4篇
您的检索式：作者名="Francesca Savini"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Medical treatment for gastro-entero-pancreatic neuroendocrine tumours显示文摘Gastro-entero-pancreatic neuroendocrine neoplasms(GEPNENs) represents a various family of rare tumours. Surgery is the first choice in GEP-NENs patients with localized disease whilst in the metastatic setting many other treatment options are available. Somatostatin analogues are indicated for symptoms control in functioning tumours. Furthermore they may be effective to inhibit tumour progression. GEP-NENs pathogenesis has been extensively studied in the last years therefore several driver mutations pathway genes have been identified as crucial factors in their tumourigenesis. GEP-NENs can over-express vascular endothelial growth factor(VEGF), basic-fibroblastic growth factor, transforming growth factor(TGF-α and-β), platelet derived growth factor(PDGF), insulin-like growth factor-1(IGF-1) and their receptors PDGF receptor, IGF-1 receptor, epidermal growth factor receptor, VEGF receptor, and c-kit(stem cell factor receptor) that can be considered as potential targets. The availability of new targeted agents, such as everolimus and sunitinib that are effective in advanced and metastatic pancreatic neuroendocrine tumours, has provided new treatment opportunities. Many trials combing new drugs are ongoing. | Rossana Berardi Francesca Morgese Mariangela Torniai Agnese Savini Stefano Partelli Silvia Rinaldi Miriam Caramanti Consuelo Ferrini Massimo Falconi Stefano Cascinu | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | Comparison Between Coronary Angioplasty and Coronary Artery Bypass Surgery for the Treatment of Unprotected Left Main Coronary Artery Stenosis (the Bologna Registry)显示文摘 | Tullio Palmerini Antonio Marzocchi Cinzia Marrozzini Paolo Ortolani Francesco Saia Carlo Savini Letizia Bacchi-Reggiani Silvia Gianstefani Santo Virzì Francesca Manara Meron Kiros Weldeab Giuseppe Marinelli Roberto Di Bartolomeo Angelo Branzi | 2006 | The American Journal of Cardiology2006，，1： | 1 |
| 3 | The Archaeoseismology of Historical Buildings: A Model Study from the L'Aquila Area in Italy显示文摘 | Alessio Marchetti Fabio Redi Francesca Savini Ilaria Trizio | 2017 | Journal of Civil Engineering and Architecture2017，11，10： | 0 |
| 4 | Squamous cell carcinoma of the lung: clinical criteria for treatment strategy显示文摘Aim:Primary lung cancer is the leading cause of human cancer deaths worldwide,and squamous cell carcinoma(SCC)is one of the most frequent histologic subtypes.The aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC patients.Methods:A series of 72 consecutive patients with advanced SCC undergoing chemotherapy at our institution between January 2007 and July 2013 were eligible for our analysis.Results:By univariate analysis,a better overall survival(OS)was related to response to first-line chemotherapy:median OS were 19.7 vs.7.17 months,respectively,for responders and nonresponders patients(P<0.0001).Eastern Cooperative Oncology Group performance status,gender,and surgery were other prognostic factors.No signifi cant relationship between OS and smoking status,age,body mass index,or type of treatment was found.In the third-line setting,a better OS was associated with objective response to second-line treatment(P=0.015).Conclusion:Our results suggest that differences in OS seem strictly associated with clinical response to previous treatments.These data should be considered in the therapeutic strategy and management of patients with SCC of the lung. | Agnese Savini Rossana Berardi Paola Mazzanti Miriam Caramanti Matteo Santoni Mariagrazia De Lisa Francesca Morgese Silvia Rinaldi Mariangela Torniai Ilaria Fiordoliva Azzurra Onofri Stefano Cascinu | 2015 | Journal of Cancer Metastasis and Treatment2015，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员