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| 1 | Global cancer statistics, 2012显示文摘 | Lindsey A. Torre Freddie Bray Rebecca L. Siegel Jacques Ferlay Joannie Lortet‐Tieulent Ahmedin Jemal | 2015 | CA: A Cancer Journal for Clinicians2015，，2： | 53 |
| 2 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Int. J. Cancer2015，，5： | 31 |
| 3 | 前交叉韧带解剖重建理念与方法显示文摘前交叉韧带(Anterior Cruciate Ligament,ACL)解剖重建技术是基于ACL解剖理论发展起来的一项手术技术。ACL解剖重建是根据ACL的解剖特点进行功能重建,恢复ACL原有的尺寸、韧带胶原走行方向和止点位置。解剖重建不仅包括双束和单束重建,而且包括以此理论为基础的ACL重建术后的翻修与加固。本文对ACL的解剖重建技术进行介绍,针对在关节镜下如何观察原ACL的止点位置,测量止点长宽,选择骨道位置,如何利用影像学进行评价进行了详细的阐述和解释,并介绍了该技术目前的临床评价结果。同时,本文对ACL解剖重建和传统'经典'重建方法的区别进行了重点说明与解释,为提高国内医师对ACL解剖重建技术的认识提供参考和帮助。 | 周敬滨 Zachary Working Carola F.van Eck Freddie H.Fu | 2011 | 中国运动医学杂志2011，30，6： | 34 |
| 4 | 提高苹果基因转化效率的研究显示文摘采用根瘤农杆菌(Agrobacterium tumefaciens)强株系EHA105(p35sGUS-intron)研究了影响‘皇家嘎拉’苹果(Mains domestica Borkh.)外植体的β-葡萄糖醛酸酶(GUS)基因的瞬时、稳定表达水平和转基因植株的再生。证明在培养基生长素(IBA、NAA)存在的条件下,外植体的GUS基因的瞬时表达水平提高了3-4倍,而共培养两周后稳定表达水平提高2倍以上,产生9.8个GUS愈伤组织表达区域。白化处理促进外植体的基因转化,白化处理的新梢顶端第一节间外植体GUS表达区域比常用的叶片外植体高4倍。在生长素存在的条件下 2%外植体获得了转基因植株。Southern BlotDNA杂交和组织化学染色分析证明GUS基因已整合到苹果的染色体上,并得以表达。 | 刘庆忠 赵红军 Freddi Hammerschlag | 2000 | 果树科学2000，17，3： | 24 |
| 5 | “猪地方性肺炎及其防治控制”专栏二:有关猪肺炎支原体感染诊断方法和流行病学的最新观点显示文摘猪肺炎支原体是猪地方性肺炎(Enzoodc Pneumonia,EP)的主要病原体,本病是一种主要影响肥育猪的慢性呼吸道疾病。尽管人们在控制猪肺炎支原体感染及其带来的不利影响上花费了大量的精力,但是猪地方性肺炎仍继续给全球养猪生产造成重大的经济损失。猪肺炎支原体通常是通过引进亚临床型感染的动物而侵入猪群的,或通过短距离的空气传播发生感染,但后一种情况较少。一旦侵入猪群,猪肺炎支原体可通过与受感染的母猪直接接触而将病原体传给后代或在同圈猪只之间进行传播。用于诊断猪肺炎支原体感染的“黄金标准”技术——细菌学培养非常费劲,通常很少使用。酶联免疫吸附试验和聚合酶链式反应检测方法以及以屠宰场监测或田间剖解为形式的死后检查,是用于调查猪肺炎支原体是否参与了猪呼吸道疾病的最常用技术。这些技术已被用来监测受猪地方性肺炎影响的猪群猪肺炎支原体的临床型和亚临床型感染猪群、免疫猪群或非免疫猪群以及处于不同的生产条件和管理奈件下的猪群的发生情况。猪场水平上的猪地方性肺炎临床过程差异以及猪肺炎支原体疫苗接种效果的差异表明,猪肺炎支原体的不同田间分离株的传播和毒力特性存在差异。本文综述了猪肺炎支原体感染的流行病学最新知识,包括其传播、感染和血清转化动力学,并且还比较了用来监测猪地方性肺炎的各种流行病学方法。 | Marina Sibila Maria Pieters Thomas Molitor Dominiek Maes Freddy Haesebmuck Joaquim Segal e s 沈权(译) 邵嘉佳(校) | 2009 | 国外畜牧学(猪与禽)2009，，3： | 16 |
| 6 | SJWD14121600000297显示文摘 | Jacques Ferlay Isabelle Soerjomataram Rajesh Dikshit Sultan Eser Colin Mathers Marise Rebelo Donald Maxwell Parkin David Forman Freddie Bray | 2015 | Cancer2015，，5： | 15 |
| 7 | Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk:a meta-analysis of prospective studies显示文摘Background:The temporal relationship between hepatitis B virus(HBV) mutations and hepatocellular carcinoma(HCC) remains unclear.Methods:We conducted a meta-analysis including cohort and nested case-control studies to prospectively examine the HCC risk associated with common variants of HBV in the PreS,Enhancer II,basal core promoter(BCP) and precore regions.Pertinent studies were identified by searching PubMed,Web of Science and the Chinese Biological Medicine databases through to November 2014.Study-specific risk estimates were combined using fixed or random effects models depending on whether significant heterogeneity was detected.Results:Twenty prospective studies were identified,which included 8 cohort and 12 nested case-control studies.There was an increased risk of HCC associated with any PreS mutations with a pooled relative risk(RR) of 3.82[95% confidence interval(CI):2.59-5.61].The pooled-RR for PreS deletion was 3.98(95%CI:2.28-6.95),which was higher than that of PreS2 start codon mutation(pooled-RR=2.63,95%CI:1.30-5.34).C1653 T in Enhancer Ⅱ was significantly associated with HCC risk(pooled-RR=1.83;95%CI:1.21-2.76).For mutations in BCP,statistically significant pooled-RRs of HCC were obtained for T1753V(pooledRR=2.09;95%CI:1.49-2.94) and A1762T/G1764 A double mutations(pooled-RR=3.11;95%CI:2.08-4.64).No statistically significant association with HCC risk was observed for G1896 A in the precore region(pooled-RR=0.77;95%CI:0.47-1.26).Conclusions:This study demonstrated that PreS mutations,C1653 T,T1753V,and A1762T/G1764 A,were associated with an increased risk of HCC.Clinical practices concerning the HCC risk prediction and diagnosis may wish to focus on patients with these mutations. | Yang Yang Jiang-Wei Sun Long-Gang Zhao Freddie Bray Yong-Bing Xiang | 2015 | Chinese Journal of Cancer Research2015，27，5： | 7 |
