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| 1 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 2 | A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma显示文摘AIM: To summarize the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thora- coscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC). METHODS: Time-lag performance of RFA after ethanol injection (Time-lag PEI-RFA) was performed in all cases. The volume of coagulated necrosis and the applied en- ergy for total and per unit volume coagulated necrosis were examined in the groups treated under general (group G) or local anesthesia (group L). RESULTS: The results showed that the total applied energy and the applied energy per unit volume of whole and marginal, coagulated necrosis were significantly larger in group G than those in the group L, resulting in a larger volume of coagulated necrosis in the group G. The rate of local tumor recurrence within one year was extremely low in group G. CONCLUSION: These results suggest that EI-RFA, un- der general anesthesia, may be effective for the treat- ment of HCC because a larger quantity of ethanol and energy could be applied during treatment under pain- free condition for the patients. | Kazutaka Kurokohchi Seishiro Watanabe Hirohito Yoneyama Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hisaaki Miyoshi Hamdy Saad Mohammad Akira Kitanaka Tomohiko Taminato Shigeki Kuriyama | 2008 | World Journal of Gastroenterology2008，14，13： | 10 |
| 3 | Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas显示文摘BACKGROUND: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, and angiogenesis and induce apoptosis. We examined maspin expression immunohistochemically and assessed its significance in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. METHODS: We examined 39 surgically resected specimens of IPMN that included 17 adenomas (IPMAs), 5 borderline tumors (IPMBs), 4 non-invasive carcinomas (non-invasive IPMCs), and 13 invasive carcinomas (invasive IPMCs). Immunostaining was performed according to the EnVision ChemMate method. The degree of maspin expression was scored and assessed according to the percentage and staining intensity of positive cells. RESULTS: Maspin expression was minimal in normal pancreatic duct epithelium, whereas in IPMNs, maspin was expressed in neoplasms of all stages. Maspin expression increased with increasing grade from IPMAs, IPMBs, to non-invasive IPMCs but decreased significantly in invasive IPMCs. No specific association between maspin expression and mucin type was found. Analysis of maspin expression with respect to clinicopathologic factors in cases of invasive IPMC revealed a greater extent of invasion in cases of low maspin expression and significantly fewer apoptotic cells in the tumor.CONCLUSIONS: Maspin was expressed at high levels in IPMNs at various stages from adenoma to invasive carcinoma, and our results suggest that maspin may be involved in the occurrence and progression of IPMN. In addition, our data suggest that the apoptosis-inducing action of maspin suppresses invasion and progression of IPMN. | Kyoko Kashima Nobuyuki Ohike Seishiro Mukai Masashi Sato Manabu Takahashi Toshio Morohoshi | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 9 |
