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| 1 | Applications of HPLC/MS in the analysis of traditional Chinese medicines显示文摘In China,traditional Chinese medicines(TCMs)have been used in clinical applications for thousands of years.The successful hyphenation of high-performance liquid chromatography(HPLC)and mass spectrometry(MS)has been applied widely in TCMs and biological samples analysis.Undoubtedly,HPLC/MS technique has facilitated the understanding of the treatment mechanism of TCMs.We reviewed more than 350 published papers within the last 5 years on HPLC/MS in the analysis of TCMs.The present review focused on the applications of HPLC/MS in the component analysis,metabolites analysis,and pharmacokinetics of TCMs etc.50% of the literature is related to the component analysis of TCMs,which show that this field is the most popular type of research.In the metabolites analysis,HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry has been demonstrated to be the powerful tool for the characterization of structural features and fragmentation behavior patterns.This paper presented a brief overview of the applications of HPLC/MS in the analysis of TCMs.HPLC/MS in the fingerprint analysis is reviewed elsewhere. | Miao Li Xiao- Fang Hou Jie Zhang Si-Cen Wang Qiang Fu Lang- Chong He | 2011 | Journal of Pharmaceutical Analysis2011，1，2： | 17 |
| 2 | Bimetallic Pd-Ni core-shell nanoparticles catalysts for the Suzuki reaction显示文摘 | Ji Xiang Peng Li Hanbao Chong Li Feng Fangyu Fu Zhuang Wang Shilin Zhang Manzhou Zhu | 2014 | Nano Research2014，7，9： | 11 |
| 3 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 4 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 5 | Application of in vitro and in vivo models in the study of food allergy显示文摘Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy. | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu | 2018 | Food Science and Human Wellness2018，7，4： | 7 |
| 6 | The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice显示文摘G-protein signaling and ubiquitin-dependent degradation are both involved in grain development in rice,but how these pathways are coordinated in regulating this process is unknown.Here,we show that Chang Li Geng 1(CLG1),which encodes an E3 ligase,regulates grain size by targeting the Gγprotein GS3,a negative regulator of grain length,for degradation.Overexpression of CLG1 led to increased grain length,while overexpression of mutated CLG1 with changes in three conserved amino acids decreased grain length.We found that CLG1 physically interacts with and ubiquitinats GS3which is subsequently degraded through the endosome degradation pathway,leading to increased grain size.Furthermore,we identified a critical SNP in the exon 3 of CLG1 that is significantly associated with grain size variation in a core collection of cultivated rice.This SNP results in an amino acid substitution from Arg to Ser at position 163 of CLG1 that enhances the E3 ligase activity of CLG1 and thus increases rice grain size.Both the expression level of CLG1 and the SNP CLG1163S may be useful variations for manipulating grain size in rice. | Wensi Yang Kun Wu Bo Wang Huanhuan Liu Siyi Guo Xiaoyu Guo Wei Luo Shengyuan Sun Yidan Ouyang Xiangdong Fu Kang Chong Qifa Zhang Yunyuan Xu | 2021 | Molecular Plant2021，14，10： | 6 |
| 7 | Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China显示文摘这研究试图评估敏感和特性新临床诊断并且为用六个临床的标记的 Kashin 山涧疾病(KBD ) 的分类标准:手指的远侧的部分的屈曲,使变形的手指,扩大手指关节,弄短的手指,蹲下来,并且侏儒症。在 Linyou 县的三分之一个张全部的人口被成层的随机的采样取样。调查包括了基线特征并且临床诊断,并且新标准的敏感和特性被评估。我们鉴别 3,459 个 KBD 病人, 69 早有上演 KBD, 1,952 有的舞台我, 1,132 有的阶段 II,和 306 有的阶段 III。分类的屏蔽测试作为舞台扩大了手指关节我 KBD 与 0.978 和 0.045 的敏感和特性,分别地。分别地,弄短的手指作为阶段 II KBD 被分类,与 0.969 和 0.844 的敏感和特性,侏儒症分别地与 0.951 和 0.992 的敏感和特性作为阶段 III KBD 被分类。连续屏蔽测试表明 KBD 的新临床的分类分类阶段与 0.949, 0.945,和 0.925 的敏感和 0.967, 0.970,和 0.993 的特性我, II,和 III KBD 分别地。屏蔽测试表明扩大手指关节,弄短的手指,和侏儒症是为有高敏感和特性的 KBD 的临床的诊断和分类的适当标记。 | YU Fang Fang PING Zhi Guang YAO Chong WANG Zhi Wen WANG Fu Qi GUO Xiong | 2017 | Biomedical and Environmental Sciences2017，30，2： | 6 |
| 8 | Indication of lower neck irradiation in nasopharyngeal carcinoma without nodal metastasis: the potential impact of tumor volume显示文摘 | FU Jie ZHOU Jia-yin Vincent FH CHONG James BK Khoo | 2013 | Chinese Medical Journal2013，，11： | 5 |