| 8 | 中国北京和长岛大气颗粒物中铅的同位素丰度比测定(英文)显示文摘采用高分辨电感耦合等离子体质谱技术(HRICPMS)分析了48个不同季节大气气溶胶颗粒样品中铅同位素丰度(A)比值,为中国城市铅污染源研究提供数据。样品采自中国北京和山东长岛地区(2002~2003年期间不同季节)。A(206Pb/207Pb)和A(208Pb/207Pb)的10次测定精密度为0.05%~0.19%RSD。 | 李冰 刘咸德 董树屏 Veerle Van Lierde Frank Vanhaecke Freddy C Adams | 2005 | 岩矿测试2005，24，1： | 5 |
| 9 | 用扫描电镜分析表征大气气溶胶单颗粒(英文)显示文摘Scanning electron microscope energy dispersive X ray analysis system (SEM EDX) is able to provide analytical data for each single particle. Hundreds of particles are usually analyzed for an aerosol sample. Both physical and chemical characterization can be performed in terms of particle size and particle class compositional data, respectively. Mineral dusts such as aluminosilicates and quartz particles as well as sea salt particles featured coarse fractions. Fine fractions were dominated by various sulfur containing and carbonaceous particles. | 刘咸德 董树屏 李玉武 Freddy Adams | 2003 | 环境化学2003，22，3： | 5 |
| 10 | Global cancer transitions according to the Human Development Index (2008–2030): a population-based study显示文摘 | Freddie Bray Ahmedin Jemal Nathan Grey Jacques Ferlay David Forman | 2012 | Lancet Oncology2012，，8： | 4 |
| 11 | Controlled trial of metronidazole treatment for prevention of crohn’s recurrence after ileal resection显示文摘 | Paul Rutgeerts Martin Hiele Karel Geboes Marc Peeters Freddy Penninckx Raymond Aerts Raymond Kerremans | 1995 | Gastroenterology1995，，6： | 4 |
| 12 | Electrocardiographic markers of cardiac resynchronization therapy response:delayed time to intrinsicoid deflection onset in lateral leads显示文摘Cardiac resynchronization therapy(CRT)has emerged as an important intervention for patients with heart failure(HF)with reduced ejection fraction and delayed ventricular activation.In these patients,CRT has demonstrated to improve quality of life,promote reverse left ventricular(LV)remodeling,reduce HF hospitalizations,and extend survival.However,despite advancements in our understanding of CRT,a significant number of patients do not respond to this therapy.Several invasive and non-invasive parameters have been assessed to predict response to CRT,but the electrocardiogram(ECG)has remained as the prevailing screening method albeit with limitations.Ideally,an accurate,simple,and reproducible ECG marker or set of markers would dramatically overcome the current limitations.We describe the clinical utility of an old ECG parameter that can estimate ventricular activation delay:the onset to intrinsicoid deflection(ID).Based on the concept of direct measurement of ventricular activation time(intrinsic deflection onset),time to ID onset measures on the surface ECG the time that the electrical activation time takes to reach the area subtended by the corresponding surface ECG lead.Based on this principle,the time to ID on the lateral leads can estimate the delay activation to the lateral LV wall and can be used as a predictor for CRT response,particularly in patients with non-specific intraventricular conduction delay or in patients with left bundle branch block and QRS<150 ms.The aim of this review is to present the current evidence and potential use of this ECG parameter to estimate LV activation and predict CRT response. | Rubén KA Tapia-Orihuela S Michael Gharacholou Samuel J Asirvatham Freddy Del-Carpio Munoz | 2022 | Journal of Geriatric Cardiology2022，19，1： | 3 |
| 13 | Global burden of cancers attributable to infections in 2008: a review and synthetic analysis显示文摘 | Catherine de Martel Jacques Ferlay Silvia Franceschi Jér?me Vignat Freddie Bray David Forman Martyn Plummer | 2012 | Lancet Oncology2012，，6： | 3 |
| 14 | The influence of bacteria on multitrophic interactions among plants, psyllids, and pathogen显示文摘 | Cecilia Tamborindeguy Ordom Brian Huot Freddy Ibanez Julien Levy | 2017 | Insect Science2017，24，6： | 3 |
