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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice显示文摘瞄准:小檗硷被认为是一个免疫调节的人因此现在的学习试图在它的行动的 endotoxemic 老鼠,和机制在死亡,肺和肠损害上调查小檗硷的效果。方法:老鼠与脂肪的多糖被质问(LPS, 28 mg/kg, ip ) ,并且中立硫酸盐小檗硷 intragastrically 被管理。死亡被监视象血浆肿瘤坏死 factor-alpha (TNF-alpha ) 一样的肺和肠的每 12 h,和组织学,干扰素 -- 鲸鱼群妈(IFN-gamma ) , interleukin-12 (IL-12 ) , IL-10,和氮的氧化物(没有) 层次被检验。结果:有 50 mg/kg 的预告的处理中立硫酸盐小檗硷一旦为 5 天的一天显著地减少了,死亡率和在老鼠的肺和小肠的稀释织物损害与 LPS 质问了。LPS 在小檗硷的管理显著地减少了的 TNF-alpha, IFN- 鲸鱼群妈, IL-12, IL-10,和号码的血浆层次刺激了显著增加血浆 TNF-alpha, IFN- 鲸鱼群妈,和没有层次,但是没在暴露于 LPS 的老鼠压制血浆 IL-12 层次。而且,有中立硫酸盐小檗硷的预告的处理扩充了 LPS 在老鼠刺激的 IL-10 分泌物。结论:有中立硫酸盐小檗硷的预告的处理稀释织物损害并且在 endotoxemic 老鼠改进幸存,它可以被调停,至少部分地,由支持 inflammatory 调停人生产并且在 IL-10 的规定上面的抑制版本。这些调查结果可能为 endotoxemia 的处理提供新策略。 | Fei LI Hua-dong WANG Da-xiang LU Yan-ping WANG Ren-bin QI Yong-mei FU Chu-jie LI | 2006 | Acta Pharmacologica Sinica2006，27，9： | 23 |
| 3 | A comparison of two kinds of eastward-moving mesoscale vortices during the mei-yu period of 2010显示文摘During the mei-yu period,the east edge of the Tibetan Plateau and the Dabie Mountain are two main sources of eastward-moving mesoscale vortices along the mei-yu front(MYF).In this study,an eastward-moving southwest vortex(SWV) and an eastward-moving Dabie vortex(DBV) during the mei-yu period of 2010 have been investigated to clarify the main similarities and differences between them.The synoptic analyses reveal that the SWV and DBV were both located at the lower troposphere;however,the SWV developed in a 'from top down' trend,whereas the DBV developed in an opposite way.There were obvious surface closed low centers corresponding to the DBV during its life span,whereas for the SWV,the closed low center only appeared at the mature stage.Cold and warm air intersected intensely after the formation of both the vortices,and the cold advection in the SWV case was stronger than that in the DBV case,whereas the warm advection in the DBV case was more intense than that in the SWV case.The Bay of Bengal and the South China Sea were main moisture sources for the SWV,whereas for the DBV,in addition to the above two moisture sources,the East China Sea was also an important moisture source.The vorticity budget indicates that the convergence was the most important common factor conducive to the formation,development,and maintenance of the SWV and DBV,whereas the conversion from the vertical vorticity to the horizontal one(tilting) was the most important common factor caused the dissipation of both of the vortices.The kinetic energy(KE) budget reveals that the KE generation by the rotational wind was the dominant factor for the enhancement of KE associated with the SWV,whereas for the DBV,the KE transport by the rotational wind was more important than the KE generation.The KE associated with the SWV and the DBV weakened with different mechanisms during the decaying stage.Furthermore,the characteristics of baroclinic and barotropic energy conversions during the life spans of both vortices indicate that the SWV and DBV both belong to the kind of subtropical mesoscale vortices. | FU ShenMing YU Fei WANG DongHai XIA RuDi | 2013 | Science China Earth Sciences2013，56，2： | 18 |
| 4 | Brain structural changes and their correlation with vascular disease in type 2 diabetes mellitus patients: a voxel-based morphometric study显示文摘Voxel-based morphometry has been used in the study of alterations in brain structure in type 1 diabetes mellitus patients. These changes are associated with clinical indices. The age at onset, pathogenesis, and treatment of type 1 diabetes mellitus are different from those for type 2 diabetes mellitus. Thus, type 1 and type 2 diabetes mellitus may have different impacts on brain structure. Only a few studies of the alterations in brain structure in type 2 diabetes mellitus patients using voxel-based morphometry have been conducted, with inconsistent results. We detected subtle changes in the brain structure of 23 cases of type 2 diabetes mellitus, and demonstrated that there was no significant difference between the total volume of gray and white matter of the brain of type 2 diabetes mellitus patients and that in controls. Regional atrophy of gray matter mainly occurred in the right temporal and left occipital cortex, while regional atrophy of white matter involved the right temporal lobe and the right cerebellar hemisphere. The ankle-brachial index in patients with type 2 diabetes mellitus strongly correlated with the volume of brain regions in the default mode network. The ankle-brachial index, followed by the level of glycosylated hemoglobin, most strongly correlated with the volume of gray matter in the right temporal lobe. These data suggest that voxel-based morphometry could detect small structural changes in patients with type 2 diabetes mellitus. Early macrovascular atherosclerosis may play a crucial role in subtle brain atrophy in type 2 diabetes mellitus patients, with chronic hyperglycemia playing a lesser role. | Chunxia Wang Kailiang Fu Huaijun Liu Fei Xing Songyun Zhang | 2014 | Neural Regeneration Research2014，9，16： | 15 |
