维普中文期刊产品整合服务
4篇 您的检索式:作者名="Folkert J van"
    题名 作者 年代 出处 被引量
1Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels.Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers 2006World Journal of Gastroenterology2006,12,40:4
2Hypertrophic cardiomyopathy in a large community-based population: clinical outcome and identification of risk factors for sudden cardiac death and clinical deterioration显示文摘Marcel J.M Kofflard Folkert J Ten Cate Chris van der Lee Ron T van Domburg 2003Journal of the American College of Cardiology2003,,6:1
3显示文摘Kraneveld AD Folkerts G Van Dosterhout A J 1997Intern J lmmunophoramacol1997,19,910:1
4SurePath、ThinPrep和传统细胞学3种方法常规筛查阴性后的宫颈癌发病率的研究:基于人群研究显示文摘摘要 目的比较3种不同筛查方法即传统细胞学、液基细胞学(Sure Path和Thin Prep)检测阴性后72个月内宫颈癌的累积发病率。设计以人群为基础的回顾性队列研究。背景从2000年1月-2013年3月在荷兰全国范围内网络登记的有组织病理学或细胞病理学情况的宫颈癌数据。Kirsten Rozemeijer Steffie K Naber Corine Penning Lucy H Overbeek Caspar W N Looman Inge M C M de Kok Suzette M Matthijsse Matejka Rebolj Folkert J van Kemenade Marjolein van Ballegooijen 张雪芳 王淑珍 2018英国医学杂志中文版2018,21,3:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费