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| 1 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 2 | The evolution of the atmosphere in the Archaean and early Proterozoic显示文摘Key steps in atmospheric evolution occurred in the Archaean.The Hadean atmosphere was created by the inorganic processes of volatile accretion from space and degassing from the interior,and then modified by chemical and photochemical processes.The air was probably initially anoxic,though there may have been a supply of oxidation power as a consequence of hydrodynamic escape to space of hydrogen from water.Early subduction may have removed CO2 and the Hadean planet may have been icy.In the Archaean,as anoxygenic and then oxygenic photosynthesis evolved,biological activity remade the atmosphere.Sedimentological evidence implies there were liquid oceans despite the faint young Sun.These oceans may have been sustained by the greenhouse warming effect of biologically-made methane.Oxygenesis in the late Archaean would have released free O2 into the water.This would have created oxic surface waters,challenging the methane greenhouse.After the Great Oxidation Event around 2.3 to 2.4 billion years ago,the atmosphere itself became oxic,perhaps triggering a glacial crisis by cutting methane-caused greenhouse warming.By the early Proterozoic,all the key biochemical processes that maintain the modern atmosphere were probably present in the microbial community. | NISBET Euan FOWLER C Mary R | 2011 | Chinese Science Bulletin2011，56，1： | 2 |
| 3 | Effect of interleukin-8 (IL-8),anti-IL-8,and IL-12 on endometrial cell survival in combined endometrial gland and stromal cell cultures derived from women with and without endometriosis显示文摘 | Gazvani R Smith L Fowler PA | 2002 | Fertil Steril2002，77，1： | 1 |
| 4 | School functioning of US children with asthma显示文摘 | FOWLER M G DAVENPORT M G GARG R | 1992 | Pediatrics1992，90，6： | 1 |
| 5 | An evaluation ofthe national safety council,s defensive driving course invarious states 显示文摘 | Planek T W Schupack S A Fowler R C | 1974 | Accident Analysis & Prevention1974，6，34： | 1 |
| 6 | A Threshold Model of Content Knowledge Transfer for Socioscientific Argumentation 显示文摘 | SADLER T D FOWLER S R | 2006 | Science Education2006，90，： | 1 |
| 7 | HLA-A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection显示文摘 | Nayersina R Fowler P | 1993 | J lmmunol1993，150，10： | 1 |
| 8 | Paliperidone extended release tablets for the acute and maintenance treatment of schizophrenia 显示文摘 | Fowler J A Bettinger T L Argo T R | 2008 | ClinTher2008，30，2： | 1 |
| 9 | Interplanetary flyby mission optimization using a hybrid global/local search method显示文摘 | Crain T P Bishop R H Fowler W T | 2000 | Journal of Spacecraft and Rockets2000，37，4： | 1 |
| 10 | Improved oxygen reduction activity on Pt3Ni (111) via increased surface site availability显示文摘 | STAMENKOVIC V R FOWLER B MUN B S | 2007 | Science2007，315，5811： | 1 |
| 11 | Improved OxygenReduction Activity on Pt3Ni(lll) via Increased Surface SiteAvailability 显示文摘 | Stamenkovic V R Fowler B Mun B S | 2007 | Science2007，315，5811： | 1 |
| 12 | Cambrian-Ordovician shales in the Humber Zone: Thermal maturation and source rock potential显示文摘 | Bertrand R Lavoie D Fowler M | 2003 | Bulletin of Canadian Petroleum Geology2003，51，3： | 1 |
| 13 | Electron emission in intense electric fields显示文摘 | Fowler R H Nordheim L | | 0，，： | 1 |
| 14 | Fluid resuscitation of the patient with major trauma显示文摘 | Fowler R Pepe PE | 2002 | Curr Opin Anaesthesiol2002，15，2： | 1 |
| 15 | Improved oxygen reduction activity on Pt3Ni (111) via increased surface site availability 显示文摘 | Stamenkovie V R Fowler B Mun B S | 2007 | Science2007，315，： | 1 |
| 16 | Deposition of atmospheric pollutants to the LOIS area显示文摘 | Smith R I Cape J N Binnie J Murray T D Young M and Fowler D | 1997 | Science of the Total Environment1997，，： | 1 |
| 17 | Multidetector computed tomography for acute pulmonary embolism显示文摘 | Stein P D Fowler S E Goodman L R | | 0，，22： | 1 |
| 18 | An evaluation of sequence tagged microsatellite site markers for genetic analysis within Citrus and relatedspecies显示文摘 | Kijas J M H Fowler J C S Thomas M R | 1995 | Genome1995，38，： | 1 |
| 19 | Management of lower urinary tract symptoms in men with progressive neurological disease 显示文摘 | Woderich R Fowler CJ | 2006 | Curr Opin Urol2006，16，1： | 1 |
| 20 | Allogenic lymphocytes induce tumor regression of advanced metastatic breast cancer显示文摘 | BISHOP M R FOWLER D H MARCHIGIANI D | 2004 | J Clin Oncol2004，22，19： | 1 |
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