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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease显示文摘 | Adam M Zahm Meena Thayu Nicholas J Hand Amber Horner Mary B Leonard Joshua R Friedman | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，1： | 3 |
| 3 | Clinical and scientific impact of human papillomavirus on head and neck cancer显示文摘Head and neck cancer(HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the combination of the two produced a synergistic increase in risk. However, beginning in 1983, investigators have found a significant and growing proportion of HNC patients with human papillomavirus-positive(HPV) tumors who neither drank nor used tobacco. Since that time, there has been increased interest in the molecular biology of HPV-positive HNC. Multiple studies now show that HPV has shifted the epidemiological landscape and prognosis of head and neck squamous cell carcinoma(HNSCC). These studies provide strong evidence for improved survival outcomes in patients with HPV-positive HNSCC compared to those with HPV-negative HNSCC. In many reports, HPV status is the strongest predictor of locoregional control, disease specific survival and overall survival. In response to these findings, there has been significant interest in the best management of HPV-positive disease. Discussions within major cooperative groups consider new trials designed to maintain the current strong survival outcomes while reducing the long-term treatment-re-lated toxicities. This review will highlight the epidemiological, clinical and molecular discoveries surrounding HPV-related HNSCC over the recent decades and we conclude by suggesting how these findings may guide future treatment approaches. | Jeffrey M Friedman Mark J Stavas Anthony J Cmelak | 2014 | World Journal of Clinical Oncology2014，5，4： | 3 |
| 4 | Fetal cardiac function assessed by Doppler myocardial performance index (Tei index)显示文摘 | Friedman D Buyon J Kim M | 2003 | Ultrasound Obstet Gynecol2003，21，1： | 2 |
| 5 | Zpalatoplasty (ZPP): a technique for patients without tonsils 显示文摘 | Friedman M lbrahim HZ Vidvasagar R Pomeranz J | 2004 | Otolaryngol Head Neck Surg2004，131，： | 1 |
| 6 | Post-traumatic cerebrospinal fluid leakage显示文摘 | Friedman J A Ebersold M J Quast L M | 2001 | World J Surg2001，25，8： | 1 |
| 7 | The Utility Analysis of Choice Involving Risk显示文摘 | Friedman M Savage L J | 1948 | Journal of Political Economy1948，56，27： | 1 |
| 8 | Post-traumatic cerebrospinal fluid leakage显示文摘 | Friedman JA Ebersold M J Quast LM | 2003 | World J Surg2003，25，8： | 1 |
| 9 | Precise age of the platiniferous Me- rensky reef, Bushveld complex, south Africa, by the U-Pb zir- con chemical abrasion ID-TIMS technique 显示文摘 | Scoates J S Friedman R M | 2008 | Economic Geolo- gy2008，103，3： | 1 |
| 10 | Prevalence and clinical characteristics of glaucoma in adult Chi- nese:a population-based study in Liwan District, Guangzhou 显示文摘 | He M Foster P J Ge J Huang W Zheng Y Friedman DS | 2005 | Invest Ophthalmol Vis Sci2005，47，7： | 1 |
| 11 | Triggering and evolu- tion of a giant submarine landslide, offshore Angola, revealed by 3D seismic stratigraphy and geomorphology显示文摘 | Gee M Gawthorpe R L Friedman J S | 2006 | Journal of Sedimentary Research2006，76，1： | 1 |
| 12 | Mechanical, barrier, and antimicrobial properties of apple puree edible films containing plant essential oils显示文摘 | Rojas-Grau M A Avena-Bustillos R J Friedman M | 2006 | Journal of Agricultural and Food Chemistry2006，54，24： | 1 |
| 13 | Ego-identity status in college women显示文摘 | Marcia J E Friedman M F | 1970 | Journal of Personality1970，38，： | 1 |
| 14 | The establishment of an academic nursing faculty: action research in Israel显示文摘 | Arieli D Friedman V J Hirschfeld M J | 2009 | Int Nurs Rev2009，56，3： | 1 |
| 15 | Effect of potato glycoalkaloidvS crchaconine and crsolanine on sodium active trans-port in frog skin显示文摘 | Blankemeyer J Atherton R Friedman M | 1995 | Journal of Agricultural and Food Chemisty1995，43，： | 1 |
| 16 | Gonioscopy in adult Chinese : the Liwan Eye Study 显示文摘 | He M Foster P J Ge J Huang W Wang W Friedman DS | 2005 | Invest Ophthalmol Vis Sci2005，47，11： | 1 |
| 17 | Effect of improved nasal breathing on obstructive sleep apnea显示文摘 | FRIEDMAN M TANYERI H LIM J W | 2000 | Otolaryngol Head Neck Surg2000，122，： | 1 |
| 18 | Intravascular thrombosis in central nervous system malignancies: a potential role in astroeytoma progression to glioblastoma 显示文摘 | TEHRANI M FRIEDMAN T M OLSON J J | 2008 | Brain Pathol2008，18，2： | 1 |
| 19 | Desmopressin in the treat- ment of nocturia: clinical evidence and experience 显示文摘 | Friedman F M Weiss J P | 2013 | Ther Adv Urol2013，5，6： | 1 |
| 20 | Efficient generation of multi-gigawatt RF power by a klystron-like amplifier显示文摘 | Friedman M Krall J Lau Y Y | 1990 | Rev Sci Instrum1990，61，1： | 1 |
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