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| 1 | 时标上带有反馈控制的非自治两种群竞争系统的概周期解显示文摘该文利用时标理论,研究了一类时标上带有反馈控制的非自治两种群竞争系统.首先应用微分不等式和比较原理得到了系统的持久性,在此基础上,构造了一个合适的Lyapunov泛函,得到系统存在概周期解的充分条件.进一步,应用一个例子的数值模拟验证了该文结果的有效性. | 李周红 张丰硕 曹进德 Alsaedi Ahmed Alsaadi Fuad E | 2017 | 数学物理学报(A辑)2017，37，4： | 6 |
| 2 | Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model显示文摘Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross(CC), for dissecting host susceptibility for the development of T2 D and obesity, showing significant variations following high-fat(42% fat) diet(HFD). Here, we aimed to assessing the host genetic background and sex effects on T2 D and obesity development in response to oral-mixed bacterial infection and HFD using the CC lines.Materials and Methods: Study cohort consists of 97 mice from 2 CC lines(both sexes), maintained on either HFD or Standard diet(CHD) for 12 weeks. At week 5 a group of mice from each diet were infected with Porphyromonas gingivalis(Pg) and Fusobacterium nucleatum(Fn) bacteria(control groups without infection). Body weight(BW) and glucose tolerance ability were assessed at the end time point of the experiment.Results: The CC lines varied(P <.05) at their BW gain and glucose tolerance ability(with sex effect) in response to diets and/or infection, showing opposite responses despite sharing the same environmental conditions. The combination of diet and infection enhances BW accumulation for IL1912, while restraints it for IL72. As for glucose tolerance ability, only females(both lines) were deteriorated in response to infection.Conclusions: This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance. | Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，2： | 5 |
| 3 | Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines显示文摘Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. | Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-Haddad Fuad A.Iraqi | 2021 | Animal Models and Experimental Medicine2021，4，1： | 4 |
| 4 | Non-alcoholic fatty liver and chronic kidney disease:Retrospect,introspect,and prospect显示文摘With the growing prevalence of obesity and diabetes in the United States and across the world,a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease(NAFLD)is expected.The risk factors for NAFLD are also associated with the development of chronic kidney disease(CKD).We review the epidemiology,risk factors,genetics,implications of gut dysbiosis,and specific pathogenic mechanisms linking NAFLD to CKD.Mechanisms such as ectopic lipid accumulation,cellular signaling abnormalities,and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient population.Transplant evaluation in the setting of both NAFLD and CKD is also reviewed.Potential strategies for surveillance and management include the monitoring of comorbidities,the use of non-invasive fibrosis scoring systems,and the measurement of laboratory markers.Lastly,we discuss the management of patients with NAFLD and CKD,from preventative measures to experimental interventions. | Rajiv Heda Masahiko Yazawa Michelle Shi Madhu Bhaskaran Fuad Zain Aloor Paul J Thuluvath Sanjaya K Satapathy | 2021 | World Journal of Gastroenterology2021，27，17： | 3 |
| 5 | Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice显示文摘Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes. | Hanifa J.Abu-Toamih Atamni Maya Botzman Richard Mott Irit Gat-Viks Fuad A.Iraqi | 2018 | Animal Models and Experimental Medicine2018，1，3： | 3 |
| 6 | Impact of host genetics on gut microbiome: Take-home lessons from human and mouse studies显示文摘The intestinal microbiome has emerged as an important component involved in various diseases.Therefore,the interest in understanding the factors shaping its composition is growing.The gut microbiome,often defined as a complex trait,contains diverse components and its properties are determined by a combination of external and internal effects.Although much effort has been invested so far,it is still difficult to evaluate the extent to which human genetics shape the composition of the gut microbiota.However,in mouse studies,where the environmental factors are better controlled,the effect of the genetic background was significant.The purpose of this paper is to provide a current assessment of the role of human host genetics in shaping the gut microbiome composition.Despite the inconsistency of the reported results,it can be estimated that the genetic factor affects a portion of the microbiome.However,this effect is currently lower than the initial estimates,and it is difficult to separate the genetic influence from the environmental effect.Additionally,despite the differences between the microbial composition of humans and mice,results from mouse models can strengthen our knowledge of host genetics underlying the human gut microbial variation. | Inbal Cahana Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，3： | 2 |
