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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Prospective comparison between double-balloon enteroscopy and spiral enteroscopy显示文摘 | T. Frieling J. Heise W. Sassenrath A. Hülsdonk C. Kreysel | 2010 | Endoscopy2010，，： | 2 |
| 3 | Benefits of laparoscopic peritoneal lavage for complicated sigmoid diverticulitis显示文摘 | Joanne Favuzza John C. Friel John J. Kelly Richard Perugini Timothy C. Counihan | 2009 | International Journal of Colorectal Disease2009，，7： | 2 |
| 4 | Agenetic association study of maternal and fetal candidate genes that predispose to preterm prelabor repture of membrances(PROM)显示文摘 | Romero R Friel LA Velez Edwards DR | 2010 | Am J Obstet Gynecol2010，203，4： | 1 |
| 5 | Energy-transfer upconversion and thermal lensing in highpower end-pumped Nd : YLiF4 laser crystals显示文摘 | HARDMAN P J CLARKSON W A FRIEL G J | 1999 | IEEE Journal of Quantum Electronics1999，35，4： | 1 |
| 6 | Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells显示文摘 | Friel AM Sergent PA Patnaude C | 2008 | Cell Cycle2008，7，2： | 1 |
| 7 | Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases显示文摘 | Von Herbay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 8 | Injury of the Posterior Ligamentous Complex of the Thoracolumbar Spine: A Prospective Evaluation of the Diagnostic Accuracy of Magnetic Resonance Imaging显示文摘 | Alexander R. Vaccaro Jeffrey A. Rihn Davor Saravanja David G. Anderson Alan S. Hilibrand Todd J. Albert Michael G. Fehlings William Morrison Adam E. Flanders John C. France Paul Arnold Paul A. Anderson Brian Friel David Malfair John Street Brian Kwon Scot | 2009 | Spine2009，，23： | 1 |
| 9 | An em- pirical model to predict the headspace concentration of volatile compounds above solutions containing sucrose 显示文摘 | FRIEL E N LINFORTH R S T TAYLOR A J | 2000 | Food Chemistry2000，71，3： | 1 |
| 10 | Hypocaloric total parenferal nutrition: effectiveness in prevention nf hyperglycemia and infectious complicatinnsa randomized clinical trial 显示文摘 | MeCowen KC Friel C Sternberg J | 2000 | Crit Care Med2000，28，1： | 1 |
| 11 | Hypocaloric total parenteral nutrition: effectiveness in prevention of hyperglycemia and infectious complications,a randomized clinical trial 显示文摘 | McCowen KC Friel C Sternberg J | 2000 | Crit Care Med2000，28，11： | 1 |
| 12 | Resolution of hydatid liver cyst by spontaneous rupture into the biliary tract显示文摘 | Becker K Frieling T Saleh A | 1997 | J Hepatol1997，26，6： | 1 |
| 13 | Histamine receptors on submucous neurons in guinea pig colon显示文摘 | Frieling T Cooke I/J Wood JD | 1993 | Am J Physiol1993，264，11： | 1 |
| 14 | Prevention of adhesions in surgery of the flexor tendons of the hand: what is the evidence? 显示文摘 | Khanna A Friel M Gougoulias N | 2009 | Br Med Bull2009，90，： | 1 |
| 15 | Six- teen year atmospheric corrosion performance of weathe- ring steels in marine, rural and industrial environments 显示文摘 | SHASTRY C R FRIEL J J TOWNSEND H E | 1988 | Degradation of Metals in Atmosphere1988，，： | 1 |
| 16 | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis显示文摘 | RIZZOLI R LAROCHE M A FRIELING I | 2010 | Rheumatology international2010，30，10： | 1 |
| 17 | EEG biofeedback in the treatment of Attention Deficit/Hyperactivity Disorder 显示文摘 | Patrick N Friel B S | 2007 | Alternative Medicine Review2007，12，2： | 1 |
| 18 | Morphometry of the ciliary body using ultrasound biomicroscopy 显示文摘 | Frieling E Dembinsky B | 1995 | Ophthalmologe1995，92，5： | 1 |
| 19 | Prospective study on the detection of insulinomas by EUS显示文摘 | Shumacher B Lubke J Frieling T | 1996 | Faldoscopy1996，28，： | 1 |
| 20 | Relevance of cir-culating tumor cells, extracellular nucleic acids and exosome inbreast cancer显示文摘 | Friel A M Corcoran C Crown J 0 Driscoll L | 2010 | Breast Cancer Res Treat2010，123，3： | 1 |
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