|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HER2 gene status and the relationship with p21 protein expression in gastric cancer显示文摘我们瞄准了到分析的目的有在胃的癌的 p21 蛋白质表示的 HER2 基因地位和它的关系。在 situ 杂交(鱼) 和 immunohistochemistry (IHC ) 的方法荧光技术被用来在胃的癌症的 59 种情况中检测 HER2 基因地位和 p53 蛋白质。HER2 基因扩大率的结果鱼察觉是 16.9%(10/59 ) ,在没有拷贝数字获得的 49 种情况中的 HER2 基因扩大和基因扩大是 49.2% 的一个总数(29/59 ) 。HER2 蛋白质表示是 42.4%(25/59 ) ,在有 +++ 的病人的 HER2 基因扩大率,, ++ HER2 蛋白质表示在有 + HER2 蛋白质表示的病人是 3/3 和 5/8,它是 2/14,有重要差别(P < 0.05 ) 。p21 蛋白质表示率是 49.2%(29/59 ) , HER2 基因扩大率和 p21 蛋白质表示在肿瘤侵略深度有重要差别,淋巴节点转移(P < 0.05 ) ;在组织学的类型的有的不统计的意义,变老,性差别(P > 0.05 ) 。结论 HER2 基因扩大率和基因拷贝数字断然与 p21 蛋白质表示, HER2 基因地位和联合察觉能提供的 p21 蛋白质的表示有关联在胃的癌症转移,病人条件开发和预后的引用值,它能也指导单个治疗的临床的开发。 | Yongjie Li Yangkun Wang Xianwei Zhang Fulin Li Nianlong Meng Xutao Yuan Jinsheng Song | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 2 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 3 | MDM 2 is a useful prognostic biomarker for resectable gastric cancer显示文摘 | Yang Ye Xuan Li Jingjing Yang Shuhan Miao Shouyu Wang Yansu Chen Xiaowei Xia Xuming Wu Jianbing Zhang Yan Zhou Song He Yongfei Tan Fulin Qiang Gang Li Oluf Dimitri R?e Jianwei Zhou | 2013 | Cancer Sci2013，，5： | 1 |
| 4 | Aspirin upregulates the expression of neuregulin 1 and survivin afterfocal cerebral ischemia/reperfusion in rats显示文摘 | Fan He Fang Qu Fulin Song | 2012 | Experimental and Therapeutic Medicine2012，，4： | 1 |
| 5 | UBA3 promotes the occurrence and metastasis of intrahepatic cholangiocarcinoma through MAPK signaling pathway显示文摘Intrahepatic cholangiocarcinoma(icC)accounts for approximately 15%of primary liver cancers,and the incidence rate has been increasing in recentyears.Surgical resection is the best treatment for IcC,but the 5-year survival rate is less than 30%.IcC signature genes are crucial for the early diagnosis of IcC,so it is especially important to identify signature genes.The aim of this study is to screen the signature genes of IcC and find the potential target for the treatment of ICC.We find that UBA3 is highly expressed in ICC,and knockdown of UBA3 inhibits ICC proliferation,invasion and migration.Mechanistic experiments show that UBA3 promotes IcC proliferation,invasion and mi-gration by affecting ANXA2 through the MAPK signaling pathway.UBA3 is a target of bufalin,and bufalin targeting UBA3 inhibits ICC development and progression through the MAPK signaling pathway.In conclusion,our study shows that bufalin inhibits IcC by targeting UBA3,which has emerged as a new biomarker and potential therapeutic target forIcc. | Huhu Zhang Jiahua Yang Qinghang Song Xiaoyan Ding Fulin Sun Lina Yang | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 6 | Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia显示文摘The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins. | Haiming Qin Fulin Song Hongguang Han Hong Ou Xingwen Zhai Bin Qin Song You | 2011 | Neural Regeneration Research2011，6，27： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员