| 9 | Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers显示文摘In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples. | Ya Li Qiang Fu Meng Liu Yuan-Yuan Jiao Wei Du Chong Yu Jing Liu Chun Chang Jian Lu | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 4 |
| 10 | Nonlinear Reduction in Risk for Type 2 Diabetes by Magnesium Intake:An Updated Meta-Analysis of Prospective Cohort Studies显示文摘Observational studies between magnesium intake and risk of type 2 diabetes yielded inconsistent results.We conducted a system literature search of PubM ed database through March 2015 for prospective cohort studies of magnesium intake and type 2 diabetes risk.Study-specific results were pooled in a random-effects model.Subgroup and sensitivity analysis were performed to assess | XU Tian CHEN Guo Chong ZHAI Lin KE Kai Fu | 2015 | Biomedical and Environmental Sciences2015，28，7： | 4 |
| 11 | Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women显示文摘Plastin 3 (PLS3) has been identified as a candidate gene for bone fragility in the Rotterdam study (RS) population. So far, however, whether PLS3 polymorphisms are genetic risk factors for osteoporosis in Asian population remains unclear. In order to investigate the association between genetic variants in PLS3 and the risk of fragility fracture and/or bone mineral density (BMD) in postmenopausal Chinese women, we conducted a case-control association study. A total of 1083 postmenopausal patients with osteoporotic fractures and 2578 unrelated non-fracture controls in Shanghai were enrolled. Seven SNPs, including six tagSNPs in PLS3 and one identified genetic risk factor (rs140121121) for osteoporosis in the RS population, were genotyped in all the participants. BMD at lumbar spine and hip sites were measured in 2578 controls. Association between SNPs and the risk of osteoporotic fractures and/or BMD were analyzed. The GC genotype of rs757124 and AC genotype of rs10521693 were associated with lumbar vertebral fracture (P=0.020 and 0.046, respectively). The association between tagSNPs and BMD were analyzed only in 2546 controls to avoid biased conclusion. rs757124 was significantly associated with BMD at lumbar spine and hip sites. GG genotype had the highest BMD at lumbar spine (L1-4), while CC genotype had the highest BMD at hip sites. Our results suggest that polymorphisms in PLS3 are genetic loci for osteoporosis in postmenopausal Chinese women. | Chong Shao Yi-wen Wang Jin-wei He Wen-zhen Fu Chun Wang Zhen-lin Zhang | 2019 | Acta Pharmacologica Sinica2019，40，9： | 3 |
| 12 | Mapping the fallowed area of paddy fields on Sanjiang Plain of Northeast China to assist water security assessments显示文摘Rice growth requires a large amount of water,and planting rice will increase the contradiction between supply and demand of water resources.Paddy field fllowing is important for the sustainable development of an agricultural region,but it remains a great challenge to accurately and quickly monitor the extent and area of fallowed paddy fields.Paddy fields have unique physical features associated with paddy rice during the flooding and transplanting phases.By comparing the differences in phenology before and after paddy field fllowing,we proposed a phenology-based fallowed paddy field mapping algorithm.We used the Google Earth Engine(GEE)cloud computing platform and Landsat 8 images to extract the fllowed paddy field area on Sanjiang Plain of China in 2018.The results indicated that the Landsat8,GEE,and phenology-based fllowed paddy field mapping algorithm can effectively support the mapping of fallowed paddy fields on Sanjiang Plain of China.Based on remote sensing monitoring,the total fallowed paddy field area of Sanjiang Plain is 91543 ha.The resultant fallowed paddy field map is of high accuracy,with a producer(user)accuracy of 83%(81%),based on validation using ground-truth samples.The Landsat-based map also exhibits high consistency with the agricultural statistical data.We estimated that paddy field fallowing reduced irigation water by 384-521 million cubic meters on Sanjiang Plain in 2018.The research results can support subsidization grants for fallowed paddy fields,the evaluation of fallowed paddy field effects and improvement in subsequent fallowed paddy field policy in the future. | LUO Chong LIU Huan-jun FU Qiang GUAN Hai-xiang YE Qiang ZHANG Xin-le KONG Fan-chang | 2020 | Journal of Integrative Agriculture2020，19，7： | 3 |
