|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Effects of protein content and composition on white noodle making quality: color 显示文摘 | Wang C Kovacs M I P Fowler D B | 2004 | Cereal Chemistry2004，81，： | 1 |
| 3 | Mice with a null mutation of the TGF-alpha gene have abnormal skin architecture,wavy hair,and curly whiskers and often develop corneal inflammation显示文摘 | MANN G B FOWLER K J GABRIEL A | 1993 | Cell1993，73，2： | 1 |
| 4 | Electronic properties of two-dimensional systems 显示文摘 | Ando T Fowler A B Stern F | 1982 | Rev Mod Phys1982，54，2： | 1 |
| 5 | US for detecting renal calculi with nonenhanced CT as a reference standard 显示文摘 | Fowler K A B Locken J A Duchesne J H | 2002 | Radiology2002，222，1： | 1 |
| 6 | Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade 显示文摘 | Mackman N Morrissey JH Fowler B | 1989 | Biochemistry1989，28，4： | 1 |
| 7 | The Haddon matrix:Applying an epidemiologic research tool as a framework for death inveatigation显示文摘 | Conroy Carol M P H Fowler John B S | 2000 | The America Journal of Forensic Medicine and Pathalogy2000，21，04： | 1 |
| 8 | Improved oxygen reduction activity on Pt3Ni (111) via increased surface site availability显示文摘 | STAMENKOVIC V R FOWLER B MUN B S | 2007 | Science2007，315，5811： | 1 |
| 9 | Nanoscale Materials with Mesostructured Interiors显示文摘 | Fowler C E Khushalani D Lebean B | 2001 | Adv Mater2001，13，9： | 1 |
| 10 | A system for freezing biological materials显示文摘 | Gusta L V Boyachek M Fowler D B | 1978 | Hort Science1978，13，： | 1 |
| 11 | Accumulation of an acidic dehydrin in the vicinity of the plasma membrane during cold acclimation of wheat显示文摘 | Danyluk J Perron A Houde M Limin A Fowler B Benhamou N Sarhan F | 1998 | Plant Cell1998，10，4： | 1 |
| 12 | Developmental regula tion of low-temperature tolerance in winter wheat显示文摘 | Mahfoozi S Limin A E Fowler D B | 2001 | Annals of Botany2001，87，： | 1 |
| 13 | Bar-code technology for medication administration: medication errors and nurse sa- tisfaction显示文摘 | Fowler S B Sohler P Zarillo D F | 2009 | Medsurg Nuts2009，18，2： | 1 |
| 14 | Improved OxygenReduction Activity on Pt3Ni(lll) via Increased Surface SiteAvailability 显示文摘 | Stamenkovic V R Fowler B Mun B S | 2007 | Science2007，315，5811： | 1 |
| 15 | Nanoscale materials with mesostructured interiors显示文摘 | Fowler C E Khushalani D Lebeau B | 2001 | Adv Mater (Weinheim Ger)2001，13，： | 1 |
| 16 | The influence of thermochemical sulphate reduction on hydrocarbon tomposition in Nisku reservoirs,Brazeau river area,Alberta,Canada显示文摘 | MANZANO B K FOWLER M G MACHEL H G | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 17 | Improved oxygen reduction activity on Pt3Ni (111) via increased surface site availability 显示文摘 | Stamenkovie V R Fowler B Mun B S | 2007 | Science2007，315，： | 1 |
| 18 | Interactions among factors regulating phenological development and acclimation rate determine lowtemperature tolerance in wheat显示文摘 | Fowler D B Limin A E | 2004 | Annals of Botany2004，94，5： | 1 |
| 19 | A third generation water bath based black- body source显示文摘 | FOWLER J B | 1995 | Journal of Research-National Institute of Standards and Technology1995，100，： | 1 |
| 20 | Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species 显示文摘 | Diebold B A Fowler B Lu J | 2004 | J Biol Chem2004，279，28： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员