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| 1 | Optimal control homotopy perturbation method for cancer model显示文摘In this paper, we introduced the optimal control homotopy perturbation method (OCHPM) by using the homotopy perturbation method (HPM). Every one, by using of the proposed method, can obtain numerical solutions of mathematical modeling for cancer-immunotherapy. In this paper, in order to prove the preciseness and efficiency of the OCHPM method, we compared the obtained numerical solutions with HPM. The results obtained showed that the OCHPM method is powerful to generate the numerical solutions for some therapeutic models. | Malihe Najafi Hadi Basirzadeh | 2019 | International Journal of Biomathematics2019，12，3： | 1 |
| 2 | Synthesis,Crystal Structure and Biological Activity of 2-[(Pyridin-2-yl)methylthio]-1H-benzimidazole Derivatives显示文摘In order to discover the novel anti-tumor agents, a series of 2-[(pyridin-2-yl)methylthio]-1 H-benzimidazole derivatives were designed and synthesized, and the structures were characterized by IR, MS, and proton NMR. 2-[(3,4-Dimethoxypyridin-2-yl)methylthio]-1 Hbenzimidazole was investigated with X-ray crystallography, and the molecule is in orthorhombic system, space group P212121, with a = 9.1828(16), b = 11.625(2), c = 13.463(2) ?, Z = 4, R = 0.0231 and wR = 0.0596. The antitumor activities of target compounds were evaluated against human liver cancer cell line HepG2, and human liver normal cell line HL7702 using MTT assay. The target compounds have demonstrated weak or moderate anti-tumor activity against HepG2, while all the target compounds exhibit no cytotoxic effects on HL7702. | 高迪 陈固洲 曹胜 杜月 金辄 刘晓平 欧阳贵平 胡春 | 2017 | Chinese Journal of Structural Chemistry2017，36，12： | 0 |
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