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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research显示文摘Alfalfa(Medicago sativa)is one of the most important forage crops in the world;however,its molecular genetics and breeding research are hindered due to the lack of a high-quality reference genome.Here,we report a de novo assembled 816-Mb high-quality,chromosome-level haploid genome sequence for‘Zhongmu No.1’alfalfa,a heterozygous autotetraploid.The contig N50 is 3.92 Mb,and 49165 genes are annotated in the genome.The alfalfa genome is estimated to have diverged from M.truncatula approximately 8 million years ago.Genomic population analysis of 162 alfalfa accessions revealed high genetic diversity,weak population structure,and extensive gene flow from wild to cultivated alfalfa.Genome-wide association studies identified many candidate genes associated with important agronomic traits.Furthermore,we showed that MsFTa2,a Flowering Locus T homolog,whose expression is upregulated in salt-resistant germplasms,may be associated with fall dormancy and salt resistance.Taken together,these genomic resources will facilitate alfalfa genetic research and agronomic improvement. | Chen Shen Huilong Du Zhuo Chen Hongwei Lu Fugui Zhu Hong Chen Xiangzhao Meng Qianwen Liu Peng Liu Lihua Zheng Xiuxiu Li Jiangli Dong Chengzhi Liang Tao Wang | 2020 | Molecular Plant2020，13，9： | 21 |
| 3 | Type Synthesis of 4-DOF Parallel Kinematic Mechanisms Based on Grassmann Line Geometry and Atlas Method显示文摘Many methods are proposed to deal with the type synthesis of parallel kinematic mechanisms(PKMs),but most of them are less intuitive to some extent.Thus,to propose a concise and intuitive type synthesis method for engineering application is a very challenging issue,which should be further studied in the field.Grassmann line geometry,which can investigate the dimensions of spatial line-clusters in a concise way,is taken as the mathematic foundation.Atlas method is introduced to visually describe the degrees of freedom(DOFs)and constraints of a mechanism,and the dual rule is brought in to realize the mutual conversion of the freedom-space and constraint-space.Consequently,a systematic method based on Grassmann line geometry and Atlas method is generated and the entire type synthesis process is presented.Three type 4-DOF PKMs,i.e.,1T3R,2T2R and 3T1R(T:translational DOF;R:rotational DOF),are classified according to the different combinations of the translational DOFs and rotational DOFs.The type synthesis of4-DOF PKMs is carried out and the possible configurations are thoroughly investigated.Some new PKMs with useful functions are generated during this procedure.The type synthesis method based on Grassmann line geometry and Atlas method is intuitive and concise,and can reduce the complexity of the PKMs’type synthesis.Moreover,this method can provide theoretical guidance for other PKMs’type synthesis and engineering application.A novel type synthesis method is proposed,which solves the existing methods’problems in terms of complicated,not intuitive and unsuitable for practical application. | XIE Fugui LI Tiemin LIU Xinjun | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 21 |
| 4 | Error Modeling and Sensitivity Analysis of a Parallel Robot with SCARA(Selective Compliance Assembly Robot Arm) Motions显示文摘Parallel robots with SCARA(selective compliance assembly robot arm) motions are utilized widely in the field of high speed pick-and-place manipulation. Error modeling for these robots generally simplifies the parallelogram structures included by the robots as a link. As the established error model fails to reflect the error feature of the parallelogram structures, the effect of accuracy design and kinematic calibration based on the error model come to be undermined. An error modeling methodology is proposed to establish an error model of parallel robots with parallelogram structures. The error model can embody the geometric errors of all joints, including the joints of parallelogram structures. Thus it can contain more exhaustively the factors that reduce the accuracy of the robot. Based on the error model and some sensitivity indices defined in the sense of statistics, sensitivity analysis is carried out. Accordingly, some atlases are depicted to express each geometric error's influence on the moving platform's pose errors. From these atlases, the geometric errors that have greater impact on the accuracy of the moving platform are identified, and some sensitive areas where the pose errors of the moving platform are extremely sensitive to the geometric errors are also figured out. By taking into account the error factors which are generally neglected in all existing modeling methods, the proposed modeling method can thoroughly disclose the process of error transmission and enhance the efficacy of accuracy design and calibration. | CHEN Yuzhen XIE Fugui LIU Xinjun ZHOU Yanhua | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 17 |
