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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 3 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 4 | 西南极利文斯顿岛汉那角火山岩地质及火山活动显示文摘本文以野外地质资料为基础,并结合岩相学特征,论述了西南极南设得兰群岛利文斯顿岛汉那角(HannahPoint)火山岩地层及岩石的基本特征,初步讨论了该地火山活动过程。该地互层状产出的火山角砾岩和熔岩,为南极半岛火山岩组的一部分。剖面上出露的三个火山岩地层旋回分别是三期火山作用的产物。第一、二旋回岩层产状的变化记录了火山作用过程中的一次活动间歇。第一旋回的英安岩和含有流纹岩质熔岩夹层的凝灰角砾岩仅为第一期火山活动末的产物;第二旋回为三次较强喷发活动的产物,从安山岩质火山碎屑岩为主,经玄武岩-安山岩质熔岩为主,过渡为含有安山岩或流纹岩质熔浆团的火山角砾岩。第三期火山活动可能更强烈,大面积分布的厚层玄武质熔岩无论从产状上还是在岩石学特征方面都有别于其他旋回。火山岩地层总体产状稳定,平缓地倾向北西,表明该区未受到过明显的构造影响,火山活动中心可能有逐步向北西迁移的趋势,与南设得兰群岛岩浆弧演变趋势一致。次火山岩主要为玄武岩质小岩墙,集中在第二旋回底部。第一、二旋回接触界线两侧凝灰角砾岩表现较强的沸石化。这些现象说明该接触面附近为一薄弱带,侵入活动和蚀变均较易发生。 | 郑祥身 Francesc Sabat Josep M Casas Ranimon Pallas | 1994 | 南极研究1994，6，2： | 2 |
| 5 | Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells显示文摘 | FRANCESC M M MATHILDE H RENUKA K P | 2009 | Inc J Biomed Mater Res:B2009，90，2： | 1 |
| 6 | An ac- curate O(n) solution to the PnP problem显示文摘 | VINCENT L FRANCESC M PASCAL F | 2009 | Inter- national Journal of Computer Vision2009，81，2： | 1 |
| 7 | Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria显示文摘 | Cabré Anna Lázaro Iolanda Girona Josefa Manzanares Josep M Marimón Francesc Plana Núria Heras Mercedes Masana Lluís | 2008 | Clinical Chemistry2008，，1： | 1 |
| 8 | A multicentre randomized trial of combined individual and telephone counselling for smoking cessation显示文摘 | Josep M. Ramon Isabel Nerin Araceli Comino Cristina Pinet Francesc Abella José M a Carreras Marta Banque Antoni Baena Sergio Morchon Adriana Jimenez-Muro Adriana Marqueta Assumpcio Vilarasau Raquel Bullon Cristina Masuet-Aumatell | 2013 | Preventive Medicine2013，，： | 1 |
| 9 | The Biopsychosocial Model 25 Years Later: Principles, Practice, and Scientific Inquiry 显示文摘 | Francesc Borrell- Carrio Anthony L Suchman and Ronald M | 2004 | Annals of Family Medicine2004，2，： | 1 |
| 10 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro- exction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 11 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | ALFREDO D FRANCESC V M TERESA G | 2005 | Journal of Chromatography A2005，，97： | 1 |
| 12 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 13 | Induction of gynogenesis in the turbot (Scophthalmus maximus) : Effects of UV irradiation on sperm motility, the Hertwig effect and viability during the flint 6 months of age 显示文摘 | Francesc P Rosa M C Castora G | 2004 | Aquaculture2004，238，： | 1 |
| 14 | Induction of gynogenesis in the turbot (Scophthalmus maximus):Effects of UV irradiation on sperm motility,the Hertwig effect and viability during the first 6 months of age显示文摘 | FRANCESC P ROSA M C CASTORA G | 2004 | Aquaculture2004，238，： | 1 |
| 15 | Economic feasibility study for wastewater treatment:A cost-benefit analysis显示文摘 | María M S Francesc H S Ramón S G | 2010 | Science of the Total Environment2010，408，20： | 1 |
| 16 | Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments显示文摘 | M a Rosa Boleda M a Teresa Galceran Francesc Ventura | 2011 | Environmental Pollution2011，，6： | 1 |
| 17 | Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival显示文摘 | ANTONIO M BEATRIZ B FRANCESC B | 2004 | Am J Pathol2004，164，2： | 1 |
| 18 | The Carbon Footprint and Energy Consumption of Beverage Packaging Selection and Disposal 显示文摘 | JORGELINA P MONTSE M FRANCESC C | 2011 | Journal of Food Engineering2011，103，4： | 1 |
| 19 | Integration of deformable contours and a multiple hypotheses fisher color model for robust tracking in varying illuminant environments 显示文摘 | FRANCESC M N ALBERTO S DIMITRIS S | 2007 | Image and Vision Computing2007，25，： | 1 |
| 20 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro2extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
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