| 5 | Liver transplant recipients with portal vein thrombosis:a single center retrospective study显示文摘BACKGROUND:Portal vein thrombosis(PVT)used to be a contraindication for liver transplantation(LT).This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODS:A total of 465 adult LTs were performed from December 2002 through December 2006.Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading(Yerdel grading).Comparison of risk factors,variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. RESULTS:In the 465 LTs,42 were operatively confirmed to have PVT(9.0%)(19 recipients with grade 1,14 with grade 2,7 with grade 3,and 2 with grade 4).Increased age and treatment of portal hypertension were associated with PVT.Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy.In grade 3 PVT patients,the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed.Grade 4 PVT was managed by our modified cavoportal hemitransposition technique.The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion(P>0.05).The flow rate of the PV was lower in the PVT patients(48.881±12.788 cm/s)than in the controls(57.172±21.715 cm/s,P<0.05).The PVT patients had such postoperative complications as renal failure and PV rethrombosis(P<0.05).The 1-year survival rates in PVT and non-PVT patients were 78.6%and 76.4%respectively (P>0.05);the 3-year survival rates were 58.8%and 56.4% respectively(P>0.05). CONCLUSIONS:PVT is not contraindicated for LT if it is graded.PVT recipients may have post-transplantation complications like renal failure and PV rethrombosis,and operative difficulty and patient survival are similar to those in recipients without PVT.Development of therapeutic approaches and accumulation of experience in dealing with PVT further improve the outcomes of LT in PVT recipients. | Tao, Yi-Feng Teng, Fei Wang, Zheng-Xin Guo, Wen-Yuan Shi, Xiao-Min Wang, Gui-Hua Ding, Guo-Shan Fu, Zhi-Ren | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 14 |
| 6 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 7 | A data-driven method for syndrome type identification and classification in traditional Chinese medicine显示文摘The efficacy of traditional Chinese medicine(TCM) treatments for Western medicine(WM) diseases relies heavily on the proper classification of patients into TCM syndrome types.The authors developed a data-driven method for solving the classification problem,where syndrome types were identified and quantified based on statistical patterns detected in unlabeled symptom survey data.The new method is a generalization of latent class analysis(LCA),which has been widely applied in WM research to solve a similar problem,i.e.,to identify subtypes of a patient population in the absence of a gold standard.A well-known weakness of LCA is that it makes an unrealistically strong independence assumption.The authors relaxed the assumption by first detecting symptom co-occurrence patterns from survey data and used those statistical patterns instead of the symptoms as features for LCA.This new method consists of six steps:data collection,symptom co-occurrence pattern discovery,statistical pattern interpretation,syndrome identification,syndrome type identification and syndrome type classification.A software package called Lantern has been developed to support the application of the method.The method was illustrated using a data set on vascular mild cognitive impairment. | Nevin Lianwen Zhang Chen Fu Teng Fei Liu Bao-xin Chen Kin Man Poon Pei Xian Chen Yun-ling Zhang | 2017 | Journal of Integrative Medicine2017，15，2： | 11 |