| 5 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 6 | Optimal Design of a Main Driving Mechanism for Servo Punch Press Based on Performance Atlases显示文摘The servomotor drive turret punch press is attracting more attentions and being developed more intensively due to the advantages of high speed,high accuracy,high flexibility,high productivity,low noise,cleaning and energy saving.To effectively improve the performance and lower the cost,it is necessary to develop new mechanisms and establish corresponding optimal design method with uniform performance indices.A new patented main driving mechanism and a new optimal design method are proposed.In the optimal design,the performance indices,i.e.,the local motion/force transmission indices ITI,OTI,good transmission workspace good transmission workspace(GTW) and the global transmission indices GTIs are defined.The non-dimensional normalization method is used to get all feasible solutions in dimensional synthesis.Thereafter,the performance atlases,which can present all possible design solutions,are depicted.As a result,the feasible solution of the mechanism with good motion/force transmission performance is obtained.And the solution can be flexibly adjusted by designer according to the practical design requirements.The proposed mechanism is original,and the presented design method provides a feasible solution to the optimal design of the main driving mechanism for servo punch press. | ZHOU Yanhua XIE Fugui LIU Xinjun | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 7 |
| 7 | Analysis of the kinematic characteristics of a high-speed parallel robot with Sch6nflies motion: Mobility, kinematics, and singularity显示文摘 | Fugui XIE Xin-Jun LIU | 2016 | Frontiers of Mechanical Engineering2016，11，2： | 6 |
| 8 | Conceptual design and kinematic analysis of a novel parallel robot for high-speed pick-and-place operations显示文摘 | Qizhi MENG Fugui XIE Xin-Jun LIU | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 6 |
| 9 | Design and experimental study of the SPKM165, a five-axis serial-parallel kinematic milling machine显示文摘A five-axis serial-parallel kinematic milling machine, the SPKM 165, is introduced. This machine consists of a three-degree of-freedom parallel module and a two-degree-of-freedom serial table. The SPKM 165 is capable of five-face machining. A discussion of the inverse kinematics of the five-axis control is provided. A dimensional synthesis procedure is presented in terms of motion/force transmissibility. Finite-element analysis was used to evaluate the stiffness of a CAD model before the machine was manufactured. Kinematic calibration was implemented to improve the accuracy of the end effector. The results of a calibration experiment are presented. The stiffness of the developed machine was then measured. Milling experiments were conducted, and the test piece showed that the developed machine has satisfactory performance. | XIE FuGui LIU XinJun ZHANG Hui WANG JinSong | 2011 | Science China(Technological Sciences)2011，54，5： | 6 |
| 10 | Proteomic analysis of heterosis in the leaves of sorghum-sudangrass hybrids显示文摘 | Pingan Han Xiaoping Lu Fugui Mi Jing Dong Chunlei Xue Jianke Li Bin Han Xiaoyu Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 5 |
| 11 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 12 | Differences in response of desert plants of different ecotypes to climate warming:a case study in Minqin, Northwest China显示文摘Globally climates are warming.How do desert plants of different ecotypes respond to the climate change?This paper studied the differing responses to climate warming shown by desert plants of different ecotypes through analyzing the phenology and meteorological data of 22 desert plant species growing in Minqin Desert Botanical Garden in Northwest China during the period 1974–2009.The results indicate:(1)The temperature in the study area has risen quickly since 1974,and plants’growing periods became longer.The spring phenology of mesophytes advanced,and the autumn phenology of xerophytes was delayed;(2)The starting dates of spring phenophase of mesophytes and xerophytes differed significantly and both showed an advancing trend;(3)The spring phenology of mesophytes advanced by more days than that of xerophytes,whereas the autumn phenology of mesophytes was delayed by less days than that of the xerophytes;and(4)Mesophytes are more sensitive than xerophytes to rising temperature in spring and falling temperature in autumn.These findings are of value in plant management and regional introduction of different species. | ZhaoFeng CHANG ShuJuan ZHU FuGui HAN ShengNian ZHONG | 2012 | Journal of Arid Land2012，4，2： | 4 |
