary atresia(BA)is a rare pediatric disease.AIM To compare the outcomes of laparoscopic portoenterostomy(Lap-PE)with those of laparotomy(Open-PE)at a single institution.METHODS The surgical outcomes of PE were retrospectively analyzed for patients with a non-correctable type of BA from 2003 to 2020.RESULTS Throughout the assessment period,119 patients received PE for BA treatment,including 66 Open-PE and 53 Lap-PE cases.Although the operation duration was longer(medians:for Open-PE,242 min;for Lap-PE,341 min;P<0.001),blood loss was considerably less(medians:for Open-PE,52 mL;for Lap-PE,24 mL;P<0.001)in the Lap-PE group than in the Open-PE group.The postoperative recovery of the Lap-PE group was more favorable;specifically,both times to resume oral intake and drain removal were significantly shorter in the Lap-PE group.Complete resolution of jaundice was observed in 45 Open-PE cases and 42 Lap-PE cases,with no statistically significant difference(P=0.176).Native liver survival rates were>80%for both groups for the first half year post surgery,followed by a gradual decrease with time;there were no statistically significant differences in the native liver survival rates for any durations assessed.CONCLUSION Lap-PE could be a standard therapy for BA. | Chiyoe Shirota Akinari Hinoki Takahisa Tainaka Wataru Sumida Fumie Kinoshita Kazuki Yokota Satoshi Makita Hizuru Amano Yoichi Nakagawa Hiroo Uchida | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 2 |
| 8 | GSK-3β regulates cyclin D1 expression: A new target for chemotherapy显示文摘 | Fumi Takahashi-Yanaga Toshiyuki Sasaguri | 2007 | Cellular Signalling2007，，4： | 2 |
| 9 | Hepatocellular carcinoma with nonalcoholic steatohepatitis显示文摘 | Sayaka Mori Takahiro Yamasaki Isao Sakaida Taro Takami Eiki Sakaguchi Teruaki Kimura Fumie Kurokawa Shiro Maeyama Kiwamu Okita | 2004 | Journal of Gastroenterology2004，，4： | 2 |
| 10 | Adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery显示文摘这份报告由帮助 laparoscopic 的外科描述脐肠系膜包囊 resected 的一个极其稀罕的成年案例。A 29-years-old 日语人被提交并且因为一个腹的团和提高的浆液 CEA (carcinoembryonic 抗原) ,承认了到九州大学医院在 2001 年 8 月的水平(21.3 ng/mL ) 。腹的 CT 和美国与中隔和石灰化表明了一个膀胱的团。腹腔镜检查显示了一个大团被纳入他的腹壁,测量 110 公里 x 70 公里 x 50 公里并且充满了粘液。团是由帮助 laparoscopic 的外科的 resected。它的墙的组织检查所见显示出纤维肌性织物,脂肪组织,石灰化,和肠的结构。是脐肠系膜包囊最后被诊断。 | Fumi Sawada Rie Yoshimura Kenichi Ito Kazuhiko Nakamura Hajime Nawata Kazuhiro Mizumoto Shuji Shimizu Takahiro Inoue Takashi Yao Masazumi Tsuneyoshi Atushi Kondo Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 11 | Quantitative index calculated by ^(99m)Tc-GSA scintigraphy显示文摘99mTc-galactosyl human serum albumin(GSA) scintigraphy is useful to evaluate hepatic function and hepatic functional reserve. A reliable SPECT and CT integrated system is now commercially available. Using this system, we can obtain 99mTc-GSA SPECT/CT fused imaging with a small registration error. Therefore, the 99mTc-GSA scintigraphy techniques prove more useful in clinical practice than have been previously reported. In the latest Annals of Surgical Oncology on Oct 2014, the uptake index(UI) values calculated from 99mTc-GSA scintigraphy are reported to be useful for predicting the functional reserve of the future remnant liver. In this paper, we describe the usefulness of 99mTc-GSA scintigraphy as well as some cautions that are necessary as regards using the system. | Morikatsu Yoshida Shinya Shiraishi Noriko Tsuda Fumi Sakamoto Seiji Tomiguchi Yasuyuki Yamashita | 2014 | Chinese Journal of Cancer Research2014，26，6： | 2 |
| 12 | Novel zinc alloys for biodegradable surgical staples显示文摘BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical staples.AIM To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy staples.METHODS Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk post-operation.RESULTS Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respectively, in Fe SSIF. These degradation times are sufficient for wound healing. The degradation rate is notably increased under low pH conditions. Scanning electron microscopy and energy dispersive spectrometry surface analyses of the staples after immersion indicated that the component elements eluted as ions