| 8 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 9 | Vegetation dynamics induced by groundwater fluctuations in the lower Heihe River Basin,northwestern China显示文摘Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in this region.The aim of this study was to explore the impacts of groundwater fluctuations on vegetation dynamics.Our results can be used as a reference for water resources planning and management to maintain proper environmental flows in arid areas.Methods The location(by Global Positioning System)and depth of the monitoring wells,as well as groundwater table depth and salinity were measured in situ at each site from July to August 2009.Based on the measurements of the groundwater table depth and salinity following the implementation of environmental flow controls project(EFCP)in the lower Heihe River Basin,the groundwater fluctuations during the period from 2001 to 2009 were analyzed.Descriptive statistics and Pearson’s correlation were used to analyze the relationship between vegetation changes and groundwater table fluctuations.Additionally,the spatial distributions of the groundwater table depth and salinity were interpolated using the simple kriging method.Trend analysis was applied to the time series of integrated Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index data to identify interannual vegetation dynamics.The relationship between vegetation status and groundwater environment was investigated at different spatial scales by analyzing and comparing the time series and trends.Important Findings(i)The groundwater table and salinity increased significantly in most of the study area with spatial heterogeneity.On average,the groundwater table rose;0.5 and 1.5 m in the upper and lower Ejina Basin,respectively,and the groundwater salinity increased across the study area by 0–4%.(ii)A notable correlation between the vegetation status and the groundwater table was revealed when the groundwater table depth fluctuated between 1.8 and 3.5 m,whereas the vegetation did not show an obvious response to groundwater table changes when the groundwater table depth was more than 5–6 m.(iii)Vegetation restoration mainly occurred in riparian areas within 500–1000 m of from natural rivers,where the groundwater table depth varied from 2 to 4 m,and salinity was<5%,whereas vegetation degradation appeared at some locations where groundwater environment had deteriorated. | Ping Wang Yichi Zhang Jingjie Yu Guobin Fu Fei Ao | 2011 | Journal of Plant Ecology2011，4，1： | 10 |
| 10 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 11 | Artificial intelligence in drug design显示文摘Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical trials.Owing to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design. | Feisheng Zhong Jing Xing Xutong Li Xiaohong Liu Zunyun Fu Zhaoping Xiong Dong Lu Xiaolong Wu Jihui Zhao Xiaoqin Tan Fei Li Xiaomin Luo Zhaojun Li Kaixian Chen Mingyue Zheng Hualiang Jiang | 2018 | Science China(Life Sciences)2018，61，10： | 10 |
| 12 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 13 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 14 | Geographic variation of chloroplast DNA in Platycarya strobilacea (Juglandaceae)显示文摘摘要 monotypic 类 Platycarya (Juglandaceae ) 是在东亚的最普遍的适度的树种类之一。在这研究,我们实现了用叶绿体 DNA (cpDNA )(psbA-trnH 和 atpB-rbcL intergenic 分隔符) 的学习在 Platycarya strobilacea 上定序的 phylogeographical,主要 refugia 和移植发送以便识别种类的地点。P 的 180 个个人的一个总数。从从中国和 Jeju 岛(朝鲜) 的 27 张人口的 stobilacea 是镇定的。结果揭示了那 P。strobilacea 为二个 intergenic 分隔符和高基因差异有 35 haplotypes (hT= 0.926 ) 。haplotypes 的这令人惊讶地高的差异显示它的长进化的历史,它与以前的种系发生的分析和石块记录一致。重要 cpDNA 人口分被检测(GST= 0.720;NST= 0.862 ) ,通过在人口和重要 phylogeographical 之中的种子的周期性的基因流动的建议底层组织(NST > GST, P < 0.05 ) 。35 chlorotypes 的种系发生的关系的构造检测了四主要 cpDNA clades。用野兽的分叉标明日期分析建议主要 cpDNA clades 的分叉以前发生了中新世。人口统计的分析显示东方 clade 经历了局部性的人口统计的扩大。分子的种系发生的数据和 haplotypes 的地理分发,通过第四级的气候的摆动在中国在大多数它的当前的范围建议多重冰川的 refugia 的存在。 | Shi-Chao CHEN Li ZHANG Jie ZENG Fei SHI Hong YANG Yun-Rui MAO Cheng-Xin FU | 2012 | Journal of Systematics and Evolution2012，50，4： | 10 |
| 15 | Hemolymphangioma: A rare differential diagnosis of cystic-solid or cystic tumors of the pancreas显示文摘We report a case of pancreatic hemolymphangioma. Hemolymphangioma is a malformation of both lymphatic vessels and blood vessels. The incidence of this disease in the pancreas is extremely rare. To the best of our knowledge, only seven cases have been reported worldwide (PubMed). A 39-year-old woman with a oneday history of abdominal pain was admitted to our hospital. There was no obvious precipitating factor. The preoperative examination, including ultrasonography and computed tomography, showed a cystic-solid tumor in the pancreas, and it was considered to be a mucinous cystadenoma or cystadenocarcinoma. Pancreaticbody-tail resection combined with splenectomy was performed. After the operation, the tumor was pathologically demonstrated to be a pancreatic hemolymphangioma. Although pancreatic hemolymphangioma is rare, we believe that it should be considered in the differential diagnosis of cystic-solid tumors of the pancreas, particularly when there is no sufficient evidence for diagnosing cystadenoma, cystadenocarcinoma or some other relatively common disease of the pancreas. | Fei Dong Yi Zheng Jian-Jun Wu Yan-Biao Fu Kai Jin Ming Chao | 2013 | World Journal of Gastroenterology2013，19，22： | 10 |