| 15 | Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions显示文摘 | Isabelle Soerjomataram Joannie Lortet-Tieulent D Maxwell Parkin Jacques Ferlay Colin Mathers David Forman Freddie Bray | 2012 | The Lancet2012，，9856： | 3 |
| 16 | Global Burden of Human Papillomavirus and Related Diseases显示文摘 | David Forman Catherine de Martel Charles J. Lacey Isabelle Soerjomataram Joannie Lortet-Tieulent Laia Bruni Jerome Vignat Jacques Ferlay Freddie Bray Martyn Plummer Silvia Franceschi | 2012 | Vaccine2012，，： | 2 |
| 17 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 18 | Review of the malaria epidemiology and trends in Zambia显示文摘A comprehensive desk review of malaria trends was conducted between 2000-2010 in Zambia to study malaria epidemiology and trends to guide strategies and approaches for effective malaria control.This review considered data from the National Health Information Management System,Malaria Surveys and Programme Review reports and analyzed malaria in-patient cases and deaths in relation to intervention coverage for all ages.Data showed three distinct epidemiological strata after a notable malaria reduction(66%)in in-patient cases and deaths,particularly between 2000-2008.These changes occurred following the(re-)introduction and expansion of indoor residual spraying up to 90%coverage,scale-up of coverage of long-lasting insecticidetreated nets in household from 50%to 70%,and artemisin-based combination therapy nationwide.However,malaria cases and deaths re-surged,increasing in 2009-2010 in the northern-eastern parts of Zambia.Delays in the disbursement of funds affected the implementation of interventions,which resulted in resurgence of cases and deaths.In spite of a decline in malaria disease burden over the past decade in Zambia,a reversal in impact is notable in the year 2009-2010,signifying that control gains are fragile and must be sustained toeliminate malaria. | Freddie Masaninga Emmanuel Chanda Pascalina Chanda-Kapata Busiku Hamainza Hieronymo T Masendu Mulakwa Kamuliwo Wambinji Kapelwa John Chimumbwa John Govere Mac Otten Ibrahima Soce Fall Olusegun Babaniyi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 2 |
| 19 | Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells显示文摘 | Luca Pellegrinet Veronica Rodilla Zhenyi Liu Shuang Chen Ute Koch Lluis Espinosa Klaus H. Kaestner Raphael Kopan Julian Lewis Freddy Radtke | 2011 | Gastroenterology2011，，4： | 2 |
| 20 | Risk prediction models for hepatocellular carcinoma in different populations显示文摘Hepatocellular carcinoma(HCC) is a malignant disease with limited therapeutic options due to its aggressive progression. It places heavy burden on most low and middle income countries to treat HCC patients. Nowadays accurate HCC risk predictions can help making decisions on the need for HCC surveillance and antiviral therapy. HCC risk prediction models based on major risk factors of HCC are useful and helpful in providing adequate surveillance strategies to individuals who have different risk levels. Several risk prediction models among cohorts of different populations for estimating HCC incidence have been presented recently by using simple, efficient, and ready-to-use parameters. Moreover, using predictive scoring systems to assess HCC development can provide suggestions to improve clinical and public health approaches, making them more cost-effective and effort-effective, for inducing personalized surveillance programs according to risk stratification. In this review, the features of risk prediction models of HCC across different populations were summarized, and the perspectives of HCC risk prediction models were discussed as well. | Xiao Ma Yang Yang Hong Tu Jing Gao Yu-Ting Tan Jia-Li Zheng Freddie Bray Yong-Bing Xiang | 2016 | Chinese Journal of Cancer Research2016，28，2： | 2 |
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