| 4 | Nonlinear Vibration Induced by the Water-film Whirl and Whip in a Sliding Bearing Rotor System显示文摘Many industrial applications and experiments have shown that sliding bearings often experience fluid film whip due to nonlinear fluid film forces which can cause rotor-stator rub-impact failures. The oil-film whips have attracted many studies while the water-film whips in the water lubricated sliding bearing have been little researched with the mechanism still an open problem. The dynamic fluid film forces in a water sliding bearing are investigated numerically with rotational, whirling and squeezing motions of the journal using a nonlinear model to identify the relationships between the three motions. Rotor speed-up and slow-down experiments are then conducted with the rotor system supported by a water lubricated sliding bearing to induce the water-film whirl/whip and verify the relationship. The experimental results show that the vibrations of the journal alternated between increasing and decreasing rather than continuously increasing as the rotational speed increased to twice the first critical speed, which can be explained well by the nonlinear model. The radial growth rate of the whirl motion greatly affects the whirl frequency of the journal and is responsible for the frequency lock in the water-film whip. Further analysis shows that increasing the lubricating water flow rate changes the water-film whirl/whip characteristics, reduces the first critical speed, advances the time when significant water-film whirling motion occurs, and also increases the vibration amplitude at the bearing center which may lead to the rotor-stator rub-impact. The study gives the insight into the water-film whirl and whip in the water lubricated sliding bearing. | ZHAI Liming LUO Yongyao WANG Zhengwei KITAUCHI Seishiro MIYAGAWA Kazuyoshi | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 3 |
| 5 | Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis显示文摘瞄准:尽管位于自体免疫的肝炎(AIH ) 下面的病原的机制仍然保持不清楚,免疫系统被认为为疾病的前进批评。细胞的有免疫力的回答可以在 AIH 被连接到肝细胞损坏。最近,许多注意集中于在有效 T 调停房间的有免疫力的回答的产生在单音的原子房间上表示的 costimulatory 分子的批评功能。与 AIH 从病人在单音的原子房间上表示的 costimulatory 分子的分析可以在 AIH 给我们卓见进肝细胞损坏的病原的机制。方法:单音的原子房间(PBMC ) 与 AIH (34 个盒子) 和健康控制(25 个盒子) 从病人被拿的外部血。渗透的单音的原子房间(LIMC ) 与 AIH (18 个盒子) 从病人被拿的肝,有长期的丙肝(CH-C )(13 个盒子) 的病人和有脂肝(2 个盒子) 的病人。用流动血细胞计数,房间为 costimulatory 分子的表示被分析,例如 CD80, CD86,和 CD152 (CTLA-4 ) 。结果与象到 corticosteroids 的 corticosteroids 管理和反应的 gammaglobulin,组织学的等级,存在或缺席的水平那样的临床的数据相比。结果:CD80+ , CD86+ 和 CD152+ PBMC 的层次显著地作为与健康控制相比与 AIH 在病人被减少。由对比,那些房间比在有 AIH 的病人的 PBMC 在 LIMC 是显著地更高的。特别,不管疾病活动的度, CD86+ LIMC 的水平与 AIH 在病人显示出显著增加,尽管 CD86+ 房间是很少在 PBMC 在场。CD86+ 房间的层次显著地是在场的在里面在有 AIH 的病人的高频率比在有 CH-C 的病人。而且,有有 CD86+ LIMC 的高水平的 AIH 的病人显示出好回答到 corticosteroids,而有 CD86+ LIMC 的底层的 AIH 的 2 个盒子没反应很好。结论:这些结果建议那 LIMC 过去表示的 costimulatory 分子象 CD80 和 CD86 那样看起来在 AIH 的致病起一个作用。特别,在 LIMC 上表示的 CD86 分子可能为 AIH 的诊断并且为 AIH 上的 corticosteroids 的治疗学的效果的预言是有用的。 | Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko Kimura Seishiro Watanabe Shigeki Kuriyama | 2006 | World Journal of Gastroenterology2006，12，16： | 2 |
| 6 | Percutaneous local therapies for hepatocellular carcinoma impair gastric function显示文摘TO THE EDITORPercutaneous local therapies,such as percutaneous ethanolinjection(PEI),microwave coagulation and radiofrequencyablation(RFA),are frequently used world,vide for thetreatment of hepatocellular carcinoma(HCC)becauseof their high effectiveness.Although these treatmentmodalities can induce effectively coagulated tumornecrosis in the liver,they may cause adverse effects onextrahepatic abdominal organs.There are,however。 | Fumihiko Kinekawa Kazuya Matsuda Tsutomu Masaki Kazutaka Kurokohchi Hirohito Yoneyama Hideyuki Inoue Hirohide Kurata Yoshihito Uchida Seishiro Watanabe Shigeki Kuriyama | 2006 | World Journal of Gastroenterology2006，12，1： | 2 |
