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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Childhood Functional Gastrointestinal Disorders: Child/Adolescent显示文摘 | Andrée Rasquin Carlo Di Lorenzo David Forbes Ernesto Guiraldes Jeffrey S. Hyams Annamaria Staiano Lynn S. Walker | 2006 | Gastroenterology2006，，5： | 5 |
| 3 | 利用腰围身高比预测有雄激素缺乏症的老年男性体内血清睾酮水平显示文摘老年男性血清睾酮的下降可能部分是由肥胖引起的,但是,还不能确定哪些肥胖相关的参数与睾酮水平最密切相关。我们研究过伴有雄激素缺乏症但健康状况良好的老年男性的年龄、肥胖和睾酮水平的关系。本研究中,我们从社区中募集了54岁以上无痛症或其他严重疾病的非吸烟男性做横向研究分析,测定身高,体重和腰围,并计算体质指数(BMI)和腰围身高比(WHt)。收集两个早上的血液样本,测量总睾酮,性激素结合球蛋白和促黄体激素。计算游离睾酮(cFT)。并对上述指标与肥胖参数之间的关系进行多元线性凹归分析。207名54-86岁之间的男性参与了此次研究。单因素分析结果表明腰围身高比与睾酮和游离睾酮的相关性明显高于体重和腰吲或体质指数。另外,对总睾酮和游离睾酮来说,体重和腰围以及身高都有重要意义(所有的P均小于0.05),身高值中加入体重和腰围值后,导致体重和腰用以及身高的回归系数都增加了,其中腰围呈负相关,身高呈正相关。总之,腰围身高比是预测健康但有雄激素缺乏症的老年男性的睾酮和游离睾酮最好的体质指标。 | Carolyn A Allan Roger E Peverill Boyd JG Strauss Elise A Forbes Robert I McLachlan | 2011 | Asian Journal of Andrology2011，13，3： | 3 |
| 4 | The specific adsorption of divalent Cd, Co, Cu, Pb and Zn on goethite 显示文摘 | FORBES E A POSNER A M QUIRK J P | 1976 | J Soil Sci1976，27，： | 1 |
| 5 | Mitochondrial DNA variation in Indo-Pacific populations of the giant tiger prawn, Penaeus monodon 显示文摘 | Benzie J A H Ballment E Forbes A T | 2002 | Molecular Ecology2002，11，12： | 1 |
| 6 | Relative role of pore water versus ingested sediment in bioavailability of organic contaminants in marine sediments显示文摘 | Forbes T L Forbes V E Giessing A | | 0，，12： | 1 |
| 7 | The Wilson disease gene: spectrum of mutations and their consequences 显示文摘 | Thomas G R Forbes J R Roberts E A | 1995 | Nat Genet1995，9，2： | 1 |
| 8 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 9 | K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures 显示文摘 | Glicksman M A Forbes M E Pranmer J E | 1995 | J Neurochem1995，64，： | 1 |
| 10 | Renal microvascu- lar injury in diabetes:RAGE and redox signaling 显示文摘 | COUGHLAN M T COOPER M E FORBES J M | 2007 | Antioxid Red- ox Signal2007，9，3： | 1 |
| 11 | The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website显示文摘 | Bamford S Dawson E Forbes S | | 0，，： | 1 |
| 12 | Alliance management: a view from the past and a look to the future显示文摘 | Spckman R E Forbes T M Isabella L A Macavoy T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 13 | Isentropic compression loading of octahydro-1,3,5,7-tetranitro-1, 3,5,7-tetrazocine (HMX) and the pressure-induced phase transition at 27 GPa 显示文摘 | Hare D E Forbes J W Reisman D B | 2004 | Appl Phys Lett2004，85，6： | 1 |
| 14 | High precision metrology of domes and aspheric optics显示文摘 | Paul E Murphy Jon Fleig Greg Forbes | 2005 | Proceedings of SPIE2005，5786，： | 1 |
| 15 | The specific adsorption of divalent Cd,Co,Cu,Pb and Zn goethite显示文摘 | Forbes E A Posner A M Quirk J P | 1976 | Journal of Soil Science1976，27，： | 1 |
| 16 | Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism显示文摘 | Forbes RA Steenbergen C Murphy E | 2001 | Circ Res2001，88，8： | 1 |
| 17 | Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets:significance for VEGF measurements and cancer biology显示文摘 | BANKS R E FORBES M A KINSEY S E | 1998 | British J Cancer1998，77，6： | 1 |
| 18 | CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression 显示文摘 | Whelan J T Forbes S L Bertrand F E | 2007 | Cell Cycle2007，6，1： | 1 |
| 19 | Redution of the accumulation of advanced glycation and by ACE inhibition in experimental diabetic nephropathy 显示文摘 | Forbes J M Cooper M E | 2002 | Diabetes2002，51，11： | 1 |
| 20 | Creating strategic alliances which endure 显示文摘 | SPEKMEN R E A I LYNN T C MACAVOY I FORBES | 1996 | Long Range Planning1996，29，3： | 1 |
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