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| 1 | Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities显示文摘背景 WWOX 和 FHIT 是位于活跃易碎的地点,其损坏与乳癌的发展被联系了的二候选人肿瘤 suppressor 基因。这些基因的表达式和乳癌的开发的协会充分没被探索。我们与正常组织学的外观在胸织物评估了 mRNA 和 WWOX 和 FHIT 的蛋白质表示,不正常的 ductal 增生,在 situ 的 ductal 癌,并且看在表示的进步衰落是否是 present.Methods 颠倒抄写聚合酶链反应并且西方的弄污的侵略癌症被用来为 mRNA 和蛋白质表示评估标本包括有正常织物的 28 个标本,有不正常的 ductal 增生的 28 个标本,有 ductal 的 33 个标本汽车结果与相比在 situ 和侵略癌症标本,正常、不正常的增生标本有可检测的 mRNA 的更大的率(WWOX 率 ratio=2.95, 95% CI 1.24-7.08;FHIT 率 ratio=4.58, 95% Cl 1.82-11.81 ) 并且西方的弄污的可检测的蛋白质(WWOX 率 ratio=4.12, 95% Cl 1.63-10.73;FHIT 率 ratio=3.76, 95% Cl 1.44-10.06 ) 。为两蛋白质,正常、不正常的增生标本之间并且在之间的差别在 situ 和侵略的癌,标本碰巧是可解说的(P > 0.05 为每分析) 。在每个组织学的范畴以内,在标本的部分之中的差别显示出那 FHIT 和 WWOX mRNA。并且蛋白质表示碰巧是可解说的(P > 0.05 为每分析) FHIT 和 WWOX 的 .Conclusion 表示从正常组织学的外观与胸织物进步一起减少到不正常的 ductal 增生在 situ 癌症,并且最后的侵略癌症。 | WANG Tian-tian Eldo E Frezza MA Rong HU San-yuan LIU Chong-zhong ZHANG Guang-yong Mitchell S. Wachtel LU Xiao-mei FENG Jin-bo LU Cui-xia | 2008 | Chinese Medical Journal2008，，20： | 2 |
| 2 | Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma : validation of utility as a clinical marker 显示文摘 | Goydos JS Brumfield AM Frezza E | 1998 | Ann Surg1998，227，2： | 1 |
| 3 | Crural repair permits morbidly obese patients with not large hiatal hernia to choose laparoscopic adjustable banding as a bariatric surgical treatment显示文摘 | Frezza E E Barton A Wachtel M S | 2008 | Obes Surg2008，18，5： | 1 |
| 4 | Defects in mitochondrial metabolism and cancer显示文摘 | Gaude E Frezza C | 2014 | Cancer Metab2014，2，： | 1 |
| 5 | Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker 显示文摘 | Goydos JS Brumfield AM Frezza E | 1998 | Ann Surg1998，227，3： | 1 |
| 6 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 7 | Mitochondria in cancer: not just innocent bystanders显示文摘 | Frezza C Gottlieb E | 2009 | Semin Cancer Biol2009，19，1： | 1 |
| 8 | High blood alcohollevels in women, the role of decreased gastric alcohol dehydrogenase activity andfirst-pass metabolism显示文摘 | Frezza M DiPadova C Pozzato G Terpin M Baraona E Lieber CS | 1990 | New Eng J Med1990，322，： | 1 |
| 9 | Marked elevation of surum interlenkin -6 in patients with cholangiocarcinoma validation of utility as a clinical marker显示文摘 | Goydos JS Brumfield AM Frezza E | 1998 | Ann Surg1998，227，3： | 1 |
| 10 | Mitochondria in cancer: not just innocent bystanders 显示文摘 | Frezza C Gottlieb E | 2009 | Semin Cancer Biol2009，19，1： | 1 |
| 11 | 查看详情显示文摘 | FREZZA C GOTTLIEBo E | | 0，，： | 1 |
| 12 | Analysis of the results of sleeve gastrectomy for morbid obesity and the role of ghrelin 显示文摘 | Frezza E Chiriva-lnternati M Wachtel M | 2008 | Surg Today2008，38，6： | 1 |
| 13 | Habitatuse, urea production and spawning in the gulf toadfish Opsanus beta显示文摘 | BARIMO J F SERAFY J E FREZZA P E | 2007 | Marine Biology2007，150，3： | 1 |
| 14 | Mitochondria in cancer: not just innocent bystanders 显示文摘 | Frezza C Gottlieb E | 2009 | Semin Cancer Biol2009，19，1： | 1 |
| 15 | Prospective randomized study of stapled versus unstapled mesh in a laparoseopie preperitoneal inguinal hernia repair显示文摘 | Ferzli G S Frezza E E Pecoraro A M Jr Ahern K D | 1999 | J Am Coll Surg1999，188，： | 1 |
| 16 | Marked elevstion of serum inter leukin-6 in patients with cholangiocarcinoma validation of utility as a clinical marker显示文摘 | Goydos JS Brumfield AM Frezza E | | Ann Sery l998 277(3)0，398，： | 1 |
| 17 | Inborn and acquired metabolic defects in cancer显示文摘 | Frezza C Pollard PJ Gottlieb E | 2011 | J Mol Meal (Berl)2011，89，3： | 1 |
| 18 | Minimal debridement in the treatment of Fournier's gangrene显示文摘 | FREZZA E E ATLAS I | 1999 | Am Surg1999，65，11： | 1 |
| 19 | Marked elevation of interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker显示文摘 | Goydos JS Brumfield AM Frezza E | 1998 | Ann Surg1998，227，3： | 1 |
| 20 | Mi- tochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency显示文摘 | COGLIATI S FREZZA C SORIANO M E | 2013 | Cell2013，155，： | 1 |
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