| 7 | Relationship between the proliferative capability of hepatocytes andthe intrahepatic expression of hepatocyte growth factor and c-Met in the courseof cirrhosis development in rats显示文摘 | Hideyuki Inoue Fumi Yokoyama Yuko Kita Hitoshi Yoshiji Tatsuhiro Tsujimoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Naohito Uchida Tsutomu Masaki Seishiro Watanabe Shigeki Kuriyama | 2006 | International Journal of Molecular Medicine2006，，5： | 1 |
| 8 | Nanoparticles in Emissions and Atmospheric Environment: Now and Future显示文摘 | Seishiro Hirano Hiroshi Nitta Yuichi Moriguchi Shinji Kobayashi Yoshinori Kondo Kiyoshi Tanabe Takahiro Kobayashi Shinji Wakamatsu Masatoshi Morita Satoshi Yamazaki | 2003 | Journal of Nanoparticle Research (-)2003，，3： | 1 |
| 9 | Computational study on the formation of five-membered rings in pah through reaction with O 2显示文摘 | N??lson Kunioshi Minoru Touda Seishiro Fukutani | 2002 | Combustion and Flame2002，，3： | 1 |
| 10 | Low-temperature synthesis of nanometer-sized crystalling Ti O2particals and their photoinduced decomposition of formic acid显示文摘 | Seishiro Ito Shigeto Inoue Hiromi Kawada | 1999 | Journal of Colloid and Interface Science1999，216，1： | 1 |
| 11 | Conven- ient Preparation o{ 1,2- Cyclohexanediones显示文摘 | MASANORI U SEISHIRO M AKIRA T | 1980 | Chem Lett1980，，7： | 1 |
| 12 | A current overview of health effect research on nanoparticles显示文摘 | Seishiro Hirano | 2009 | Environmental Health and Preventive Medicine2009，，4： | 1 |
| 13 | Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells显示文摘 | Cunnigaipur DA Sanae Kanno Seishiro Hirano | 2001 | Free Radical Biology and Medicine2001，31，3： | 1 |
| 14 | 竹原精炼厂采用大电解槽精炼铅及其机械化显示文摘竹原电解精炼铅厂的扩迠工作已于1969年完成。扩迠计划力图考虑采用大型电解槽,使物料搬运系统机械化和改善产品质量。该厂于1969年开始生产,在过去的四年中,所增加的一些改进措施通过运转令人十分满忌。目前电铅月产量大约3,500吨,不久将扩大其能力两倍以上。由于机械化和采用了大电解槽,节省了劳动力。电铅的质量非常好,含铅达99.999%,铋0.0002%,锑0.0001%,铜0.0001%。 | Seishiro Hirakawa 陈子皋 | 1980 | 中国有色冶金1980，0，7： | 1 |
| 15 | Low-temperature synthesis of nanometer-sized crystalline TiO2 particles and their photoinduced decomposition of formic acid显示文摘 | SEISHIRO I SHIGETO I HIROMI K | 1999 | Journal of Colloid and Interface Science1999，216，： | 1 |
| 16 | Experimental investigation on generated power of amorphous PV module for roof azimuth显示文摘 | Takeharu Yamawaki Seishiro Mizukami Takashi Masui | 2001 | Solar Energy Materials & Solar Cells2001，67，： | 1 |
| 17 | Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells显示文摘 | Xing Cui Toshifumi Wakai Yoshio Shirai Naoyuki Yokoyama Katsuyoshi Hatakeyama Seishiro Hirano | 2006 | Human Pathology2006，，3： | 1 |
| 18 | Fulminant hepatic failure caused by malignant melanoma of unknown primary origin显示文摘 | Misuzu Tanaka Seishiro Watanabe Tsutomu Masaki Kazutaka Kurokohchi Fumihiko Kinekawa Hideyuki Inoue Naohito Uchida Shigeki Kuriyama | 2004 | Journal of Gastroenterology2004，，8： | 1 |
| 19 | H2 generation by cycling dark adsorption and successive photoinduced desorption of 2-mercaptopyridine on/from Ag-core/Pt-shell nanoparticles loaded on TiO2显示文摘 | Tada Hiroaki Teranishi K Ito Seishiro | 2000 | Langmuir2000，15，： | 1 |
| 20 | Metabolism of arsenic and its toxicological relevance显示文摘 | Takayuki W Seishiro H | 2013 | Archives of Toxicology2013，87，6： | 1 |
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