| 7 | Wave-shaped microfluidic chip assisted point-of-care testing for accurate and rapid diagnosis of infections显示文摘Background:Early diagnosis and classification of infections increase the cure rate while decreasing complications,which is significant for severe infections,especially for war surgery.However,traditional methods rely on laborious operations and bulky devices.On the other hand,point-of-care(POC)methods suffer from limited robustness and accuracy.Therefore,it is of urgent demand to develop POC devices for rapid and accurate diagnosis of infections to fulfill on-site militarized requirements.Methods:We developed a wave-shaped microfluidic chip(WMC)assisted multiplexed detection platform(WMC-MDP).WMC-MDP reduces detection time and improves repeatability through premixing of the samples and reaction of the reagents.We further combined the detection platform with the streptavidin–biotin(SA-B)amplified system to enhance the sensitivity while using chemiluminescence(CL)intensity as signal readout.We realized simultaneous detection of C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)on the detection platform and evaluated the sensitivity,linear range,selectivity,and repeatability.Finally,we finished detecting 15 samples from volunteers and compared the results with commercial ELISA kits.Results:Detection of CRP,PCT,and IL-6 exhibited good linear relationships between CL intensities and concentrations in the range of 1.25–40μg/ml,0.4–12.8 ng/ml,and 50–1600 pg/ml,respectively.The limit of detection of CRP,PCT,and IL-6 were 0.54μg/ml,0.11 ng/ml,and 16.25 pg/ml,respectively.WMC-MDP is capable of good adequate selectivity and repeatability.The whole detection procedure takes only 22 min that meets the requirements of a POC device.Results of 15 samples from volunteers were consistent with the results detected by commercial ELISA kits.Conclusions:WMC-MDP allows simultaneous,rapid,and sensitive detection of CRP,PCT,and IL-6 with satisfactory selectivity and repeatability,requiring minimal manipulation.However,WMC-MDP takes advantage of being a microfluidic device showing the coefficients of variation less than 10%enabling WMC-MDP to be a type of point-of-care testing(POCT).Therefore,WMC-MDP provides a promising alternative to POCT of multiple biomarkers.We believe the practical application of WMC-MDP in militarized fields will revolutionize infection diagnosis for soldiers. | Bin-Feng Yin Xin-Hua Wan Ming-Zhu Yang Chang-Cheng Qian A.S.M.Muhtasim Fuad Sohan | 2022 | Military Medical Research2022，9，5： | 2 |
| 8 | Hydromagnetic peristaltic transport of copper-water nanofluid with temperature-dependent effective viscosity显示文摘 | Fahad M. Abbasi Tasawar Hayat Sabir A. Shehzad Fuad Alsaadi Naif Altoaibi | 2016 | Particuology2016，14，4： | 2 |
| 9 | Appropriateness of indication and diagnostic yield of colonoscopy: First report based on the 2000 guidelines of the American Society for Gastrointestinal Endoscopy显示文摘AIM: To assess the appropriateness of referrals and to determine the diagnostic yield of colonoscopy according to the 2000 guidelines of the American Society for Gastrointestinal Endoscopy (ASGE).METHODS: A total of 736 consecutive patients (415males, 321 females; mean age 43.6±16.6 years)undergoing colonoscopy during October 2001-March2002 Were prospectively enrolled in the study. The 2000ASGE guidelines were used to assess the appropriateness of the indications for the procedure. Diagnostic yield was defined as the ratio between significant findings detected on colonoscopy and the total number of procedures performed for that indication.RESULTS: The large majority (64%) of patients had colonoscopy for an indication that was considered'generally indicated'; it was 'generally not indicated' for20%, and it was 'not listed' for 16% in the guidelines.The diagnostic yield of colonoscopy was highest for the 'generally indicated' (38%) followed by 'not listed'(13%) and 'generally not indicated' (5%) categories.In the multivariable analysis, the diagnostic yield was independently associated with the appropriateness of indication that was 'generally indicated' (odds ratio=12.3) and referrals by gastroenterologist (odds ratio = 1.9).CONCLUSION: There is a high likelihood of inappropriate referrals for colonoscopy in an open-access endoscopy system. The diagnostic yield of the procedure is dependent on the appropriateness of indication and referring physician's specialty. Certain indications 'not listed' in the guidelines have an intermediate diagnostic yield and further studies are required to evaluate whether they should be included in future revisions of the ASGE guidelines. | Iqbal Siddique Krishna Mohan Fuad Hasan Anjum Memon Istvan Patty Basil Al-Nakib | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 10 | Simultaneous effects of Hall current and thermal deposition in peristaltic transport of Eyring-Powell fluid显示文摘 | T. Hayat Anum Tanveer Humaira Yasmin Fuad Alsaadi | 2015 | International Journal of Biomathematics2015，8，2： | 2 |
| 11 | High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds显示文摘Background:Type 2 diabetes(T2D)is an adult-onset and obese form of diabetes caused by an interplay between genetic,epigenetic,and environmental components.Here,we have assessed a cohort of 11 genetically different collaborative cross(CC)mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high-fat diet(HFD)challenges.Methods:Mice were fed with either the HFD or the standard chow diet(control group)for 12 weeks starting at the age of 8 weeks.At week 5 of the experiment,half of the mice of each diet group were infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria strains.Throughout the 12-week experimental period,body weight(BW)was recorded biweekly,and intraperitoneal glucose tolerance tests were performed at weeks 6 and 12 of the experiment to evaluate the glucose tolerance status of mice.Results:Statistical analysis has shown the significance of phenotypic variations between the CC lines,which have different genetic backgrounds and sex effects in different experimental groups.The heritability of the studied phenotypes was estimated and ranged between 0.45 and 0.85.We applied machine learning methods to make an early call for T2D and its prognosis.The results showed that classification with random forest could reach the highest accuracy classification(ACC=0.91)when all the attributes were used.Conclusion:Using sex,diet,infection status,initial BW,and area under the curve(AUC)at week 6,we could classify the final phenotypes/outcomes at the end stage of the experiment(at 12 weeks). | Iqbal M.Lone Nadav Ben Nun Aya Ghnaim Arne S.Schaefer Yael Houri-Haddad Fuad A.Iraqi | 2023 | Animal Models and Experimental Medicine2023，6，2： | 2 |
| 12 | Polypropylene/polystyrene blends-preliminary studies for compatibilization by aromatic-grafted polypropylene显示文摘 | Syed Mustafa S J Nor Azlan M R Ahmad Fuad M Y | 2001 | J Appl Polym Sci2001，82，： | 1 |
| 13 | Laparoscopic closure of perforated duodenal ulcer显示文摘 | Khoursheed M Fuad M Safar H | 2000 | Surg Endosc2000，14，1： | 1 |
| 14 | Gene expression profiling in an in Vitro model of angiogenesis显示文摘 | Janne Kahn Fuad Mehraban Gladys Ingle | 2000 | Amerrican Journal of Pathology2000，15，6： | 1 |
| 15 | Rhinosinusitis: Establishing definitions for clinical research and patient care显示文摘 | Eli O. Meltzer Daniel L. Hamilos James A. Hadley Donald C. Lanza Bradley F. Marple Richard A. Nicklas Claus Bachert James Baraniuk Fuad M. Baroody Michael S. Benninger Itzhak Brook Badrul A. Chowdhury Howard M. Druce Stephen Durham Berrylin Ferguson Jack | 2004 | The Journal of Allergy and Clinical Immunology2004，，6： | 1 |
| 16 | The effect of stage temperature drop on MVC thermal performance 显示文摘 | Fuad N Alasfour Hassan K Abdulrahim | 2011 | Desalination2011，265，13： | 1 |
| 17 | A review on current researeh trends in electrical discharge machining (EDM) 显示文摘 | Abbas N M Solomon D G Fuad Bahari Md | 2007 | International Journal of Machine Tools and Manufacture2007，47，78： | 1 |
| 18 | Diabetic nephropathy and transforming growth factor-β: transforming our view of glomerulosclerosis and fibrosis build-up显示文摘 | Sheldon Chen Belinda Jim Fuad N Ziyadeh | 2003 | Seminars in Nephrology2003，，6： | 1 |
| 19 | Importance of microbi-ological e-valuation in management of infectious complica-tions following pecutaneous nephrolithotomy显示文摘 | Hasan SD Fuad G Yesim S | 2007 | Int UrolNephrol2007，39，2： | 1 |
| 20 | Individualization of the biopsy protocol according to the prostate gland volume for prostate cancer detection 显示文摘 | Saadettin Yilmaz Eskicorapci Fuad guliyev | 2005 | J Urol2005，173，： | 1 |
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