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| 1 | Targeted therapy in first line treatment of RAS wild type colorectal cancer显示文摘The debate on the optimal drug combination for treating chemotherapy-nave patients with metastatic colorectal cancer has recently become particularly heated.The present editorial will review recent data on this topic.The FIRE-3 and PEAK trials have shown a 7.5 to 12 mo survival advantage with the use anti-epidermal growth factor receptor(anti-EGFR)antibodies.The CALGB 80405 has shown no difference between anti-EGFR and anti-vascular endothelial growth factor agents.All three trials have consistently shown a significant increase in objective response rate.These data suggest that there is a subset of metastatic colorectal cancer patients,rigorously selected by molecular profiling,who particularly benefit from an anti-EGFR-based regimen in the first-line setting. | Vincenzo Formica Mario Roselli | 2015 | World Journal of Gastroenterology2015，21，10： | 6 |
| 2 | Immune reaction and colorectal cancer:Friends or foes?显示文摘The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors.Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship.Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified,still no approved therapies based on host immunity intensification have so far been introduced in clinical practice.Moreover,a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this approach.The aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease. | Vincenzo Formica Vittore Cereda Antonella Nardecchia Manfredi Tesauro Mario Roselli | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 3 | Approximating Geographical Queries显示文摘This article proposes a graph-theoretic methodology for query approximation in Geographic Information Systems, enabling the relaxation of three kinds of query constraints: topological, semantic and structural. An approximate query is associated with a value corresponding to the degree of similarity with the original query. Such a value is computed for topological constraints on the basis of the topological distance between configurations, for semantic constraints using the information content approach, and for structural constraints revisiting the maximum weighted matching problem in bipartite graphs. Finally, the high correlation of our proposal with human judgment is demonstrated by an experiment. | Arianna D’Ulizia Fernando Ferri Anna Formica Patrizia Grifoni | 2009 | Journal of Computer Science & Technology2009，24，6： | 3 |
| 4 | Peripheral CD45RO, PD-1, and TLR4 expression in metastatic colorectal cancer patients treated with bevacizumab, fluorouracil, and irinotecan (FOLFIRI-B)显示文摘 | Vincenzo Formica Vittore Cereda Maria-Giovana Bari Italia Grenga Manfredi Tesauro Palmirotta Raffaele Patrizia Ferroni Fiorella Guadagni Mario Roselli | 2013 | Medical Oncology2013，，4： | 2 |
| 5 | Segmentation of travelers based on environmental attitudes 显示文摘 | Formica S Uysal M ( 2002 ) | 2002 | Journal of Hospitality and Leisure Marketing2002，9，34： | 1 |
| 6 | Review of the biology of quercetin and related bioflavonoids显示文摘 | Formica JV Regelson W | 1995 | Food Chem Toxicol1995，33，12： | 1 |
| 7 | Extracorporeal membrane oxy- genation to support adult patients with cardiac failure:predictive factors of 30-day mortality 显示文摘 | Formica F Avalli L Colagrande L | 2010 | Interact Cardiovasc Thorac Surg2010，10，5： | 1 |
| 8 | Drug-induced increase of car-cinoembryonic antigen expression in cancer cells 显示文摘 | Aguino A Formica V Preto SP | 2004 | PharmacolRes2004，49，5： | 1 |
| 9 | Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis显示文摘 | Yarlagadda SG Coca SG Formica RN Jr | 2009 | Nephrol Dial Transplant2009，24，3： | 1 |
| 10 | The revitalization of Italy as a tourist destination显示文摘 | Formica S Uysal M | 1996 | Tourism Management1996，17，5： | 1 |
| 11 | Randomised con2 trolled study of effect of parathyroid hormone on vertebral2 bone mass and fracture incidence among postmenopausalwomen on estrogen with osteoporosis[J显示文摘 | Lindsay R Nieves J Formica C | | 0，，： | 1 |
| 12 | Dialysis adequacy and Kt/V显示文摘 | Formica M Bosticardo G | 2011 | hal Nefrol2011，28，2： | 1 |
| 13 | The Development of Festivals and Special Events Studies显示文摘 | Formica S | 1998 | Festival Management & Event Tourism1998，5，3： | 1 |
| 14 | Efficient fluorescent sensors based on 2,5-diphenyloxadiazole: a case of specific response to ZnⅡ) at physiological pH显示文摘 | Ambrosi G Formica M Fusi V | 2010 | Inorg Chem2010，49，： | 1 |
| 15 | Therapeutic doses of iodine-131 reveal Undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels显示文摘 | PACINI F LIPPI F FORMICA N | 1987 | J Nucl Ailed1987，28，12： | 1 |
| 16 | Humoral immunity to human metapneumovirus infection in adults显示文摘 | Falsey AR Hennessey PA Formica MA | 2010 | Vaccine2010，28，6： | 1 |
| 17 | The revitalization of Italy as a tourist desti- nation 显示文摘 | Formica M Uysal | 1996 | Tourism Management1996，17，5： | 1 |
| 18 | Open-door laminoplasty for cervical stenotic myelopathy :surgical technique and neuro- physiological monitoring显示文摘 | Roselli R Pompucci A Formica F | 2000 | J Neurosurg2000，92，1： | 1 |
| 19 | Myocardial revas- cularization with miniaturized extracorporeal circulation ver- sus off pump : Evaluation of systemic and myocardial inflam- matory response in a prospective randomized study 显示文摘 | Formica F Broccolo F Martino A | 2009 | J Thorac Cardiovasc Surg2009，137，5： | 1 |
| 20 | Respiratory syncytial virus infection in elderly and high?risk adults显示文摘 | Falsey AR Hennessey PA Formica M A | 2005 | N EnglJ Med2005，352，17： | 1 |
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