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| 1 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 2 | The westward lithospheric drift,its role on the subduction and transform zones surrounding Americas:Andean to cordilleran orogenic types cyclicity显示文摘We investigate the effect of the westerly rotation of the lithosphere on the active margins that surround the Americas and find good correlations between the inferred easterly-directed mantle counterflow and the main structural grain and kinematics of the Andes and Sandwich arc slabs.In the Andes,the subduction zone is shallow and with low dip,because the mantle flow sustains the slab;the subduction hinge converges relative to the upper plate and generates an uplifting doubly verging orogen.The Sandwich Arc is generated by a westerly-directed SAM(South American) plate subduction where the eastward mantle flow is steepening and retreating the subduction zone.In this context,the slab hinge is retreating relative to the upper plate,generating the backarc basin and a low bathymetry single-verging accretionary prism.In Central America,the Caribbean plate presents a more complex scenario:(a) To the East,the Antilles Arc is generated by westerly directed subduction of the SAM plate,where the eastward mantle flow is steepening and retreating the subduction zone.(b) To the West,the Middle America Trench and Arc are generated by the easterly-directed subduction of the Cocos plate,where the shallow subduction caused by eastward mantle flow in its northern segment gradually steepens to the southern segment as it is infered by the preexisting westerly-directed subduction of the Caribbean Plateau.In the frame of the westerly lithospheric flow,the subduction of a divergent active ridge plays the role of introducing a change in the oceanic/continental plate’s convergence angle,such as in NAM(North American)plate with the collision with the Pacific/Farallon active ridge in the Neogene(Cordilleran orogenic type scenario).The easterly mantle drift sustains strong plate coupling along NAM,showing at Juan de Fuca easterly subducting microplate that the subduction hinge advances relative to the upper plate.This lower/upper plate convergence coupling also applies along strike to the neighbor continental strike slip fault systems where subduction was terminated(San Andreas and Queen Charlotte).The lower/upper plate convergence coupling enables the capture of the continental plate ribbons of Baja California and Yakutat terrane by the Pacific oceanic plate,transporting them along the strike slip fault systems as para-autochthonous terranes.This Cordilleran orogenic type scenario,is also recorded in SAM following the collision with the Aluk/Farallon active ridge in the Paleogene,segmenting SAM margin into the eastwardly subducting Tupac Amaru microplate intercalated between the proto-LiquineOfqui and Atacama strike slip fault systems,where subduction was terminated and para-autochthonous terranes transported.In the Neogene,the convergence of Nazca plate with respect to SAM reinstalls subduction and the present Andean orogenic type scenario. | Eugenio Aragon Fernando D'Eramo Marco Cuffaro Carlo Doglioni Eleonora Ficini Lucio Pinotti Silvina Nacif Manuel Demartis Irene Hernando Tomas Fuentes | 2020 | Geoscience Frontiers2020，11，4： | 2 |
| 3 | Blatella germanica as a possible cockroach vector of micro-organisms in a hospital显示文摘 | G. Risco Oliva C. Díaz O. Fuentes González M.D. Martínez C. Fernández R. Cordoví P. Más Lago N. Herrera | 2009 | Journal of Hospital Infection2009，，1： | 2 |
| 4 | Long-term atmospheric corrosion of mild steel显示文摘 | D. de la Fuente I. Díaz J. Simancas B. Chico M. Morcillo | 2010 | Corrosion Science2010，，2： | 2 |
| 5 | Effect of β-casomorphins and analogs on insulin release in dogs显示文摘 | SCHUSDZIARRA V SCHICK A D de la FUENTE A | 1983 | Endocrinology1983，112，3： | 1 |
| 6 | Isomerization of lactose catalyzed by alkaline-substituted sepiolites显示文摘 | FUENTES M A J(A)REZ M RAFAEL D VILLAMIEL M OLANO A | | 0，，03： | 1 |
| 7 | Long-time observations of the atmospheric exchange of CO2 with a temperate deciduous forest in southern Ontario显示文摘 | LEE X FUENTES J D STAEBLEER R M | 1999 | Journal Canada of Geophysical Research1999，14，15： | 1 |
| 8 | Rituximab therapy in refractory neuropsychiatric lupus: current clinical evidence显示文摘 | NARVAEZ J RIOS-RODRIGUEZ V DE LA FUENTE D | 2011 | Semin Arthritis Rheum2011，41，3： | 1 |
| 9 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 10 | First on-line analysis of petroleum from single inclusion using ultrafast laser ablation 显示文摘 | Volk H Fuentes D Fuerbach A | 2010 | Organic Geochemistry2010，41，2： | 1 |
| 11 | Tellurite: history, oxidative stress, and molecular mechanisms of resistance显示文摘 | Chasteen T G Fuentes D E Tantalean J C | 2009 | FEMS Microbiol Rev2009，33，4： | 1 |
| 12 | Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells 显示文摘 | Zaba L C Fuentes D J Eungdamrong N J | 2009 | J Invest Dermatol2009，129，1： | 1 |
| 13 | Studies of longterm weathering of aluminium in the atmosphere 显示文摘 | Fuente D de la Otero-Huerta E Morcillo M | 2007 | Corrosion Science2007，49，7： | 1 |
| 14 | Long-term observation of the atmospheric exchange of CO2 with a temperate de- ciduous forest in southern Ontario,Canada显示文摘 | Lee X Fuentes J D Staebler R M | 1999 | Journal of Geophysical Research1999，104，15： | 1 |
| 15 | Cross-talkbetween body iron stores and diabetes:iron stores areassociated with activity and microsatellite polymorphismof the heme oxygenase and type 2 diabetes显示文摘 | Arredondo M Fuentes M Jorquera D | 2011 | Biol TraceElem Res2011，143，2： | 1 |
| 16 | Effect of dietary supplementation with red wine extract or vitamin E, in combination with linseed and fish oil,on lamb meat quality显示文摘 | Muino I Apeleo E Fuente J D L | 2014 | Meat Science2014，98，2： | 1 |
| 17 | On the limits of post - industrial society: structural change and service sector employ ment in Spain 显示文摘 | Diaz Fuentes D | 1998 | International Review of Applied Economics1998，，12： | 1 |
| 18 | Redox speeiation analysis of antimony in soil extracts by hydride generation atomic fluorescence spectrometry显示文摘 | Fuentes E Pinochet H Gregori I D Potin-Gautier M | 2003 | Spectrochimica Acta Part B: Atomic Spectroscopy2003，58，7： | 1 |
| 19 | Effects of an epidermal growth factor receptor-based cancer vaccine on wound healing and inflammation processes in murine experimental models 显示文摘 | Fuentes D Chacon L Casaco A | 2014 | Int Wound J2014，11，1： | 1 |
| 20 | A virtual desktop revolution has arrived显示文摘 | Haiman Z Fuentes E Galic D | 2010 | Caribbean Business2010，38，33： | 1 |
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