| 13 | Beclin-1/LC3-II dependent macroautophagy was uninfluenced in ischemia-challenged vascular endothelial cells显示文摘Autophagy has been extensively studied and occurs in many biological settings.However,a question remains as to whether ischemia enhances Beclin-1/LC3-II-dependent macroautophagy in vascular endothelial cells,as has been previously thought.Furthermore,the effect of the level of autophagy on cell or skin flap survival still requires elucidation.We created a lethal ischemia model in human umbilical vascular endothelial cells(HUVECs),performed quantitative proteomics and bioinformatics analyses,and verified the autophagic status and effect both in vitro and in vivo.The significantly upregulated proteins encoded by autophagy-related genes(ATGs)included ATG2A,ATG3,ATG4B,ATG5,ATG7,ATG9A,ATG12,ATG16,and ATG101.The significantly enhanced lysosomal proteins were cathepsin B,cathepsin D,lysosome-associated membrane protein 1(LAMP1),and LAMP2.However,the differentially expressed proteins excluded Beclin-1,microtubule-associated protein light chain 3(LC3)-I,and LC3-II.Western blot analyses verified that the protein expression levels of Beclin-1,LC3-I,and LC3-II were neither upregulated nor downregulated in ischemia-challenged HUVECs.The autophagic status was not enhanced by rapamycin in ischemic HUVECs but appeared to be inhibited by chloroquine.Our in vivo study on rats showed that a downregulation in autophagic status jeopardized skin flap survival.In conclusion,Ischemia neither enhanced nor inhibited Beclin-1/LC3-II-dependent canonical macroautophagy both in vitro and in vivo,in contradiction to previous studies.An appropriate autophagic homeostasis can minimize cell or skin flap damage. | Yaping Ma Chaofan Li Yan He Tiwei Fu Li Song Qingsong Ye Fugui Zhang | 2022 | Genes & Diseases2022，9，2： | 3 |
| 14 | A Study on Some Causes of Rubble Mound Breakwater Failure显示文摘- Rubble mound breakwater, one of the protection structures, has been widely used in coastal and port engineering. Block stones were first used as its armor layer, and its use was limited to shallow sea areas where there is no large waves. Since the specially-shaped armor unit was developed, the rubble mound breakwater has become the main sort of the protection structures, which can be used in deep water zones where storm sometimes occurs. Owing to severe and complex surrounding conditions, the rubble mound breakwater failure sometimes occurs, thus the study on the causes of failure is of great importance. In the present study some breakwater failures at home and abroad are illustrated and the causes of failure are investigated from the point of view of design, test, construction and maintenance. | Zhang Fugui Ge Zhijin Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing 210024 | 1996 | China Ocean Engineering1996，11，4： | 3 |
| 15 | Ecological Environment Conservation and Restoration and Sustainable Development of Minqin Oasis显示文摘Minqin oasis in the lower reaches of the Shiyang River is a main natural barrier for the Wuwei Basin. Due to the combined influence of human activities and natural factors in the past half a century, water quality in the lower reaches of the Shiyang River decreased and ecological environment deteriorated, which influenced sustainable development of this area and surrounding area seriously. This paper analyzed current situation and reasons of the deteriorated ecological environment in the lower reaches of the Shiyang River, and proposed that water environment regulation was the primary task in the eco-environment control of Minqin area, specifically,(a) By using existing policies, accelerating the construction of water-saving agriculture in the middle reaches of the Shiyang River, water quantity in the lower reaches would be guanranted, water shortage for agricultural production and ecological use in Minqin oasis would be relieved;(b) Unreasonable human activities such as overexploitation of underground water should be controlled strictly;(c) Water conservancy project should be developed vigorously to ensure rate of flow. It was expected that the above schemes would contribute to the benign circulation of ecological environment in Minqin oasis. | WANG Lide YAO Tuo XU Feng HAN Fugui GUO Chunxiu WANG Fangling Li Faming | 2016 | Journal of Landscape Research2016，8，1： | 2 |
