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| 1 | Simultaneous determination of amino acids in different teas using supercritical fluid chromatography coupled with single quadrupole mass spectrometry显示文摘Tea is a widely consumed beverage and has many important physiological properties and potential health benefits. In this study, a novel method based on supercritical fluid chromatography coupled with mass spectrometry (SFC-MS) was developed to simultaneously determine 11 amino acids in different types of tea (green teas, Oolong tea, black tea and Pu-erh tea). The separation conditions for the analysis of the selected amino acids including the column type, temperature and backpressure as well as the type of additive, were carefully optimized. The best separation of the 11 amino acids was obtained by adding water (5%, v/v) and trifluoroacetic acid (0.4%, v/v) to the organic modifier (methanol). Finally, the developed SFC-MS method was fully validated and successfully applied to the determination of these amino acids in six different tea samples. Good linearity (r ≥ 0.993), precision (RSDs≤ 2.99%), accuracy (91.95%-107.09%) as well as good sample stability were observed. The limits of detection ranged from 1.42 to 14.69 ng/mL, while the limits of quantification were between 4.53 and 47.0 ng/mL. The results indicate that the contents of the 11 amino acids in the six different tea samples are greatly influenced by the degree of fermentation. The proposed SFC-MS method shows a great potential for further investigation of tea varieties. | Yang Huang Tiejie Wang Marianne Fillet Jacques Crommen Zhengjin Jiang | 2019 | Journal of Pharmaceutical Analysis2019，9，4： | 7 |
| 2 | Degradation characteristics of hydrolysis-sensitive poly显示文摘 | Crommen J H L Schacht E H Mense E H G Biodegradable polymers: Ⅱ | 1992 | Biomaterials1992，13，： | 1 |
| 3 | Determination of six water-soluble vitamins in a pharmaceutical formulation by capillary electrophoresis显示文摘 | L. Fotsing M. Fillet I. Bechet Ph. Hubert J. Crommen | 1997 | Journal of Pharmaceutical and Biomedical Analysis1997，，8： | 1 |
| 4 | Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis显示文摘 | Fillet M Chankvetadze B Crommen J | 1999 | Electrophoresis1999，20，13： | 1 |
| 5 | Enantiomeric separation of N-FMOC amino acids by non-aqueous Capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors显示文摘 | Pitte V Lindner W Crommen J | 2002 | Journal of Chromatography A2002，948，： | 1 |
| 6 | Impurity fingerprints for the identification of counterfeit medicines—A feasibility study显示文摘 | Pierre-Yves Sacré Eric Deconinck Michal Daszykowski Patricia Courselle Roy Vancauwenberghe Patrice Chiap Jacques Crommen Jacques O. De Beer | 2011 | Analytica Chimica Acta2011，，2： | 1 |
| 7 | Influence of methanol on the enantioresolution of antihistamines with carboxymethyl-beta-eycledextrin in capillary显示文摘 | VAN E A DETAEVEMIER M R CROMMEN J | 2004 | Electrophor2004，25，16： | 1 |
| 8 | 显示文摘 | FILLETM FOTSING L CROMMEN J | 1998 | J Chromatogr A1998，817，12： | 1 |
| 9 | Capillary electrophoresis- mass spectrometry, an attractive tool for drug bioanalysis and bi- omarker discovery显示文摘 | Servais A C Crommen J Fillet M | 2006 | Electrophoresis2006，27，： | 1 |
| 10 | Enantiomeric separations of drugs using mixtures of charged and neutral cyclodextrins显示文摘 | Fillet M Hubert P Crommen J | 2000 | J Chrom- atogr A2000，875，12： | 1 |
| 11 | Capillary electrophoresis-massspectrometry,an attractive tool for drug bioanalysis and biomarkerdiscovery显示文摘 | Servais AC Crommen J Fillet M | 2006 | Electrophoresis2006，27，13： | 1 |
| 12 | Influence of methanol on the enantioresolution of antihistamines with carboxymethyl-beta-cyclodextrin in capillary electrophoresis 显示文摘 | VAN EECKHAUT A DETAEVERNIER M R CROMMEN J | 2004 | Electrophoresis2004，25，16： | 1 |
| 13 | Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinine derivatives serving as chiral selectors显示文摘 | PIETTE V LINDNER W CROMMEN J | 2002 | J Chromatogr A2002，948，12： | 1 |
| 14 | Enantiosepara- ton of anionic analytes by non-aqueous capillary e- lectrophoresis using quinine and quinidine deriva- tives as chiral counter-ions显示文摘 | Piette V Lindner W Crommen J | 2000 | J Chromatogr A2000，894，12： | 1 |
| 15 | Influence of methanol on the enantioresolution of antihislamines with carboxymethyl-β-cyclodextrin in capillary electrophoresis 显示文摘 | VAN E A DETAEVEMIER M R CROMMEN J | 2004 | Electrophoresis2004，25，16： | 1 |
| 16 | Influence of methanol on the enantioresolutian of antihistamines with carboxymethyl-beta-cyclodextrin in capillary electrophoresis 显示文摘 | Van Eeckhaut A Detaevernier M R Crommen J | 2004 | Electrophoresis2004，25，16： | 1 |
| 17 | Degradable polyphosphazenes for bio - medical applications 显示文摘 | Crommen J Vandorpe J Sehacht E | 1993 | J Control Release1993，24，： | 1 |
| 18 | Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors显示文摘 | Piette V Lindner W Crommen J | 2002 | J Chromatogr A2002，948，12： | 1 |
| 19 | Influence of methanol on the enantioresolutian of antihistamines with carboxymethyl-beta-eycledextrin in capillary 显示文摘 | VAN Eeekhaut A Detaevernier M R Crommen J | 2004 | Electrophor2004，25，16： | 1 |
| 20 | Enantioseparaton of anionic analytes by non-aqueous capillary electrophoresis using quinine and quinidine derivatives as chiral counter-ions显示文摘 | Piette V Lindner W Crommen J | 2000 | J Chromatogr A2000，894，12： | 1 |
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