| 16 | Effects of Grazing Exclusion on Soil Carbon and Nitrogen Storage in Semi-arid Grassland in Inner Mongolia, China显示文摘The semi-arid grasslands in Inner Mongolia, China have been degraded by long-term grazing. A series of ecological restoration strategies have been implemented to improve grassland service. However, little is known about the effect of these ecological restoration practices on soil carbon and nitrogen storage. In this study, characteristics of vegetation and soil properties under continued grazing and exclusion of livestock for six years due to a nationwide conservation program—′Returning Grazing Lands to Grasslands(RGLG)′ were examined in semi-arid Hulun Buir grassland in Inner Mongolia, China. The results show that removal of grazing for six years resulted in a significant recovery in vegetation with higher above and below-ground biomass, but a lower soil bulk density and pH value. After six years of grazing exclusion, soil organic C and total N storage increased by 13.9% and 17.1%, respectively, which could be partly explained by decreased loss and increased input of C and N to soil. The effects of grazing exclusion on soil C and N concentration and storage primarily occurred in the upper soil depths. The results indicate that removal of grazing pressure within the RGLG program was an effective restoration approach to control grassland degradation in this region. However, more comprehensive studies are needed to evaluate the effectiveness of the RGLG program and to improve the management strategies for grassland restoration in this area. | WU Xing LI Zongshan FU Bojie LU Fei WANG Dongbo LIU Huifeng LIU Guohua | 2014 | Chinese Geographical Science2014，24，4： | 10 |
| 17 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 18 | In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine显示文摘Berberrubine (BRB ) 是在 vivo 比 BBR 显示出更强壮的葡萄糖阴沉的效果的 berberine (BBR ) 的主要代谢物。在另一方面, BRB 快速并且广泛地被使产生代射变化进 berberrubine-9-O -- 在在口头的管理以后的老鼠的 D-glucuronide (BRBG ) 。在这研究,我们在老鼠比较了 BRB 和 BRBG 的 pharmacokinetic 性质,并且探索了位于他们的葡萄糖阴沉的活动下面的机制。有导致 HFD 的多糖症的 C57BL/6 老鼠被管理 BRB (50 mg 吗?? | Na YANG Run-bin SUN Xing-long CHEN Le ZHEN Chun GE Yu-qing ZHAO Jun HE Jian-liang GENG Jia-hua GUO Xiao-yi YU Fei FEI Si-qi FENG Xuan-xuan ZHU Hong-bo WANG Feng-hua FU Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 9 |
| 19 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hoqpfpqupxnk06cf9.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hoqpfpqupxnk06cf9.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 20 | CuFe2O4@GO nanocomposite as an effective and recoverable catalyst of peroxymonosulfate activation for degradation of aqueous dye pollutants显示文摘Recently,heterogeneous activation of peroxymonosulfate(PMS) to oxidatively degrade organic pollutants has been a hotspot.In the present work,copper ferrite-graphite oxide hybrid(CuFe2 O4@GO)was prepared and used as catalyst to activate PMS for degradation of methylene blue(MB) in aqueous solution.A high degradation efficiency(93.3%) was achieved at the experimental conditions of20 mg/L MB,200 mg/L CuFe2 O4@GO,0.8 mmol/L PMS,and 25℃temperature.Moreover,CuFe2 O4@GO showed an excellent reusability and stability.The effects of various operational parameters including pollutant type,solution pH,catalyst dosage,PMS dosage,pollutant concentration,temperature,natural organic matter(NOM),and inorganic anions on the catalytic degradation process were comprehensively investigated and elucidated.The further mechanistic study revealed the Cu(Ⅱ)/Cu(Ⅰ) redox couple on CuFe2 O4@GO played the dominant role in PMS activation,where both hydroxyl and sulfate radicals were generated and proceeded the degradation of pollutants.In general,CuFe2 O4@GO is a promising heterocatalyst for PMS-based advanced oxidation processes(AOPs) in wastewater treatment. | Xiaoman Lei Menghan You Fei Pan Min Liu Peng Yang Dongsheng Xia Qiang Li Yanting Wang Jie Fu | 2019 | Chinese Chemical Letters2019，30，12： | 8 |
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