|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease显示文摘 | Adam M Zahm Meena Thayu Nicholas J Hand Amber Horner Mary B Leonard Joshua R Friedman | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，1： | 3 |
| 3 | Clinical and scientific impact of human papillomavirus on head and neck cancer显示文摘Head and neck cancer(HNC) arises from the skull base to the clavicles and is the fifth most common cancer in the world by incidence. Historically, in the developed world HNC was associated with tobacco use and alcohol consumption, and the combination of the two produced a synergistic increase in risk. However, beginning in 1983, investigators have found a significant and growing proportion of HNC patients with human papillomavirus-positive(HPV) tumors who neither drank nor used tobacco. Since that time, there has been increased interest in the molecular biology of HPV-positive HNC. Multiple studies now show that HPV has shifted the epidemiological landscape and prognosis of head and neck squamous cell carcinoma(HNSCC). These studies provide strong evidence for improved survival outcomes in patients with HPV-positive HNSCC compared to those with HPV-negative HNSCC. In many reports, HPV status is the strongest predictor of locoregional control, disease specific survival and overall survival. In response to these findings, there has been significant interest in the best management of HPV-positive disease. Discussions within major cooperative groups consider new trials designed to maintain the current strong survival outcomes while reducing the long-term treatment-re-lated toxicities. This review will highlight the epidemiological, clinical and molecular discoveries surrounding HPV-related HNSCC over the recent decades and we conclude by suggesting how these findings may guide future treatment approaches. | Jeffrey M Friedman Mark J Stavas Anthony J Cmelak | 2014 | World Journal of Clinical Oncology2014，5，4： | 3 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | Fetal cardiac function assessed by Doppler myocardial performance index (Tei index)显示文摘 | Friedman D Buyon J Kim M | 2003 | Ultrasound Obstet Gynecol2003，21，1： | 2 |
| 6 | Bactericidal oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes and Salmonella enterica 显示文摘 | Friedman M Henika PR activities of plant essential Mandrell RE | 2002 | J Food Prot2002，65，10： | 1 |
| 7 | Social support resources and psychological well-being in older women with heart disease显示文摘 | FRIEDMAN M M | 1993 | Res Nurs Health1993，16，6： | 1 |
| 8 | A lifetime oncogenicity study in rats with acrylamide 显示文摘 | FRIEDMAN M A DULAK L H STEDHAM M A | 1995 | Fundam Appl Toxicol1995，27，1： | 1 |
| 9 | Bayesian network classifiers显示文摘 | FRIEDMAN N GEIGER D GOLDSZMIDT M | 1997 | Machine Learning1997，29，3： | 1 |
| 10 | Deep-burial dolomitization in the Ordovician Ellenburger Group carbonates,West Texas and Southeastern New Mexico显示文摘 | Lee Y I Friedman G M | 1987 | Journal of Sedimentary Research1987，57，3： | 1 |
| 11 | Zpalatoplasty (ZPP): a technique for patients without tonsils 显示文摘 | Friedman M lbrahim HZ Vidvasagar R Pomeranz J | 2004 | Otolaryngol Head Neck Surg2004，131，： | 1 |
| 12 | Using Bayesian networks to analyze expression data 显示文摘 | FRIEDMAN N LINIAL M NACHMAN I | 2000 | Journal of Computational Biology2000，7，3： | 1 |
| 13 | Processing demands in belief-desire reasoning:inhibition or general difficulty显示文摘 | Ori Leslie Alan M | 2005 | Developmental Science2005，8，3： | 1 |
| 14 | Post-traumatic cerebrospinal fluid leakage显示文摘 | Friedman J A Ebersold M J Quast L M | 2001 | World J Surg2001，25，8： | 1 |
| 15 | The Utility Analysis of Choice Involving Risk显示文摘 | Friedman M Savage L J | 1948 | Journal of Political Economy1948，56，27： | 1 |
| 16 | Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts 显示文摘 | Harada K Grossman W Friedman M | 1994 | J Clin Invest1994，94，： | 1 |
| 17 | Post-traumatic cerebrospinal fluid leakage显示文摘 | Friedman JA Ebersold M J Quast LM | 2003 | World J Surg2003，25，8： | 1 |
| 18 | Increased skeletal muscle tumor necrosis factor - alpha and impaired insulin signaling persist in obese with gestational diabetes mellitus 1 year postpartum 显示文摘 | Friedman JE Kirwan JP Jing M | 2008 | Diabetes2008，57，3： | 1 |
| 19 | The social responsibility of business is to increase its profits显示文摘 | Friedman M | 1970 | The New York Times Magazine1970，，： | 1 |
| 20 | The anticariogenic effect of amine fluorides on streptococcus sobrinus and glucosyhransferase in biofilms 显示文摘 | Sharti S Friedman M Steinberg D | 2000 | Caries Res2000，34，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员