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| 1 | iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel显示文摘The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative endodontics.This study aimed to replicate the characteristics of dental pulp tissue by using cranial neural crest(CNC)-like cells(CNCLCs);these cells were generated by modifying several steps of a previously established method for deriving NC-like cells from induced pluripotent stem cells(iPSCs).CNC is the anterior region of the neural crest in vertebrate embryos,which contains the primordium of dental pulp cells or odontoblasts.The produced CNCLCs showed approximately 2.5-12,000-fold upregulations of major CNC marker genes.Furthermore,the CNCLCs exhibited remarkable odontoblastic differentiation ability,especially when treated with a combination of the fibroblast growth factors(FGFs)FGF4 and FGF9.The FGFs induced odontoblast marker genes by 1.7-5.0-fold,as compared to bone morphogenetic protein 4(BMP4)treatment.In a mouse subcutaneous implant model,the CNCLCs briefly fated with FGF4+FGF9 replicated dental pulp tissue characteristics,such as harboring odontoblast-like cells,a dentin-like layer,and vast neovascularization,induced by the angiogenic self-assembling peptide hydrogel(SAPH),SLan.SLan acts as a versatile biocompatible scaffold in the canal space.This study demonstrated a successful collaboration between regenerative medicine and SAPH technology. | Yoshifumi Kobayashi Julie Nouet Erdenechimeg Baljinnyam Zain Siddiqui Daniel HFine Diego Fraidenraich Vivek A.Kumar Emi Shimizu | 2022 | Bioactive Materials2022，7，8： | 2 |
| 2 | Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells显示文摘 | FRAIDENRAICH D STILLWELL E ROMERO E | 2004 | Science2004，306，5694： | 1 |
| 3 | Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog显示文摘 | Fraidenraich D Iwahori A Rudnicki M | | 0，，： | 1 |
| 4 | Simualtion model of a CPC collector with temperature-dependent heat loss coefficient显示文摘 | Fraidenraich N Dec R Delima F | 1999 | Solar Energy1999，65，2： | 1 |
| 5 | Comparison of the performance of PV water pumping systems driven by fixed, tracking and V-trough generators 显示文摘 | Bione J Vitela O C Fraidenraich N | 2004 | Solar Energy2004，76，10： | 1 |
| 6 | Analytic modeling of a solar power plant with parabolic linear collectors显示文摘 | Milton Matos Rolim Naum Fraidenraich Chigueru Tiba | 2008 | Solar Energy2008，，1： | 1 |
| 7 | Simulation model of a CPC collector with temperature dependent heat loss coefficient显示文摘 | N Fraidenraich CF DE Lima | | 0，，02： | 1 |
| 8 | Analytic solutions for the geometric and optical properties of stationary compound parabolic concentrators with fully illuminated inverted V receiver显示文摘 | Fraidenraich N Chigueru T Branda B B | 2008 | Solar Energy2008，82，2： | 1 |
| 9 | Comparison of the performance of PV water pumping systems driven by fixed, tracking and V-trough generators 显示文摘 | BIONE J VILELA O C FRAIDENRAICH N | 2004 | Solar Energy2004，76，6： | 1 |
| 10 | Analytic modeling of a solar power plant with parabolic linear collectors显示文摘 | ROLIM M M FRAIDENRAICH N TIBA C | 2009 | Solar Energy2009，83，1： | 1 |
| 11 | Simualtion Model of a CPC Collector with Temperature-dependent Heat Loss Coefficient显示文摘 | N Fraidenraich R De C F De Lima C Tiba | 1999 | Solar Energy1999，65，2： | 1 |
| 12 | Nakagami-m phase-envelope joint distribution显示文摘 | Yacoub M D Fraidenraich G Santos F J | 2005 | Electronics Letters2005，41，5： | 1 |
| 13 | Solar energy resource assessment显示文摘 | Tiba C Fraidenraich N | 2002 | Renewable Energy2002，27，3： | 1 |
| 14 | Analytic solutions for the geometric and optical properties of sta- tionary compound parabolic concentrators with fully illumi- nated inverted V receiver 显示文摘 | Fraidenraich N Chigueru T Branda B B | 2008 | Solar Energy2008，82，2： | 1 |
| 15 | A methodology for the design of photovoltaic water supply systems 显示文摘 | Vilela O C Fraidenraich N | 2001 | Progress in Photovoltaics Research and Applications2001，9，1： | 1 |
| 16 | Performance of solar systems with non-linear behavior calculated by the utilizability method: application to PV solar pumps显示文摘 | Fraidenraich N Vilela O C | 2000 | Solar Energy2000，69，2： | 1 |
| 17 | Solar energy resource assessment显示文摘 | Tiba C Fraidenraich N Grossi Galleqos H | 2002 | Renewable Energy2002，27，3： | 1 |
| 18 | Analytic modelingof a solar power plant with parabolic linear collectors 显示文摘 | Rolim M M Fraidenraich N Tiba C | 2009 | Solar Energy2009，83，1： | 1 |
| 19 | Solar Energy Resource Assessment显示文摘 | Fraidenraich N Grossi Galleqos H | 2002 | Renewable Energy2002，27，3： | 1 |
| 20 | Analytic Modeling of a Solar Power Plant with Parabolic Linear Collectors 显示文摘 | Rolim M M Fraidenraich N Tiba C | 2009 | Solar Energy2009，83，1： | 1 |
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