| 13 | Electrical properties and luminescence properties of 0.96(K0.48Na0.52)(Nb0.95Sb0.05)–0.04Bi0.5(Na0.82K0.18)0.5ZrO3–xSm lead-free ceramics显示文摘In this paper,Sm-doped 0.96(K0.48 Na0.52)(Nb0.95 Sb0.05)–0.04 Bi0.5(Na0.82 K0.18)0.5 Zr O3(abbreviated as KNSN–0.04 BNKZ)lead-free piezoelectric ceramics were prepared by conventional solid-state sintering method and the effects of Sm2 O3 on the phase structure,microstructure,electrical and luminescent properties of KNSN–0.04 BNKZ potteries were studied.Results revealed that a single solid solution phase with pseudo-cubic perovskite structure was formed between KNSN–0.04 BNKZ and Sm2 O3.Existence of weak dielectric/ferroelectric properties with a diffuse dielectric anomaly and slim P–E hysteresis loops of the Sm-doped KNSN–0.04 BNKZ demonstrated the ferroelectric relaxor behavior of the KNNS–0.04 BNKZ–x Sm ceramics.Accordingly,the temperature stability and fatigue behavior of the modified ceramics were significantly improved.It was found that the KNSN–0.04 BNKZ ceramics with 0.002 mol Sm addition exhibited nearly temperature independent properties and fatigue-free behavior.Moreover,Sm-modified KNSN–0.04 BNKZ exhibits a bright photoluminescence with a strong orange emission under visible light irradiation.As a material with both electrical and luminescent properties,it has good application prospect in future optoelectronic components by integrating its luminescent and electrical properties. | Wei LI Jigong HAO Wei LI Juan DU Peng FU Wenzhi SUN Chong CHEN Zhijun XU Ruiqing CHU | 2020 | Journal of Advanced Ceramics2020，9，1： | 2 |
| 14 | Mechanism and practice of rock control in deep large span cut holes显示文摘Deep large span cut holes are difficult to stabilize. The 7801 cut hole in the Lu'an Wuyang Mine was used as this project's background. The main factors affecting large span cut hole stability are analyzed. Pre- stressed bolting theory was used to design a roof control method for a large span roadway. By reducing the span and applying equal strength coordinated supports the rock could be stabilized. The control prin- ciples and methods are given herein along with the analysis. A double micro arch cross section roadway is defined and its use in solving the current problem is described. Beam arch theory was used to build a model of the double micro arch cross section roadway. A support reverse force model for the arch foot intersection was also derived. A support method based upon reducing the width of the large span in the cut hole is presented. These results show that the reduced span of the roadway roof plus the use of cable anchors and single supports gives an effective way to control the large span cut hole. On site monitoring showed that the reduced span support from the double micro arch cross section roadway design had a significant effect. The roadway surface displacement was small and harmful deformation of the cut hole was effectively controlled. This will ensure its long term stability. | Li Chong Xu Jinhai Fu Chunsheng Wu Rui Ma Qianqian | 2011 | Mining Science and Technology2011，21，6： | 2 |
| 15 | Microstructures and erosion-corrosion behavior of Fe-B alloy containing chromium and nickel显示文摘The Fe-B alloy containing chromium and nickel was prepared, and the microstructure and erosioncorrosion behavior of the alloy were investigated by means of scanning electron microscopy, energy dispersive X-ray spectrometry, X-ray diffraction analysis, Leica digital image analysis, a hardness tester and an erosioncorrosion tester. Cr28 white cast iron was used for comparison. Results show that the microstructures of both as-cast and heat-treated Fe-B alloys consist of austenite and borocarbide. The nickel and chromium elements are mainly distributed over the matrix and borocarbide, respectively. The hardness of the austenite matrix and the Rockwell hardness of heat-treated Fe-B alloy are higher than those of as-cast Fe-B alloy. In the erosioncorrosion test of the slurry, the erosion-corrosion weight loss of Fe-B alloy is lower than that of Cr28 white cast iron, indicating the Fe-B alloy displays higher erosion-corrosion resistance. | Da-wei Yi Yu-pu Shi Han-guang Fu Jin Chen Chong Li | 2019 | China Foundry2019，16，5： | 2 |