| 16 | Evaluation of the power consumption of a high-speed parallel robot显示文摘 | Gang HAN Fugui XIE Xin-Jun LIU | 2018 | Frontiers of Mechanical Engineering2018，13，2： | 2 |
| 17 | Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide显示文摘Background: This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter(AGP) on performance, immune status and gut structure after an E. coli lipopolysaccharide(LPS) challenge. Thirty-six pigs were allotted to six treatments including: a non-challenged control(NCC); LPS-challenged control(CC); CC + AGP; CC + yeast extract; CC + enzymes; and CC + enzymes + yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal samples.Results: Overall(d 1 to 11), compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG(P = 0.004),ADFI(P = 0.03) and gain/feed ratio(P = 0.01). At 6 h post-challenge, AGP pigs had lower plasma urea N(PUN; P = 0.02)and serum TNF-α concentration(P = 0.07), and higher platelet count(P = 0.04) and serum IL-10 concentration(P = 0.02) than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN(P = 0.02) than CC pigs, whereas enzymes + yeast extract interacted non-additively(P = 0.001) to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN(P = 0.02)and higher duodenal(P = 0.03), jejunal(P = 0.01) and ileal(P = 0.07) villus height than CC pigs. In addition, enzymes +yeast extract interacted additively and non-additively to reduce ileal IFN-γ(P < 0.0001) and IL-10(P = 0.012) expression,respectively. Generally, no differences(P > 0.10) were observed between AGP and enzymes + yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ(P < 0.0001) and TNF-α(P = 0.003) in enzymes + yeast extract pigs at 96 h post-challenge.Conclusions: The LPS challenged piglets receiving enzymes + yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance. | Samuel M.Waititu Fugui Yin Rob Patterson Juan C.Rodriguez-Lecompte Charles M.Nyachoti | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 1 |
| 18 | Optimum Kinematic Design of the 4R2-DOF Parallel Mechanism显示文摘 | Xie Fugui Liu Xinjun Wang Liping | 2009 | Tsinghua Science and Technology2009，，8： | 1 |
| 19 | Transcriptome analysis reveals genes expression pattern of seed response to heat stress in Brassica napus L.显示文摘Seeds might deteriorate,and lose the ability to germinate when stored under high temperature and high humidity.Brassica napus is one of the most important oil crops in China.However,B.napus seeds were generally stored through summer season with high ambient temperature,which lead to seed viability loss.In order to understand the mechanism of seed response to heat stress and improve seed heat tolerance,B.napus seeds were treated with high temperature(40℃)and ultra-high temperature(60℃)for 4 h.The germination of heatstressed seeds were obviously slower,the germination index and vigor index decreased with temperature increase from 40 to 60℃,and the 40℃ pretreatment could improve the seed tolerance to 60℃ heat stress.Transcriptomics results showed that 442 differentially expressed genes(DEGs)were identified in seeds after heat stress.Gene ontology and KEGG pathway enrichment analysis revealed that some of the genes were involved in posttranslational modification,protein turnover,chaperones and carbohydrate transport,metabolic pathways and secondary metabolites biosynthesis pathway.Among these DEGs,sHSP and transcription factors genes were involved in heat stress tolerance.Thirty-two overlapping genes under different high temperature stress(40℃ and 60℃)were enriched in biological processes of response to oxidative stress and abiotic stimulus.The expression trends of 12 genes randomly selected from the RNA-seq data were almost consistent with the results of qRT-PCR.Our results revealed several potential candidate genes and pathways related to heat responsive by high temperature,which is beneficial for further improving the heat tolerance in B.napus seeds. | Guizhen Gao Jihong Hu Xiaojun Zhang Fugui Zhang Mei Li Xiaoming Wu | 2021 | Oil Crop Science2021，6，2： | 1 |
| 20 | L-fuzzy interiors and L-fuzzy closures 显示文摘 | Shi Fugui | 2009 | Fuzzy Sets and Systems2009，160，9： | 1 |
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