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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Prevention of adhesions in surgery of the flexor tendons of the hand: what is the evidence? 显示文摘 | Khanna A Friel M Gougoulias N | 2009 | Br Med Bull2009，90，： | 1 |
| 3 | Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis显示文摘 | RIZZOLI R LAROCHE M A FRIELING I | 2010 | Rheumatology international2010，30，10： | 1 |
| 4 | Relevance of cir-culating tumor cells, extracellular nucleic acids and exosome inbreast cancer显示文摘 | Friel A M Corcoran C Crown J 0 Driscoll L | 2010 | Breast Cancer Res Treat2010，123，3： | 1 |
| 5 | Rho AlRho kinase mRNA and protein levels in human myometrium during pregnancy and lahor显示文摘 | Friel AM Curley M Ravikumar N | 2005 | J Soc Gynecol Investig2005，12，1： | 1 |
| 6 | Intracellular and extracellular microRNAs in breast cancer显示文摘 | Corcoran C Friel AM Duffy M J | 2011 | Clin Chem2011，57，1： | 1 |
| 7 | Prevention of adhesions in surgery of the flexor tendons of the hand= what is the evidence? 显示文摘 | Khanna A Friel M Gougoulias N | 2009 | Br Med Bull2009，90，： | 1 |
| 8 | Circulating interleukin 6 receptor in patients with sepsis syndrome显示文摘 | FRIELING J T VAN DEUREN M WIJDENES J | 1995 | J Infect Dis1995，171，2： | 1 |
| 9 | Milk from mothers of both premature and full-term infants provides better antioxidant protection than does infant formula显示文摘 | Friel JK Martin SM Langdon M | 2002 | Pediatr Res2002，51，5： | 1 |
| 10 | Rho A/Rho kinase mRNA and protein levels in human myometrium during pregnancy and labor 显示文摘 | Friel A M Curley M Ravikumar N | 2005 | Soc Gynecol Investiq2005，12，1： | 1 |
| 11 | Differential activity-dependent development of cortieo spinal control of movement and final limb position during visually-guided locomotion显示文摘 | Friel K M Drew T Martin J H | 2007 | J Neurophysiol2007，97，5： | 1 |
| 12 | The measure of face-lift patient satisfaction: the Owsley Facelift Satisfaction Survey with long- term follow-up study显示文摘 | FRIEL M T SHAW R E TROVATO M J | 2010 | Plast Reconstr Surg2010，126，1： | 1 |
| 13 | Intraeellular and extracellular micrornas in breast cancer显示文摘 | CORCORAN C FRIEL A M DUFFY M J | 2011 | Clin Chem2011，57，： | 1 |
| 14 | Rel- evance of cireulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer显示文摘 | FRIEL A M CORCORAN C CROWN J | 2010 | Breast Canc Res Treat2010，123，： | 1 |
| 15 | Local excision of T1 rectal cancer:where are we now显示文摘 | Charles M Friel M | | 0，，09： | 1 |
| 16 | Frequency and magnitude of debris flows on Cheekye River, British Columbia 显示文摘 | Jakob M Friele P | 2010 | Geomorphology2010，114，3： | 1 |
| 17 | Closing the gap in ageneration: health equity through action on the social deter-minants of health 显示文摘 | Marmot M Friel S Bell R | 2008 | Lancet2008，372，9650： | 1 |
| 18 | Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium显示文摘 | Curley M Cairn M T Friel A M McMeel O M Morrison J J Smith T J | 2002 | Mol Hum Reprod2002，8，： | 1 |
| 19 | Preliminary study of articulatory reorganisation of fricative consonants following osteotomy 显示文摘 | Isaacson KG Friel S | 1996 | Folia Phoniatr Logop1996，48，6： | 1 |
| 20 | Mitotic centromere-as- sociated kinesin ( MCAK ) : a potential cancer drug target 显示文摘 | Sanhaji M Friel CT Wordeman L | 2011 | Oncotarget2011，2，12： | 1 |
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