| 16 | BMP7 gene polymorphisms are not associated with bone mineral density or osteoporotic fractures in postmenopausal Chinese women显示文摘瞄准:以前的研究显示出那根骨头形态基因的蛋白质 7 (BMP7 ) 基因多型性在 920 个欧洲美国人与骨头矿物质密度(BMD ) 被联系。为了决定 BMP7 多型性和 BMD 和 osteoporotic 的协会,折断危险性,我们在绝经后的中国女人执行了盒子控制协会研究与或没有 osteoporotic fracture.Methods:3815 个无关的绝经后的中国女人的一个总数(1238 与 osteoporotic 骨折和 2577 健康控制) 被招募。腰部的脊骨 1-4 (L1-4 ) 和近似腿节(包括的全部的臀部和大腿骨的颈) 的 BMD 用双精力的 X 光检查 absorptiometry 被测量。包括 rs11086598, rs4811822, rs12481628, rs6025447, rs230205, rs17404303, rs162316 和 rs6127980,在 BMP7 基因的八标注单个核苷酸多型性(SNP ) 是 genotyped.Results:在 8 SNP 之中, rs6025447 和 rs230205 与全部的新潮的 BMD 被联系(P=0.013 并且 0.045,分别地) 。然而,协会在好久调整以后变得统计上不足道,高度和重量。BMP7 基因的 TGTG haplotype 与全部的新潮的 BMD (P=0.032 ) 被联系,甚至在好久调整以后,高度和重量(P=0.048 ) ;但是协会在执行 Bonferroni multiple-significance-test 修正以后是不足道的。而且, 8 SNP 和 BMP7 基因的 9 haplotypes 没与 L1-4 或大腿骨的颈 BMD 或 osteoporotic fracture.Conclusion 被联系:这大样品的盒子控制协会研究建议 BMP7 基因的普通基因多型性不是到在在绝经后的中国女人的 BMD 或 osteoporotic 骨折的变化的主要贡献者。 | Li-hong GAO Shan-shan LI Chong SHAO Wen-zhen FU Yu-juan LIU Jin-wei HE Zhen-lin ZHANG | 2016 | Acta Pharmacologica Sinica2016，37，8： | 2 |
| 17 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
| 18 | Laser Surface Remelting of Fe-based Alloy Coating Deposited by APS显示文摘The Fe-based amorphous alloy coatings with different porosities were deposited on Q235 steel substrates by means of atmospheric plasma spraying(APS).The as-sprayed coatings were remelted by the facility of a Nd:YAG laser to further enhance their compactness and bonding strength via orthogonal experiment design.The effects of laser remelting on the microstructure,phase compositions and mechanical properties of the as-sprayed coatings were investigated by optical microscopy,scanning electron microscope,X-ray diffraction and Vickers microhardness tester.The corrosion performance of the coatings was evaluated by both potential dynamic measurements(PDM)and electrochemical impedance spectroscopy(EIS)in a 10%NaOH solution.The results indicate that laser power of 700 W,scanning velocity of 4 mm/s,beam size of 3 mm and porosity of 1.19%are the optimized remelting process parameters.The laser-remelted coatings exhibite more homogenous structure as strong metallurgical bonding to substrates.The amorphous phases in the as-sprayed coatings crystallize toα-Fe,Fe2Si,Fe3.5B,and Fe2W phases for the high temperature and rapid solidification in the remelting process.The microhardness values of as-sprayed are in the range of 700-800 HV0.1,while the microhardness values of the remelted coatings are enhanced slightly to 750-850 HV0.1.Both PDM and EIS analysis results show that the remelted coatings exhibite relatively excellent corrosion resistance compared with the stainless steel 1Cr18Ni9Ti,however the corrosion resistance of the remelted coatings is inferior to the as-sprayed amorphous coatings. | Fu Teng Ye Fuxing Wei Haihong Cui Chong | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 19 | A chaos-based digitalimage encryption scheme with an improved diffusion strategy显示文摘 | FU Chong CHEN Jun-jie ZOU Hao | 2012 | Op-tics Express2012，20，3： | 1 |
| 20 | Direct access to β-seleno sulfones at room temperature through selenosulfonylation of alkenes显示文摘A new protocol has been developed for the formation of C.Se and C.S bonds by the direct selenosulfonylation of alkenes.This protocol is operationally simplistic, has a wide substrate scope, uses readily available seleno and sulfonyl sources, and is amenable to gram-scale synthesis. This reaction represents a significant addition to the limited number of reactions available for the intermolecular selenide difunctionalization of alkenes and would be useful for the synthesis of sulfur-and selenium-containing molecules. | Kai Sun Yunhe Lv Zuodong Shi Fangfang Fu Chong Zhang Zhiguo Zhang | 2017 | Science China Chemistry2017，60，6： | 1 |
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