in Fe SSIF, whereas corrosion products were produced in HBSS, inhibiting Zn dissolution. In the animal study, none of the Zn alloy staples caused technical failure, and all rabbits survived without complications. Histopathological analysis revealed no severe inflammatory reaction around the Zn alloy staples.CONCLUSION Staples made of Zn-1.0Cu-0.2Mn-0.1Ti, Zn-1.0Mn-0.1Ti, and Zn-1.0Cu-0.1Ti exhibit acceptable in vitro mechanical properties, proper degradation behavior,and in vivo safety and feasibility. They are promising candidates for biodegradable staples. | Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 13 | Etiology and clinical study of community-acquired pneumonia in 157 hospitalized children显示文摘 | Takeshi Tajima Eiichi Nakayama Yasuo Kondo Fumie Hirai Hiroaki Ito Taketoshi Iitsuka Mei Momomura Hirokazu Kutsuma Yuri Kodaka Naomi Funaki Yukishige Yanagawa Kimiko Ubukata | 2006 | Journal of Infection and Chemotherapy2006，，6： | 2 |
| 14 | Isoflavone Regulates Lipid Metabolism via Expression of Related Genes in OVX Rats Fed on a High-fat Diet显示文摘Objective To investigate the effects of isoflavone on body weight,fat mass,and gene expression in relation to lipid metabolism.Methods Thirty-six female SD rats were ovariectomized or sham-operated and fed on a high-fat diet.Two months later,abdominal incision was made,blood was collected to separate serum,and the liver and adipose tissue were immediately collected and weighed.Some portions of these tissues were frozen in liquid nitrogen and stored at -80℃.Results Ovariectomy(OVX) with a high-fat diet could induce obesity in rats,while treatment with isoflavone significantly inhibited the increase in body weight and fat mass in abdomen.Serum total cholesterol and leptin were significantly decreased in isoflavone group,compared with the OVX group.The mRNA expression of liver fatty acid synthase(FAS) in the OVX group was significantly higher than that in sham-operated group,while this difference was not observed in the isoflavone group.The mRNA expression of liver hormone-sensitive lipase(HSL) in the OVX rats tended to be lower than that in the sham-operated rats.Furthermore,a large amount of isoflavone maintained the mRNA expression at a sham level.Conclusion Isoflavone may prevent obesity induced by ovariectomy with a high-fat diet,in part by modulating gene expression related to lipid metabolism. | XIAO-LIN NA JUNKO EZAKI FUMIE SUGIYAMA HONG-BIN CUI AND YOSHIKO ISHIMI | 2008 | Biomedical and Environmental Sciences2008，21，5： | 2 |
| 15 | Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue显示文摘 | Tsuyoshi T Takeomi T Fumi N | 1999 | J Neuro-Oncol1999，44，1： | 1 |
| 16 | Therapeutic effect of il-12/ 23 and their signaling pathway blockade on brain ischemia model 显示文摘 | Fumie K Takashi S Hideyuki Y | 2010 | Biochem Biophys Res Commun2010，402，3： | 1 |
| 17 | Plasma pentraxin 3 levels are associated with carotid IMT in type 1 diabetic patients显示文摘 | Naoto Katakami Hideaki Kaneto Fumie Sakamoto | 2013 | Diabetes Research and Clinical Practice2013，99，2： | 1 |
| 18 | Relationship between the proliferative capability of hepatocytes andthe intrahepatic expression of hepatocyte growth factor and c-Met in the courseof cirrhosis development in rats显示文摘 | Hideyuki Inoue Fumi Yokoyama Yuko Kita Hitoshi Yoshiji Tatsuhiro Tsujimoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Naohito Uchida Tsutomu Masaki Seishiro Watanabe Shigeki Kuriyama | 2006 | International Journal of Molecular Medicine2006，，5： | 1 |
| 19 | Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10显示文摘 | Daisuke Watanabe Fumi Goshima Isamu Mori Yasuhiko Tamada Yoshinari Matsumoto Yukihiro Nishiyama | 2007 | Journal of Dermatological Science2007，，3： | 1 |
| 20 | Pilot Study of Oncolytic Viral Therapy Using Mutant Herpes Simplex Virus (HF10) Against Recurrent Metastatic Breast Cancer显示文摘 | Hideto Kimata MD PhD Tsuneo Imai MD PhD Toyone Kikumori MD PhD Osamu Teshigahara MD PhD Tetsuro Nagasaka MD PhD Fumi Goshima MD PhD Yukihiro Nishiyama MD PhD Akimasa Nakao MD PhD | 2006 | Annals of Surgical Oncology2006，，8： | 1 |
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