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| 1 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Characterization and source apportionment of atmospheric organic and elemental carbon during fall and winter of 2003 in Xi’an, China显示文摘 | Cao J. J. Wu F. Chow J. C. Lee S. C. Li Y. Chen S. W. An Z. S. Fung K. K. Watson J. G. Zhu C. S. Liu S. X | 2005 | Atmospheric Chemistry and Physics2005，，56： | 6 |
| 4 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 5 | 年龄>75岁成人他汀类药物的使用情况及不良反应显示文摘自2013年美国心脏病学会/美国心脏协会指南发布以来,目前常规社区治疗实践中老年人用他汀类药物情况不很清楚。研究者比较了在不考虑指南推荐的年龄标准的情况下,符合接受一级或二级预防他汀类药物使用标准年龄〉75和≤75岁成年人的他汀类药物使用和剂量状况。 | 刘青 叶鹏 Nanna MG Navar AM Wang TY Mi X Virani SS Louie MJ Lee LV Goldberg AC Roger VL Robinson J Peterson ED | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 6 | Characterization and source apportionment of atmospheric organic and elemental carbon during fall and winter of 2003 in Xi’an, China显示文摘 | Cao J. J. Wu F. Chow J. C. Lee S. C. Li Y. Chen S. W. An Z. S. Fung K. K. Watson J. G. Zhu C. S. Liu S. X | 2005 | Atmospheric Chemistry and Physics2005，，56： | 3 |
| 7 | Stock market volatility, excess returns, and the role of investor sentiment显示文摘 | Wayne Y Lee Christine X Jiang Daniel C Indro | 2002 | Journal of Banking and Finance2002，，12： | 2 |
| 8 | Generation of cDNA probes directed by amino acid sequence: Cloning of urate oxidase 显示文摘 | Lee C C Wu X Gibbs R A | 1988 | Science1988，239，： | 2 |
| 9 | Sedentary behaviours and epithelial ovarian cancer risk显示文摘 | Zhang M Xie X Lee AH | 2004 | Cancer Causes Control2004，15，1： | 2 |
| 10 | Identification and speed control of ultrasonic motors based on neural networks显示文摘 | Xu X Liang YC Lee HP | 2003 | Journal of Micromechanics and Microengineering2003，13，1： | 2 |
| 11 | Impedance specifications for stable DC distributed power systems 显示文摘 | FENG X LIU J LEE F C | 2002 | IEEE Transactions on Power Electronics2002，17，2： | 1 |
| 12 | Metal contamination in urban, suburban and country park soils of Hong Kong: A study based on GIS and multivariate statistics显示文摘 | Lee C S Li X Shi W | 2006 | The Science of the Total Environment2006，356，13： | 1 |
| 13 | eyclase activating polypeptide27 Effects of pituitary adenylyl on cyclic AMP efflux and atrial dynamics in perfused beating atria显示文摘 | Cui X Lee SJ Kim SZ | 2000 | Eur J Pharmacol2000，402，12： | 1 |
| 14 | Preparation of Pt and PtRu nanoparticles supported on carbon nanotubes by microwave-assisted heating polyol process显示文摘 | Chen W X Lee Y J Liu Z L | 2004 | Materials Letters2004，58，： | 1 |
| 15 | High-fre- quency vibrations of crystal plates under initial stresses 显示文摘 | Lee P C Y Wang Y S Markenscoff X | 1975 | J Acoust Soc Am1975，57，1： | 1 |
| 16 | New developments in the chemistry and biology of the bioactive constituents of Tanshen显示文摘 | WANG X MORRIS-NATSCHKE S L LEE K H | 2007 | Med Res Rev2007，27，： | 1 |
| 17 | Terminal iterative learning control with an application to RTPCVD thickness control显示文摘 | Xu J X Chen Y Lee T | 1999 | Automatica1999，35，1： | 1 |
| 18 | Dynamic wetting and stress singularity on the contact line 显示文摘 | Wang X D Peng X F Lee D J | 2003 | Science in China E2003，46，4： | 1 |
| 19 | Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts显示文摘 | Lasbury ME Tang X Durant PJ Lee CH | 2003 | Infect Immun2003，71，9： | 1 |
| 20 | From TC, F-beta to cancer therapy显示文摘 | Huang X Lee C | 2003 | Curr Drug Targets2003，4，3： | 1 |
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